Background: Immunotherapy in un-resectable stage III NSCLC shows delayed treatment effects and time-varying hazards that challenge proportional-hazards assumptions. We developed a Continuous-Time Markov Chain (CTMC) model - with piecewise hazards - to capture the temporal dynamics of durvalumab after chemoradiotherapy (PACIFIC era), enabling transparent extrapolation beyond early trial landmarks.

Methods: We specified a multi-state CTMC with…

Background and Aims: Acne vulgaris is among the most prevalent inflammatory skin disorders worldwide and represents a substantial source of dermatologic morbidity and psychosocial distress, particularly among adolescents and young adults. This narrative review aimed to synthesize contemporary evidence on the epidemiology, molecular microbiology, pathogenesis, clinical diagnosis, management, prevention, and psychosocial burden of acne vulgaris, while also examining unresolved…

The credibility of science and the advancement of knowledge depend on scholarly publishing's integrity. Trust is the foundation of the whole publication process, from data collection and article drafting to peer review and editorial decision-making. However, a number of integrity issues threaten the validity of academic writing in many emerging research systems, including Nigeria. The main categories of misbehavior in journal publication are thoroughly examined in this work, including…

Six years after the World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) as a global pandemic, several key scientific and policy questions remain unresolved— an unsettling state of affairs given the inevitability of future pandemics. This Perspective examines five domains in which progress toward durable pandemic preparedness has stalled—not for lack of scientific innovation, but owing to fragmented data sharing, uneven translation of evidence into policy, and the…

Endometrial receptivity plays a key role in successful embryo implantation and is regulated by a combination of genetic and epigenetic mechanisms. This review aims to provide an overview of these regulatory processes and to highlight their relevance in clinical practice. In addition, current genomics-based diagnostic methods and emerging artificial intelligence-assisted approaches are discussed in relation to their potential use in evaluating endometrial receptivity. A literature review was…

Telemetry data that reflects the operational condition of onboard subsystems is continuously produced in vast quantities by satellite systems [1, 5]. For ensuring satellite reliability and preventing system failures, it is necessary to identify unusual trends in this data. Telemetry signals are frequently difficult for conventional anomaly detection techniques to handle because of their complicated temporal and multidimensional character. This study suggests a multimodal deep learning…

Background: Spinal arachnoid cysts are rare, benign cerebrospinal fluid–filled lesions that may cause spinal cord or nerve root compression. They are most frequently located in the thoracic region and typically present with a slow, insidious clinical course.

Case Description: We report the case of a 52-year-old man presenting with a 3-4-year history of progressive back pain and markedly reduced walking distance consistent with neurogenic…

Antimicrobial and bacteriolytic PGN cell wall destruction, hydrolysis, decomposition, and cleavage activities by metal salts, metal-based compounds/alloy materials have been extensively elucidated against S. aureus and E. coli.

Anti-microbial activity on metal salts: The antibacterial activity of Cu2+-treatment against Staphylococcus aureus was the most effective. Zn2+-treatment possessed a great antibacterial activity against S. aureus even, Cu2+ possessed the…

This study investigates the production of starch-based bioplastics from the mixture of potato and cassava peel waste starch using glycerol as plasticizer (20% wt/v) and comparing reinforcement with calcium carbonate and hydrochloric acid (4% wt/wt of filler to starch). The potato and cassava peel starch used in the production of the bioplastics were at a ratio of 3:1, 1 1, and 1:3 (wt/wt)), whereas the pure starches of the potato and cassava peel were studied as control. The physical…

Natural textile dyes, derived from plants, animals, and microorganisms, are increasingly used in food and nutrition to replace synthetic colorants due to their safety, sustainability, and health-promoting properties. These colorants (e.g., turmeric, beetroot, chlorophyll) often provide antioxidant, anti-inflammatory, and antimicrobial benefits.