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Dr. Raffaele Pilla, Pharm.D., Ph.D.

Doctor Europaeus

Present

Fatebenefratelli Pharmacy, Benevento

Benevento

Italy

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Raffaele Pilla, Pharm.D., Ph.D., Doctor Europaeus, received his Master’s degree in Pharmacy at G. d’Annunzio University in Chieti-Pescara, Italy in 2005, where he also served internships at the Cell Physiology Laboratory and Molecular Biology Laboratory. Prior to his degree, he was an Erasmus Student at Faculté de Pharmacie de Reims in Reims, France. He received his Doctor Europaeus in 2010 from Pitié-Salpétrière Institute in Paris, France. Also in 2010, he received his Ph.D. in Biochemistry, Physiology, and Pathology of Muscle at G. d’Annunzio University in Chieti-Pescara, Italy. He was hired as a Postdoctoral Scholar in the Department of Pharmacology and Physiology at the University of South Florida in Tampa, on two research grants respectively funded by the Office of Naval Research (US Navy) and Divers’ Alert Network. He has written and lectured widely on his experiences. Dr. Pilla has been involved in ongoing research at the University of South Florida with the use of ketone esters. The initial work, funded by the Office of Naval Research, focused on using ketone esters to prevent CNS oxygen toxicity. Dr. Pilla is working to coordinate efforts in the United States and Italy to expand the ketone ester research to other conditions such as epilepsy and cancer and its use as an alternative metabolic fuel. Dr. Pilla has also served extensively in various international medical missions, orphan and homeless programs, emergency medicine rescue and training, and animal rescue and fostering. He is fluent in Italian, English, French, and Spanish. He has a special interest in journalism and photography, and he enjoys sailing, SCUBA diving, ultralight airplane piloting, soccer, volleyball, jogging, and motorcycles.

  • Neurology
  • Epilepsy
  • Brain Cancers
  • Metastatic Cancers
  • Ketone Esters Adopted in the Metabolic Treatment of Epilepsy and Cancer
  • Ketogenic Diet Administered in Patients Affected by Epilepsy and Cancer
  • Alzheimer’s Disease
  • Glut 1 Deficiency Syndrome
  • Traumatic Brain Injury
  • Hyperbaric/Hypobaric Physiology
  • Hyperbaric/Hypobaric Chamber
  • Oteyola A.O., Pilla R., Ola-Oladimeji F.A., Fagbuaro O. Nanoemulsion Applications: Application of Nanoemulsion in Prostate Cancer Treatment. Book chapter for: Handbook of Research on Natural Products Application and Combination Therapy in Colorectal CancerTreatment. DOI: 10.4018/978-1-7998-9258-8.ch004.
  • Pilla R. Clinical Applications of Ketogenic Diet-Induced Ketosis in Neurodegenerative and Metabolism-Related Pathologies. MDPI Proceedings 2020, 61, 29; doi:10.3390/IECN2020-06982.
  • Pilla R. Therapeutic Ketosis and the Broad Field of Applications for the Ketogenic Diet: Ketone Ester Applications and Clinical Updates. J Nutr Food Sci 2019, Vol 9 - DOI: 10.4172/2155-9600-C6-104.
  • De Lipsis L., Rubino A., D’Argenio M., Santucci F. and Pilla R. Electroencephalogram and Somatosensory Evoked Potentials in Resuscitation. Indications, clinical pictures and treatment principles. Book chapter for: Epilepsy in Intensive Care Unit. ISBN: 978-88-3359-071-4 – 1st edition January 2019.
  • D’Angelo G., Pilla R., Tascini C. and Rampone S. A Proposal for Distinguishing Between Bacterial and Viral Meningitis Using Genetic Programming and Decision Trees. Soft Computing: DOI 10.1007/s00500-018-03729-y; ISSN 1432-7643.
  • Pilla R. The Ketogenic Diet and its Clinical Applications in Type I and II Diabetes. Eurasian Journal of Food Science and Technology 2 (2018): 85-92.
  • Pilla R. Therapeutic Ketosis and the Broad Field of Applications for the Ketogenic Diet: Ketone Ester Applications and Clinical Updates. FONGAR – International Conference on Food, Nutrition and Dietetics, Gastronomy Research, November 2018, Haydarpasha Palace Hotel, Alanya, Turkey FONGAR Proceeding E-Book.
  • Pilla R. The Ketogenic Diet and its Clinical Applications in Type I and II Diabetes. FONGAR – International Conference on Food, Nutrition and Dietetics, Gastronomy Research, November 2018, Haydarpasha Palace Hotel, Alanya, Turkey FONGAR Proceeding E-Book.
  • Pilla R. The Ketogenic Diet and its Clinical Applications in Type I and II Diabetes Int J Diabetes Clin Res 2018, 5:092.
  • Pilla R. Clinical applications of ketogenic diet-induced ketosis in neurodegenerative and metabolism- related pathologies Nutri Food Sci J. 2018; 2(1):115.
  • Pilla R. Ketosis as a treatment for multiple metabolic and neurodegenerative pathologies. J. Transl. Sci. Volume 4(1): 1-6. doi: 10.15761/JTS.1000201. ISSN: 2059-268X.
  • D’Angelo G., Pilla R., Dean J.B. and Rampone S. Toward a soft computing-based correlation between oxygen toxicity seizures and hyperoxic hyperpnea Soft Computing: DOI 10.1007/s00500-017-2512-z.
  • Pilla R. The ketogenic diet approach as metabolic treatment for a variety of diseases. J. Epilepsy: 2:2 http://dx.doi.org/10.4172/2472-0895.1000e010.
  • Viggiano A., Pilla R., Arnold P., Monda M., D’Agostino D.P., Zeppa P. and Coppola G. Different calorie restriction treatments have similar anti-seizure efficacy. Seizure: Feb; 35:45-9.
  • Viggiano A., Pilla R., Arnold P., Monda M., D’Agostino D.P. and Coppola G. Anticonvulsant properties of an oral ketone ester in a pentylenetetrazole-model of seizure. Brain Res.: 1618, 50-54.
  • Perrotta M., Buonomo B., Cascino G., Infante R., Pilla R., Viggiano A. and Coppola G. Oral synthetic ketone ester can affect normal body weight gain in young rats. Translational Medicine @ Unisa: 1, 49 – ISSN 2239-9747.
  • Pilla R., Held H.E., Ciarlone G., Landon C.S. and Dean J.B. Female rats are more susceptible to central nervous system oxygen toxicity than male rats. Physiol. Rep.: Apr 9;2(4):e00282. doi: 10.14814/phy2.282.
  • Ari C., Pilla R., D’Agostino D.P. Nutritional/metabolic therapies in animal models of ALS, Alzheimer's disease and seizures. Book Chapter for: Bioactive Nutriceuticals and Dietary Supplements in Neurological and Brain Disease: Prevention and Therapy.
  • Pilla R., Landon C.S. and Dean J.B. A potential early physiological marker for CNS oxygen toxicity: hyperoxic hyperpnea precedes. seizure in unanesthetized rats breathing hyperbaric oxygen. J. Appl. Physiol.: 114(8), 1009-20.
  • D’Agostino D.P., Pilla R., Held H.E., Landon C.S., Puchowicz M., Brunengraber H., Ari C., Arnold P. and Dean J.B. Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats. Am J Physiol Regul Integr Comp Physiol.. 304(10):R829-36.
  • Pilla R., Held. H.E., Landon C.S. and Dean J.B. High doses of pseudoephedrine hydrochloride accelerate onset of CNS oxygen toxicity seizures in unanesthetized rats. Neuroscience: Aug 29; 246:391-6. doi: 10.1016/j.neuroscience.2013.04.035.
  • Pilla R. PP protein found in skeletal muscle of several specimens: A graduate school story. Postdoc Journal, Journal of Postdoctoral Affairs 2(2).
  • Guarnieri S., Morabito C., Paolini C., Boncompagni S., Pilla R., Fanò-Illic G. and Mariggiò M.A. Growth Associated Protein 43 is expressed in skeletal muscle fibers and is localized in proximity of mitochondria and calcium release units. PLoS One 8(1):e53267. doi: 10.1371/journal.pone.0053267.
  • Pilla R. A neuron-specific protein found in skeletal muscle: new frontiers for GAP-43. Dissertation.com: http://www.dissertation.com ISBN-10: 1-61233-785-6; ISBN-13: 978-1-61233-785-2.
  • Morabito C., Bosco G., Pilla R., Corona C., Mancinelli R., Zhongjin Y., Camporesi E.M., Fanò G. and Mariggiò M.A. Effect of pre-breathing oxygen at different depth on oxidative status and calcium concentration in lymphocytes of scuba divers. ActaPhysiologica 202(1), 69-78.
  • Mariggiò M.A., Falone S., Morabito C., Guarnieri S., Mirabilio A., Pilla R., Bucciarelli T., Verratti V. and Amicarelli F. Peripheral blood lymphocytes: a model for monitoring physiological adaptation to high altitude. High Alt. Med. Biol. 11(4), 333-342.
  • Galluccio A.G., Pezza M., Pilla R., M. Pilla Photo-induced Psoriasis and adalimumab, a case report. Dermatology.
  • Migliore A., Bizzi E., Laganà B., Altomonte L., Zaccari G., Granata M., Canzoni M.,  Marasini B., Massarotti M., Massafra U., Ranieri M, Pilla R., Martin L.S., Pezza M., Vaccaand F. and Galluccio A.G. The safety of anti-TNF agents in the elderly. Int. J. Immunopathol. Pharmacol. 22(2), 415-426.
  • Galluccio A.G., Pilla R., Pezza M. Psoriasis during pregnancy and treatment with Etanercept: a clinical case. Psoriasis.
  • Guarnieri S., Pilla R., Morabito C., Sacchetti S., Fanò G and Mariggiò M.A. Extracellular Guanosine and GTP induce atypical differentiation in human SH-SY5Y neuroblastoma cells. Int. J. Devl. Neuroscience 27(2), 135-147.
  • Pilla R. The effect of extremely low frequency (ELF) electromagnetic fields on muscle differentiation. Tesionline.it URL:http://www.tesionline.it/default/tesi.asp?idt=28596.
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