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Editor Profile

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Dr. Xiangxuan Zhao, Ph.D.

Professor

Present

Liaoning University of Traditional Chinese Medicine (LUTCM)

Shenyang

China

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Dr. Xiangxuan Zhao is currently a Professor at Liaoning University of Traditional Chinese Medicine (LUTCM), doctoral supervisor, and postdoctoral mentor at LUTCM. In 2007, he graduated from the Institute of Zoology, Chinese Academy of Sciences, with a Ph.D. in Cell Biology, and subsequently pursued studies in the United States. From 2007 to 2012, he worked as a postdoctoral researcher at the University of Chicago and the University of Florida, specializing in cancer diagnosis and treatment research. He returned to China at the end of 2012 and has since focused his research on natural medicine derived from Chinese herbs, with an emphasis on tumor resistance and immunity: ① Mechanisms of tumor drug resistance; ② Development of molecular targeted anti-cancer drugs; ③ AI-driven research in Traditional Chinese Medicine (TCM).

Dr. Zhao has published a total of 89 papers (including 34 SCI papers, with a total impact factor (IF) of approximately 203; 5 papers with an IF >10, and the highest IF being 27.4; 1 ESI Highly Cited SCI paper, with total citations exceeding 1,000). He holds 13 granted national patents, with 4 as the first inventor. During his studies abroad, he received funding from the EPIG Award from the Department of Pathology, University of Florida, USA, and the AACR Training Award from the American Association for Cancer Research. After returning to China, he has served as the principal investigator for multiple projects funded by the National Natural Science Foundation of China (NSFC) and provincial/ministerial/departmental-level research initiatives.

  • Cancer Biology
  • Cancer Drug Resistance
  • Exosomes
  • Natural Products
  • Herb Medicine
  • YC Liu; R Guo, C Xue; XW Zhang; FH Xiao; XX Zhao*, Zhi Zhu*, Kai Li*, Phytosphingosine Suppresses Gastric Carcinogenesis Through SFRP4/β-Catenin Axis-Mediated Wnt Signaling Pathway Inhibition, Chemico-Biological Interactions, 2025, Nov 421(2025), 111749.
  • JR Yu#, W Sun#, XX Zhao*, YY Chen*. The therapeutic potential of RNA m(6)A in lung cancer, Cell Communication and Signaling, 2024 Dec 22 (1): 617.
  • HY Liang, LY Zhang, XX Zhao*, J Rong*. The therapeutic potential of exosomes in lung cancer. Cellular Oncology 2023 May 11, 46 (5): 1181-1212.
  • AX Ou#, XX Zhao#, ZM Lu*. Autophagy is involved in Ficus carica fruit extract-induced anti-tumor effects on pancreatic cancer. Biomedicine & Pharmacotherapy, 2022 Apr 12, 150: 112966.
  • AX Ou#, XX Zhao#, ZM Lu*. The potential roles of p53 reactivation in pancreatic cancer therapy. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2022 Jan, 1877(1): 188662.
  • C Sun, M Bai, WW Ke, XX Wang, XX Zhao*, ZM Lu*. The HSP90 inhibitor, XL888, enhanced cell apoptosis via downregulating STAT3 after insufficient radiofrequency ablation in hepatocellular carcinoma. Life Science, 2021 Oct 1, 282:119762.
  • LL Zhang, ZM Lu*, XX Zhao*. Targeting Bcl-2 for cancer therapy. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2021 Aug, 1876 (1): 188569.
  • HB Wang, XX Zhao*, ZM Lu*. m6A RNA methylation regulators act as potential prognostic biomarkers in lung adenocarcinoma. Frontiers in Genetics, 2021, 12: 622233.。
  • WW Ke#, HB Wang#, XX Zhao*, ZM Lu*. Foeniculum vulgare seed extract exerts anti-cancer effects on hepatocellular carcinoma. Food & Function, 2021 Mar, 12(4): 1482.
  • WW Ke, XX Zhao*, ZM Lu*. Foeniculum vulgare seed extract induces apoptosis in lung cancer cells partly through the down-regulation of Bcl-2. Biomedicine & Pharmacotherapy, 2021 Jan, 135:111213.
  • XX Zhao*, W Sun, Y Ren, ZM Lu. Therapeutic potential of p53 reactivation in cervical cancer. Critical Reviews in Oncology/Hematology, 2021 Nov, 157: 103182.
  • W Sun, Y Ren, ZM Lu, XX Zhao*. The potential roles of exosomes in pancreatic cancer initiation and metastasis, Molecular Cancer, 2020 Sept, 19: 135.
  • XX Zhao*, Y Ren, ZM Lu. Potential diagnostic and therapeutic roles of exosomes in pancreatic cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2020 Aug, 1874(2): 188414.
  • HB Wang#, ZM Lu#, XX Zhao*. Tumorigenesis, diagnosis, and therapeutic potential of exosomes in liver cancer. Journal of Hematology & Oncology, 2019 Dec, 12(1): 133. (ESI highly-cited paper)
  • XX Zhao#,*, WM Puszyk#, ZM Lu, D Ostrov, T George, K Robertson, C Liu*. Small molecule inhibitor YM155-mediated activation of death receptor 5 is crucial for chemotherapy-induced apoptosis in pancreatic carcinoma. Molecular cancer therapeutics, 2015, 14(1): 80-89.
  • XX Zhao*, Y Liu, L Du, BY Ni, LY He, JB Hu, DH Zhu, Q Chen*. Threonine 32 (Thr32) of FoxO3 is critical for TGF-β-induced apoptosis via Bim in hepatocarcinoma cells. Protein & Cell, 2015, 6(2): 127-138.
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