Commentary 10.5281/zenodo.22847269

Epigenetics and Apoptosis in Development and Aging: Retrospective from the End of Last Century

Viktor I. Goudochnikov

This story began for us at the end of the decade of eighties when we became involved in studies on hormonal regulation in primary liver and pituitary cell cultures obtained from rats of different age groups: perinatal, prepubertal and adults. These studies continued later in vivo on somaitc and…...

Research Article 10.5281/zenodo.22843025

Postoperative Pain and Analgesic Requirements in Minimally Invasive Versus Open Gynaecological Procedures

Adeel Asghar

Background: One of the frequent problems after gynaecological surgery is postoperative pain which can have a significant impact on the patient's recovery, hospital stay and overall satisfaction. The use of minimally invasive gynaecological procedures such as Laparoscopic Surgery…...

Research Article 10.5281/zenodo.22842923

Synthetic Biology in Crop Production: Emerging Strategies for Precision and Sustainability

Adeel Asghar

Synthetic biology is transforming the field of crop improvement by allowing the precise control of genetic circuits, metabolic pathways, and regulatory networks. Unlike the conventional transgenic approaches, which involve the alteration of single genes, synthetic biology involves the…...

Research Article 10.5281/zenodo.22841974

Prevalence of Measles and Associated Healthcare System Factors in Chasefu District, Eastern Province, Zambia

Lweendo Makwamba, Chilufya Muya

Measles remains a major public health concern despite the availability of an effective vaccine. In Zambia, outbreaks continue to occur due to gaps in immunisation coverage, surveillance systems, and healthcare service delivery. Chasefu District has experienced recurrent measles cases despite…...

Case Report 10.5281/zenodo.23005426

Postextubation Upper-Airway Obstruction Leading to Negative-Pressure Pulmonary Edema and Hypoxic Cardiac Arrest Despite Apparent Recovery After Sugammadex Reversal: A Case Report

Kyung Soo Ha, Kyu Nam Kim

Postextubation upper-airway obstruction may cause negative-pressure pulmonary edema (NPPE) and, rarely, life-threatening cardiovascular collapse. Apparent clinical recovery after neuromuscular blockade reversal does not necessarily ensure adequate upper-airway function.

A 67-year-old…...

Research Article 10.5281/zenodo.22842182

Mesenchymal Stem Cell-Derived Exosomes in 3D-Bioprinted Hydrogel Scaffolds for Cartilage Regeneration: Advances, Mechanisms, and Translational Challenges

Adeel Asghar

Despite the current advances in the field, articular cartilage defects and osteoarthritis remain a challenge in the clinic due to the fact that mature cartilage lacks blood supply, is poorly cellular and has a weak intrinsic repair response. Although conventional treatments focusing on the…...

Review Article 10.5281/zenodo.22938708

Hidden Dimensions of Suffering Using a Theoretical Framework of Supersymmetry to Model Structural Determinants of Chronic Pain in Black Men

Christopher L. Edwards, Jasmine Benner, Kyla Whitten, et al.

Chronic pain in Black men remains poorly explained by biomedical models that treat tissue pathology as the primary driver of symptom severity and treatment outcome. Decades of clinical evidence document that Black men are underassessed for pain, undertreated with analgesics, disproportionately…...

Research Article 10.5281/zenodo.22842105

Plant Biotechnology in Pakistan Public Investments and Impacts on Pharmaceuticals and BT Cotton

Adeel Asghar

Pakistan, like other emerging nations, sees farmers weighing the pros and cons before adopting BT cotton. Given its benefits to Pakistani farmers, we anticipate similar advantages for small-scale cotton producers in many other developing countries. Another lesson from Pakistan underscores the…...

Review Article 10.5281/zenodo.22848045

Theoretical Investigation on NiF2 /Picolinic Acid-Catalyzed Chemoselective Coupling−Cyclization of 2‑Iodobenzamide and Malonate to Furnish Homophthalimide

Nan Lu

The first theoretical investigation on NiF2 /picolinic acid-catalyzed chemoselective cou-pling− cyclization of 2-iodobenzamide and malonate was provided by our DFT calculation. First in Ni(I)/ Ni(III) catalytic cycle, NiF2 and PicA are converted to L2 Ni(II) complex together with leaving of…...