LONGBING LING, PH.D.

Research Fellow, Emergency Medicine, UMICH

2800 Plymouth Rd Building 18, Ann Arbor, MI 48109

Phone: (+1) 734-239-3279

Email: linglongbing2023@gmail.com

PROFILE:

• Highly self-motivated Ph.D. candidate with demonstrated research expertise in artificial nanomedicines. Strong interpersonal skills.
• Experimental techniques: chemical synthesis, polymerization, cell culture, FCM, western blotting, real-time PCR, ELISA, cloning, recombinant protein, 125I-radioactivity labeling, CLSM, mice handling, dosing, and modeling.
• Rich experience in preparing and applying for the National Natural Science Foundation

EDUCATION:

University of Michigan-Ann Arbor, Michigan, United States

Research Fellow, Emergency Medicine, Advisor: Colin Greineder, 2023- Present.

Southeast University, Nanjing, China,

Ph.D. Chemical Engineering and Technology, Advisor: Xinsong Li, 2016-2019.

M.S. Pharmacoengineering, Advisor: Xinsong Li, 2013-2016.

School of Chemistry and Chemical Engineering.

Yantai University, Yantai, China

B.S. Polymerization, Advisor: Mengzhong Cui, 2009-2013.

Department of Polymer Materials and Engineering.

• Brain Drug Delivery
• Antibody Engineering
• Neuroinflammation
• Bio-responsive Materials/Formulation
• Cancer Immunotherapy
• Cell-mimicking Nanomedicine
• Bioinspired and Biomimetic Design

• Jianing Zhao†, Longbing Ling†,*, Wei Zhu, Yuan Du and Leiming Zhang, “M1/M2 Re-polarization of Kaempferol Biomimetic NPs in Anti-inflammatory Therapy of Atherosclerosis”. Journal of Controlled Release, 2023, 353: 1068-1083.
• Laien Zhao†, Longbing Ling†, Jing Lu, Feng Jiang, Jianchao Sun, Zhen Zhang, Yanmei Huang, Xiaoqian Liu, Yanjuan Zhu, Xiaoxuan Fu, Shengjun Peng, Wenze Yuan, Ruikang Zhao, Zhuhong Zhang*, “Reactive Oxygen Species-responsive Mitochondria-targeted Liposomal Quercetin Attenuates Retinal Ischemia-reperfusion Injury via Regulating SIRT1/FOXO3A and p38 MAPK Signaling Pathways”. Bioengineering & Translational Medicine, 2022: 10460.
• Jianing Zhao, Jian Ruan, Guangyao Lv, Qi Shan, Zhiping Fan, Hongbo Wang*, Yuan Du* and Longbing Ling*, “Cell Membrane-based Biomimetic Nanosystems for Advanced Drug Delivery in Cancer Therapy: A Comprehensive Review”. Colloids and Surfaces B: Biointerfaces, 2022, 215: 112503.
• Yanqin Song, Muhammad Ismail, Qi Shan, Jianing Zhao, Yanping Zhu, Leiming Zhang, Yuan Du* and Longbing Ling*, “ROS-mediated Liposomal Dexamethasone: A New FA-Targeted Nanoformulation to Combat Rheumatoid Arthritis via Inhibiting iRhom2/TNF-α/BAFF Pathways”. Nanoscale, 2021, 13(47): 20170-20185.
• Longbing Ling*, Haizhou Yu, Muhammad Ismail, Yanping Zhu, Yuan Du and Junhui Qi, “Synthetic Dimeric-Drug Phospholipid: A Versatile Liposomal Platform for Cancer Therapy”. Chemical Communications, 2020, 56(55): 7621-7624.
• Longbing Ling*, Muhammad Ismail, Zhihao Shang, Yihui Hu and Benhong Li, “Vitamin E-based Prodrug Self-Delivery for Nanoformulated Irinotecan with Synergistic Antitumor Therapeutics”. International Journal of Pharmaceutics, 2020, 577: 119049.
• Longbing Ling, Muhammad Ismail, YaweiDu, ChenYao and Xinsong Li*, “Lipoic acid-derived Cross-linked Liposomes for Reduction-Responsive Delivery of Anticancer Drug”. International Journal of Pharmaceutics, 2019, 560: 246-260.
• Longbing Ling, Muhammad Ismail, Yawei Du, Qing Xia, Chen Yao and Xinsong Li*, “High Drug Loading, Reversible Disulfide Core-cross-linked Multifunctional Micelles for Triggered Release of Camptothecin”. Molecular Pharmaceutics, 2018, 15(12): 5479-5492.
• Longbing Ling, Yawei Du, Muhammad Ismail, Ruiyu He, Yongpeng Hou, Zhenglin Fu, Ying Zhang, Chen Yao and Xinsong Li*, “Self-assembled Liposomes of Dual Paclitaxel-Phospholipid Prodrug for Anticancer Therapy”. International Journal of Pharmaceutics, 2017, 526(2): 11-22.
• Longbing Ling, Chen Yao, Yawei Du, Muhammad Ismail, Ruiyu He, Yongpeng Hou, Ying Zhang and Xinsong Li*, “Assembled Liposomes of Dual Podophyllotoxin Phospholipid: Preparation, Characterization and in vivo Anticancer Activity”. Nanomedicine, 2017, 12(6): 657-672.
• Shengjun Peng, Yizhou Wang, Zhifang Sun, Laien Zhao, Yanmei Huang, Xiaoxuan Fu, Rongrui Luo, Jianyue Xue, Shubin Yang*, Longbing Ling* and Zhuhong Zhang*, “Nanoparticles loaded with pharmacologically active plant-derived natural products: Biomedical applications and toxicity”, Colloids and Surfaces B: Biointerfaces, 2023, 225: 1132-1149.
• Zhi Wang†, Longbing Ling†, Qing Xia and Xinsong Li, “Disulfide-crosslinked Reduction-responsive Prodrug Micelles for on-demand Paclitaxel Release”. Journal of Drug Delivery Science and Technology, 2019, 53(21): 101168.
• Zhi Wang†, Longbing Ling†, Yawei Du, Chen Yao, and Xinsong Li*, “Reduction responsive liposomes based on paclitaxel-ss-lysophospholipid with high drug loading for intracellular delivery”, International Journal of Pharmaceutics, 2019, 564: 244-255.
• Muhammad Ismail, Longbing Ling, Yawei Du, Chen Yao and Xinsong Li*, “Liposomes of Dimeric Artesunate Phospholipid: A Combination of Dimerization and Self-Assembly to Combat Malaria”. Biomaterials, 2018, 163: 76-87.
• Wenya Zhou, Longbing Ling, Yawei Du, Wei He, Qing Xia, Chen Yao and Xinsong Li*, “Thiol-Mediated Multidentate Phosphorylcholine as A Zwitterionic Ligand for Stabilizing Biocompatible Gold Nanoparticles”. Langmuir, 2019, 35(40): 13031-39.
• Qing Xia, Longbing Ling, Muhammad Ismail, Yawei Du, Wei He, Wenya Zhou, Chen Yao and Xinsong Li*, “Paclitaxel encapsulated in artesunate-phospholipid liposomes for combinatorial delivery”, Journal of Drug Delivery Science and Technology, 2019, 51: 372-382.
• Man Li, Longbing Ling, Qing Xia and Xinsong Li*, “A Reduction-Responsive Drug Delivery with Improved Stability: Disulfide Crosslinked Micelles of Small Amphiphilic Molecules”. RSC Advances, 2021, 11(21): 12757-12770.
• Yawei Du, Longbing Ling, Muhammad Ismail, Wei He, Qing Xia, Chen Yao and Xinsong Li*, “Redox sensitive lipid-camptothecin conjugate encapsulated solid lipid nanoparticles for oral delivery”, International journal of pharmaceutics, 2018, 594(1-2): 352-362.
• Muhammad Ismail, Yawei Du, Longbing Ling and Xinsong Li*, “Artesunate-heparin conjugate based nanocapsules with improved pharmacokinetics to combat malaria”, International journal of pharmaceutics, 2019, 562: 162-171.
• Shuo Fang, Yongpeng Hou, Longbing Ling, Danquan Wang, Muhammad Ismail, Yawei Du, Ying Zhang, Chen Yao and Xinsong Li*, “Dimeric camptothecin derived phospholipid assembled liposomes with high drug loading for cancer therapy”, Colloids and Surfaces B: Biointerfaces, 2018, 166: 235-244.
• Yawei Zhang, Wei Zhang, Ruiyu He, Muhammad Ismail, Longbing Ling, Chen Yao and Xinsong Li*, “Dual 7-ethyl-10-hydroxycamptothecin conjugated phospholipid prodrug assembled liposomes with in vitro anticancer effects”, Bioorganic & medicinal chemistry, 2017, 25(12): 3247-3258.
• Ruiyu He, Yawei Du, Longbing Ling, Muhammad Ismail, Yongpeng Hou, Chen Yao and Xinsong Li, “Nanoformulation of dual bexarotene-tailed phospholipid conjugate with high drug loading”, European Journal of Pharmaceutical Sciences, 2017, 100: 197-204.
• Zhiping Fan*, Ping Cheng, Longbing Ling and Jun Han*, “Dynamic bond crosslinked poly (γ-glutamic acid)/Salecan derived hydrogel as a platform for 3D cell culture”, Materials Letters, 2020, 273: 127936.
• Yongpeng Hou, Chen Yao, Longbing Ling, Yawei Du, Ruiyu He, Muhammad Ismail, Ying Zhang, Zhenglin Fu and Xinsong Li*, “Novel dual VES phospholipid self-assembled liposomes with an extremely high drug loading efficiency”, Colloids and Surfaces B: Biointerfaces, 2017, 156: 29-37.
• Ruiyu He, Yawei Du, Longbing Ling, Muhammad Ismail, Yongpeng Hou, Chen Yao, Xinsong Li*, “Nanoformulation of dual bexarotene-tailed phospholipid conjugate with high drug loading”, European Journal of Pharmaceutical Sciences, 2017, 100: 197-204.
• Lu Lu, Yawei Du, Muhammad Ismail, Longbing Ling, Chen Yao, Zhenglin Fu, Xinsong Li*, “Nanoformulation of dual bexarotene-tailed phospholipid conjugate with high drug loading”, European Journal of Pharmaceutical Sciences, 2018, 112: 186-194.

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