Dr. Zhiling Yu holds a BSc degree in traditional Chinese medicine and a PhD degree in biochemistry. Dr. Yu is known for his research in herbal pharmacology, focusing on anti-atopic dermatitis, anti-rheumatic, and anticancerherbs.He is also interested in processing of Chinese medicinal materials.

• Melanoma
• Atopic Dermatitis
• Cancer
• Skin Care
• Pharmacology
• Inflammation

• Chen JL, Xiao YH, Wang KJ, Fu XQ, Fan YY, Hossen MJ, Chen YJ, Bai WB, Yu ZL, Xu BJ. Sea bass (Lateolabrax maculatus) exerts anti-ulcerative colitis effects through gut microbiota modulation. Food Front. 2024;1–13.
• Chen W, et al., Fu XQ, Yu ZL. A tri-herb formulation protects against ethanol-induced mouse liver injury and downregulates mitogen-activated protein kinase phosphatase 1. Phytomedicine. 2023;114:154802.
• Liu YX, et al., Dou X, Liu B, Yu ZL. Inhibition of STAT3 signaling contributes to the anti-melanoma effects of chrysoeriol. Phytomedicine. 2023 Jan;109:154572.
• Xiao C, Li K, Hua J, He Z, Zhang F, Li Q, Zhang H, Yang L, Pan S, Cai Z, Yu ZL, Wong KB, Xia Y. Arabidopsis DXO1 activates RNMT1 to methylate the mRNA guanosine cap. Nat Commun. 2023;14(1):202.
• Wu JY, et al., Yu ZL. Amelioration of TPA-induced skin inflammation by the leaf extract of Vernonia amygdalina involves ERK/STAT3 (Ser727) signaling inhibition. Phytomedicine. 2022;102:154194.
• Liu YX, et al., Yu ZL. Inhibition of Src/STAT3 signaling-mediated angiogenesis is involved in the anti-melanoma effects of dioscin. Pharmacol Res. 2022;175:105983.
• Zhang H; Zhong H; Wang X; Zhang S; Shao X; Hu H; Yu Z; Cai Z; Chen X; Xia Y. Use of NAD tagSeq II to identify growth-phase dependent alterations in E. coli RNA NAD+-capping. Proc Natl Acad Sci U S A. 2021;118:e2026183118.
• Amin A, Wu R, Cheung MH, Scott JF, Wang Z, Zhou Z, Liu C, Zhu G, Wong CK, Yu ZL, Liang C. An Essential and Cell-Cycle-Dependent ORC Dimerization Cycle Regulates Eukaryotic Chromosomal DNA Replication. Cell Rep., 2020; 30: 3323-3338.
• Fu XQ; et al,; Yu ZL. Cell Death Dis., 2020; 11: 1-15.
• Chen YJ; et al.; Yu ZL. An herbal formula inhibits STAT3 signaling and attenuates bone erosion in collagen-induced arthritis rats. Phytomedicine, 2020; 76:153254.
• Wu JY; Chen YJ; Bai L; Liu YX; Fu XQ; Zhu PL; Li JK; Chou JY; Yin CL; Wang YP; Bai JX; Wu Y; Wu ZZ; Yu ZL. Chrysoeriol ameliorates TPA-induced acute skin inflammation in mice and inhibits NF-κB and STAT3 pathways. Phytomedicine, 2020; 68:153173.
• Liu YX, Bai JX, Li T, Fu XQ, Guo H, Zhu PL, Chan YC, Chou JY, Yin CL, Li JK, Wang YP, Chen YJ, Yu ZL. A TCM formula comprising Sophorae Flos and Lonicerae Japonicae Flos alters compositions of immune cells and molecules of the STAT3 pathway in melanoma microenvironment. Pharmacol Res., 2019;142:115-126.
• Liu YX; Bai JX; Li T; Fu XQ; Chen YJ; Zhu PL; Chou JY; Yin CL; Li JK; Wang YP; Wu JY; Yu ZL. MiR-let-7a/f-CCR7 signaling is involved in the anti-metastatic effects of an herbal formula comprising Sophorae Flos and Lonicerae Japonicae Flos in melanoma. Phytomedicine, 2019; 64: 153084.
• Zhu PL; Zheng ZY; Fu XQ; Li JK; Yin CL; Chou JY; Wang YP; Liu YX; Chen YJ; Bai JX; Wu JY; Chen SB; Yu ZL. Arnicolide D Exerts Anti-Melanoma Effects and Inhibits the NF-κB Pathway. Phytomedicine, 2019; 64:153065.
• Liu JS; Huo CY; Cao HH; Fan CL; Hu JY; Deng LJ; Lu ZB; Yang HY; Yu LZ; Mo ZX; Yu ZL. Aloperine induces apoptosis and G2/M cell cycle arrest in hepatocellular carcinoma cells through the PI3K/Akt signaling pathway. Phytomedicine, 2019; 61: 152843.
• Zhu PL, Li JK, Fu XQ, Yu ZL. Schisandra fruits for the management of drug-induced liver injury in China: A review. Phytomedicine. 2018;59:152760.
• Kwan HY, Chao XJ, Su T, Fu XQ, Tse AK, Fong WF, Yu ZL. The anti-cancer and anti-obesity effects of Mediterranean diet. Crit Rev Food Sci Nutr. 2017;57:82-94.
• Tse AK, Chen YJ, Fu XQ, Su T, Li T, Guo H, Zhu PL, Kwan HY, Cheng BC, Cao HH, Lee SK, Fong WF, Yu ZL. Sensitization of melanoma cells to alkylating agent-induced DNA damage and cell death via orchestrating oxidative stress and IKKβ inhibition. Redox Biol. 2017;11:562-76.
• Cheng BCY, Fu XQ, Guo H, Li T, Wu ZZ, Chan, K, Yu ZL. The genus Rosa and arthritis: Overview on pharmacological perspectives. Pharmacol Res. 2016;114:219-234.
• Cao HH, Cheng CY, Su T, Fu XQ, Guo H, Li T, Tse AK, Kwan HY, Yu H, Yu ZL. Quercetin inhibits HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion. Mol Cancer. 2015;14:103.
• Kwan HY, Chao XJ, Su T, Fu XQ, Liu Bin, Tse KW, Fong WF, Yu ZL. Dietary Lipids and Adipocytes: Potential Therapeutic Targets in Cancers. J Nutr Biochem. 2015;26:303-11.
• Tse AW, Cao HH, Cheng CY, Kwan HY, Yu H, Fong WF, Yu ZL. Indomethacin Sensitizes TRAIL-Resistant Melanoma cells to TRAIL-induced Apoptosis through ROS-mediated Up-regulation of Death Receptor 5 and Down-regulation of Survivin. J Invest Dermatol. 2014;134:1397-407.
• Kwan HY, Fu X, Liu B, Chao X, Chan CL, Cao HH, Su T, Tse AK, Fong WF, Yu ZL. Subcutaneous adipocytes promote melanoma cell growth by activating Akt signaling pathway: role of palmitic acid. J Biol Chem. 2014;289:30525-37.
• Cao HH, Tse AK, Kwan HY, Yu H, Cheng CY, Su T, Fong WF, Yu ZL. Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling. Biochem Pharmacol. 2014;87:424-34.
• Tse AK, Chow KY, Cao HH, Cheng CY, Kwan HY, Yu H, Zhu GY, Wu YC, Fong WF, Yu ZL. The Herbal Compound Cryptotanshinone Restores Sensitivity in Cancer Cells that are Resistant to the Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand. J Biol Chem. 2013;288:29923-33.

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