Parvin Mehdipour

Full Professor

Female

    B.SC. in Biology;

    M.Sc.in Genetics

PhD in Medical Genetics (Cytogoenetics, Cancer Genetics), 1982, University of Liverpool, UK, Royal Liverpool Hospital (RLH).

Affiliation:

Department of Medical  Genetics, School of Medicine, Tehran  University of Medical Sciences,14155-6447, Zip code 14176-13151.Tehran, Iran. Email: mehdipor@tums.ac.ir

Fields:

• Human and Medical Genetics.
• Human cytogentics, molecuarcytogentics, Prenatal diagnosis.
• Cancer Genetics (inc. preventive), molecular Genetics, expression profiling.
• Creation of database on the basis of pedigrees, histopathologic data, clinical-, single cell-, and/or molecular-based.

Follow-up investigations in: (2000 Pedigrees, Breast cancer;brain; alimentary cancers- and thyroid-tumors; and Leukemias,….).

• ALL as pedigree-based.
• Dermatoglyphics (Finger print), Painting (hobby).

Languages: English, German

Number of post graduate theses supervising:

M.Sc. : 52

Ph.D : 26

MD : 8

• Cancer Genetics
• Human Genetics
• Medical Genetics
• Cytogenetics
• Nutri-genomics
• Gastronomy

• Mehdipour Parvin. Multi-Phase Based Signature and Cancer Management: An Insight Embryo, Brain Tumor, Leukemia, and Von Hippel Lindau Syndrome. Journal of Cancer Research Updates, 2023, 12, 54-64.
• Mehdipour P, Fathi N, Nosratabadi M. Personalized clinical managements through exploring circulating neural cells and electroencephalography. World J Exp Med 2023; 13(4): 75-94 [PMID: 37767542 DOI: 10.5493/wjem.v13.i4.75]. Novel finding: Initiation of Stem cell CD133 at embryonic level : ~6-th gestational week ; and chorionic villus sampling (CVS) at 9-12th week.
• Mehdipour, Parvin. Translating Single Cell Secrets to Cancer Evolution Accelerates Personalized Therapy. Medical Research Archives, [S.l.], v. 11, n. 8, aug. 2023. ISSN 2375-1924. Available at: <https://esmed.org/MRA/mra/article/view/4015>. Date accessed: 04 sep. 2023. doi: https://doi.org/10.18103/mra.v11i8.4015.
• Parvin Mehdipour, Evolutionary Hypothesis in Cell Cycle of Breast Cancer Patients: Mosaic Phases in Single Cancer Cells. Journal of Cancer Research Updates, 2022, 11, 43-53.
• Mehdi Zare, SeyedJamaleddinShahtaheri, Parvin Mehdipour, Shahram Zare. The influence of CYP1A1 and GSTM1 polymorphism on the concentration of urinary 1-hydroxypyrene in cPAHs exposed Iranian anode plant workers. 2013, Molecular and Cellular Toxicology 9(3):303-309. DOI: 10.1007/s13273-013-0038-8.
• Mehdipour P, Javan F, Faghih-Jouibari M, Mehdi Khaleghi M, Masoud Mehrazin M. Evolutionary model of brain tumor circulating cells: Cellular galaxy. World J Clin Oncol 2021 January 24; 12(1): 13-30. DOI: 10.5306/wjco.v12.i1.13 ISSN 2218-4333.
• Mehdipour P, Javan F, Faghih-Jouibari M, Mehdi Khaleghi M.Diversity in tumor territory of meningioma: Protein expression in vascular endothelial growth factor and epidermal growth factor.Iran J Neurol. ( Current j of Neurology)2019 Apr 4; 18(2): 43–49. PMCID: PMC6755502. PMID: 31565199.
• Mehdipour P, Azarnezhad A. Five-hit hypothesis in ATM gene: An individualized model in a breast cancer patient. Frontiers In Bioscience, Elite, 10, 375-383, March 1, 2018.
• Mehdipour P, Javan J, Estiar MA, Khaleghian M, Novin N, Zaeim Kohan H ,Akhondzadeh S. Protein Expression of ETS2 in Alzheimer’s Disease and Down ’s syndrome as a Personalized Insight: One Gene, One Feature in Common, Diverse-Function-and Diseases. SRL Neuro Neurosur. 2017;3(1): 001-007. DOI:10.3233/cbm-160546.
• AzarnezhadA, Tabrizi M, Atri, Mehdipour P*. ESR1 gene amplification in an Iranian population with early onset invasive ductal breast carcinoma. Breast cancer management 2018. DOI: 10.2217/bmt-2017-0018.
• Mehrdad AsghariEstiar, Parvin Mehdipour*. ATM in breast and brain tumors: a comprehensive review. Cancer Biol Med 2018. doi: 10.20892/j.issn.2095-3941.2018.0022.
• Pirouzpanah, Saeed, Taleban, Forough-Azam, Mehdipour, Parvin, Sabour, Siamak, Atri, Morteza. Hypermethylation pattern of ESR and PgR genes and lacking estrogen and progesterone receptors in human breast cancer tumors: ER/PR subtypes. Cancer Biomarkers, vol. Preprint, no. Preprint, pp. 1-18, 2017.
• Mehdipour P.*, Azarnezhad A. Eight-Hit Evolutionary Pattern in ATM Gene of a Breast Carcinoma Patient: A Personalized Approach. Journal of Cancer Research Updates, 2021, 10, 23-31.
• Nasser MM, Mehdipour P*. Exploration of Involved Key Genes and Signaling Diversity in Brain Tumors. Cell Mol Neurobiol. 2017 May 10. doi: 10.1007/s10571-017-0498-9. [Epub ahead of print] Review.PMID:28493234.
• Estiar MA, Javan F, Zekri A, Mehrazin M, Mehdipour P*. Prognostic significance of MYCN gene amplification and protein expression in primary brain tumors: Astrocytoma and meningioma. CancerBiomark.2017 Apr 19. doi: 10.3233/CBM-160546. [Epub ahead of print].
• Karimi B, Yunesian M, Nabizadeh R, Mehdipour P*, Aghaie A.Is Leukocyte Telomere Length Related with Lung Cancer Risk: A Meta-Analysis. Iran Biomed J. 2016 Nov 22. pii: Pii-IBJ-A-10-2008-1. [Epub ahead of print]PMID:27874106.
• HassanYousefi, Parvin Mehdipour*. Brief view of breast cancer in Iran: cross-road of genetics, cellular and cancer epidemiology. Volume 11 Issue 3 • July/August 2016.
• Kazemikhoo N, Sarafnejad A, Ansari F,Mehdipour P*. Modifying Effect of Intravenous Laser Therapy on the protein expression of Arginase and Epidermal Growth Factor Receptor in Diabetic Type 2 patients. Laser in Medicine. 2016( Accepted: 2016-06-24).
• Mehdipour P*, Javan F, Savad S, Karbassian H, Atri M. Personalized evolutionary hypothesis in genomics and auxiliary lymph node through diverse subtelomeric signal profile. Cell Biol Int. 2015 Jan 24. doi: 10.1002/cbin.10448. [Epub ahead of print] PMID: 25644206. doi: 10.1002/cbin.10448.
• Pirouzpanah S, Taleban FA, Mehdipour P*, Atri M. Association of folate and other one-carbon related nutrients with hypermethylation status and expression of RARB, BRCA1, and RASSF1A genes in breast cancer patients. J Mol Med (Berl). 2015 Aug;93(8):917-34.
• Bahrami Tayyeb, Mehdipour Parvin*. Pathogenesis of Breast Cancer Metastasis to Brain:a Comprehensive Approach to the Signaling Network. Mol Neurobiol (2016) 53:446–454.
• Mehdipour P, Karami F, Javan F, Mehrazin M (2014) Linking ATM promoter methylation to cell cycle protein expression: Cellular Molecular Triangle correlation in ATM territory. Mol Neurobiol (2015) 52:293-302. DOI: 10.1007/s12035-014-8864-9.
• Pishva H, Mehdipour P*, Eshraghian MR, Mahboob SA. Effects of Eicosapentaenoic Acid Supplementation on Lipid and Lipoprotein Profile in Hypertriglyceridemic Subjects with Different Proliferator-activated Receptor Alpha Genotypes. Int J Prev Med. 2014 Mar;5(3):333-40.
• Bahreini F, Soltanian AR, Mehdipour P*.A meta-analysis on concordance between immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) to detect HER2 gene overexpression in breast cancer. Breast Cancer. 2014 Apr 10. [Epub ahead of print].
• Mehdipour P*, Navidi I, Parsaeian M, Mohammadi Y, Moradi Lakeh M, Rezaei Darzi E, Nourijelyani K, FarzadfarF. Application of Gaussian Process Regression (GPR) in estimating under-five mortality levels and trends in Iran 1990 - 2013, study protocol. Arch Iran Med. 2014 Mar;17(3):189-92. doi: 0141703/AIM.009.
• Mohammadi Y, Parsaeian M, Farzadfar F, Kasaeian A, Mehdipour P*, Sheidaei A, Mansouri A, Saeedi Moghaddam S, Djalalinia S, Mahmoudi M, Khosravi A, Yazdani K. Levels and trends of child and adult mortality rates in the Islamic Republic of Iran, 1990-2013; protocol of the NASBOD study. Arch Iran Med. 2014 Mar;17(3):176-81. doi: 0141703/AIM.007.
• Fazilaty H, Mehdipour P*.Genetics of breast cancer bone metastasis: a sequential multistep pattern.Clin Exp Metastasis. 2014 Jun;31(5):595-612. doi: 10.1007/s10585-014-9642-9. Epub 2014 Feb 4. Review.
• P.Mehdipour*, F. Javan, M. Atri. Novel Evolutionary Models and Periodic Charts in p- and q-Individual Chromosomes of Auxiliary Lymph Node and Buccal Cells. Disease Markers, vol. 35, 2013, Issue 6, Pages 833–845.
• Fatemeh Karami and Parvin Mehdipour*, “A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer,” BioMed Research International, vol. 2013, Article ID 928562, 21 pages, 2013. doi:10.1155/2013/928562.
• Pirouzpanah S, Taleban FA, Mehdipour P*, Atri M, Hooshyareh-Rad A, Sabour S (2014) The biomarker-based validity of a food frequency questionnaire to assess the intake status of folate, pyridoxine and cobalamin among Iranian primary breast cancer patients. Eur J Clin Nutr 68:316-23.PMID:24169462.
• Schackert HK, Agha-Hosseini F, Görgens H, Jatzwauk M, von Kannen S, Noack B, Eckelt U, Hoffmann P, Shabestari SB, Mehdipour P. Complete homozygous deletion of CTSC in an Iranian family with Papillon-Lefèvresyndrome. Int J Dermatol. 2013 Apr 4. doi: 10.1111/j.1365-4632.2012.05769.x. [Epub ahead of print] No abstract available.
• Kheirollahi M, Mehrazin M, Kamalian N, Mohammadi-asl J, Mehdipour P*. Telomerase activity in human brain tumors: astrocytoma and meningioma. Cell Mol Neurobiol. 2013 May;33(4):569-74. doi: 10.1007/s10571-013-9923-x. Epub 2013 Mar 20.
• Parvin Mehdipour*, Saeed Pirouzpanah, A Azari Yam. Retinoic Acid Receptor b2 Gene in Breast Cancer. European journal of clinical & medical oncology 01/2012; 4(4):17-34.
• Dianatpour M, Mehdipour* P, Nayernia K, Mobasheri MB, Ghafouri-Fard S, Savad S, Modarressi MH. Expression of Testis Specific Genes TSGA10, TEX101 and ODF3 in Breast Cancer. Iran Red Crescent Med J. 2012 Nov;14(11):722-6. doi: 10.5812/ircmj.3611. Epub 2012 Nov 15.
• Savad S, Mehdipour*P, Miryounesi M, Shirkoohi R, Fereidooni F, Mansouri F, Modarressi MH. Expression analysis of MiR-21, MiR-205, and MiR-342 in breast cancer in Iran. Asian Pac J Cancer Prev. 2012; 13(3): 873-7.
• Tehranian N, Sepehri H, Mehdipour* P, Biramijamal F, Hossein-Nezhad A, Sarrafnejad A, HajizadehE.Combination effect of PectaSol and Doxorubicin on viability, cell cycle arrest and apoptosis in DU-145 and LNCaP prostate cancer cell lines.Cell Biol Int. 2012 Jul; 36(7): 601-10. doi: 10.1042/CBI20110309.
• Yazdee AK, Saedi B, Sazegar AA, Mehdipour*P. Epidemiological aspects of cleft lip and palate in Iran. Acta Med Iran. 2011 Jan;49(1):54-8.
• Mehdipour P*, Kheirollahi M, Mehrazin M, Kamalian N, Atri M (2011). Evolutionary hypothesis of telomere length in primary breast cancer and brain tumor patients: a tracer for genomic- tumor heterogeneity and instability. Cell Biology International 35: 915-925. Immediate publication.
• Koohdani F, Mehdipour P*. Micronucleus index of rats treated with sodium nitrite can be amplified by sodium chloride. J Exp Ther Oncol. 2011; 9(1): 75-9.
• Niroumanesh S, Mehdipour P, Farajpour A, Darvish S.A cytogenetic study of couples with repeated spontaneous abortions.Ann Saudi Med. 2011 Jan-Feb; 31(1): 77-9.
• Mehdipour P*, Pirouzpanah S, Kheirollahi M, Atri M. Androgen Receptor Gene CAG Repeat Polymorphism and Breast Cancer Risk in Iranian Women: A Case-Control Study. Breast J. 2011 Jan-Feb; 17(1): 39-46. doi: 10.1111/j.
• Pirouzpanah S, Taleban FA, Atri M, Abadi AR, Mehdipour P*. The effect of modifiable potentials on hypermethylation status of retinoic acid receptor-beta2 and estrogen receptor-alpha genes in primary breast cancer. Cancer Causes Control. 2010 Aug 15. [Epub ahead of print]PMID: 20711807 [PubMed - as supplied by publisher].
• Mohammadi-Asl J, Larijani B, Khorgami Z, Tavangar SM, Haghpanah V, Kheirollahi M, Mehdipour P*. Qualitative and quantitative promoter hypermethylation patterns of the P16, TSHR, RASSF1A and RARbeta2 genes in papillary thyroid carcinoma. Med Oncol. 2010 Jun 10.
• Mehdipour P, Mahdavi M, Mohammadi-Asl J, Atri M. Importance of ATM gene as a susceptible trait: predisposition role of D1853N polymorphism in breast cancer (200). Med Oncol..28: 733-737.
• Kheirollahi M, Mehhrazin M, Kamalian N, Mehdipour P* (2011). Alterations of telomere length in human brain tumors. Med Oncol28: 864-870.
• Pishva H, Mahboob SA, Mehdipour P*, Eshraghian MR, Mohammadi-Asl J, Hosseini S, Karimi F. Fatty acid-binding protein-2 genotype influences lipid and lipoprotein response to eicosapentaenoic acid supplementation in hypertriglyceridemicsubjects. Nutrition. 2010 Jan 15. [Epub ahead of print]PMID: 20080390 [PubMed - as supplied by publisher].
• Kheirollahi M, Mehr-Azin M, Kamalian N, Mehdipour P*. Expression of cyclin D2, P53, Rb and ATM cell cycle genes in brain tumors. Med Oncol. 2010 Jan 14. [Epub ahead of print]PMID: 20077038 [PubMed - as supplied by publisher].
• Koohdani F, Sasani F, Mohammad K, Mehdipour P*.Comparison of Ki-67 antigen expression and K-ras mutation in lung tumours induced by urethane in mice. Singapore Med J. 2009 Jul;50(7):729-33.PMID: 19644632.
• Mehdipour P*, Pirouzpanah S, Sarafnejad A, Atri M, Shahrestani ST, Haidari M. Prognostic implication of CDC25A and cyclin E expression on primary breast cancer patients. Cell Biol Int. 2009 Oct;33(10):1050-6.
• Hashemian AH, Hajizadeh E, Kazemnejad A, Atri M, Mehdipour P*. Penetrance of BRCA1/BRCA2 specific gene mutations in Iranian women with breast cancer. Saudi Med J. 2009 Jan; 30(1):41-4.
• KyumarsSafinejad, Nejat Mahdieh, Parvin Mahdipour, Leila Yadegar, MortezaAtri and Gholamreza Javadi. Sister chromatid exchange in peripheral blood lymphocytes as a possible breast cancer risk biomarker: A study of Iranian patients with breast cancer. Egypt. J. Med. Hum. Genet. Vol. 10, No. 1, May, 2009.
• Habibi, L. Ghoudsi, M. Sarraf Nejad, A.F Sharifi, R.andP. Mehdipour*. Analysis of Exon 19 and 39 of ATM Gene in Brain Tumors; Considering the P53 Accumulation in Patients with ATM Alteration. Journal of Sciences, Islamic Republic of Iran 19(3): 211-216 (2008).
• Mehdipour P*, Habibi L, Mohammadi-Asl J, Kamalian N, MehrAzin M. Three-hit hypothesis in astrocytoma: tracing the polymorphism D1853N in ATM gene through a pedigree of the proband affected with primary brain tumor. J Cancer Res Clin Oncol. 2008 Nov; 134(11):1173-80. Epub 2008 May 9. PMID: 18465141.
• Koohdani F, Baghdadchi J, Sasani F, Mohammad K, Mehdipour P*. Effects of vitamin D in lung, stomach, esophagus and testis tissues following administration of urethane in balb/c mice.Saudi Med J. 2008 Mar; 29(3):340-4.PMID: 18327356 [PubMed - indexed for MEDLINE] Related citations.
• Saadat M, Mehdipour P*.Correlation between IQ and dermatoglyphic indices of Down syndrome patients. Dermatol Online J. 2006 Oct 31;12(6):25.PMID: 17083905 [PubMed - indexed for MEDLINE] Related citations.
• Hosseini-Asl, Atri M, ModarressiMH, Salhab M, Mokbel K, Mehdipour P*(2006): The expression of hTR and hTERT in human breast cancer: correlation with clinico-pathological parameters. International Seminars in surgical Oncology, 3:20.
• Hosseini Asl, S. Modarressi MH, Atri M, SalhabM, Mokbel K, Mehdipour P* (2006):The association between telomerase activity and expression of its RNA component (hTR) in breast cancer patients: the importance of D Nase treatment. J Carcinog. 2;5:17.
• Mehdipour P*, Hosseini-Asl S, Savabi-E A, Habibi L, Alvandi E, Atri M (2006): Low Frequency of 185delAG Founder Mutation of BRCA1 Gene in Iranian Breast Cancer Patients. Journal of Cancer Molecules 2(3): 123-127.
• Mehdipour P*, Kalantar Motamedi MH , Beatrice Dette,Peters H: Genticsaspecte of cherubismus in an Iranian family: Mutations in the gene encoding c-Abl-binding protein (submitted).
• Behjati F, Atri M, Najmabadi H, Nouri K, Zamani M, Mehdipour P*.(2005):Prognostic Value of Chromosome 1 and 8 Copy Number in Invasive Ductal Breast Carcinoma among Iranian Women: An Interphase FISH Analysis. Pathol Oncol Res. 11(3):157-63.
• Andrea Pietschmann, Parvin Mehdipour*, MortezaAtri, Wera Hofmann S. Said Hosseini-Asl, Siegfried Scherneck, Hartmut Peters (2005): Mutation analysis of the BRCA1 and BRCA2 genes in Iranian high risk breast cancer families. J Cancer Res Clin Oncol. 131(8):552-8.
• Mehdipour P*, Atri M, Hosseini-Asl SS, Jafarimojarrad E, Javidroozi M (2003): Laddering through pedigrees: Family history of malignancies in primary breast cancer patients. APJCP, vol 4, No3:185-192.
• Atri M, Jafarimojarrad E, Javidroozi M, Mehdipour P* (2003): Lack of association between early onset of breast cancer and numbers of affected relatives in an Iranian population. Familial Cancer, Vol2, No2:117-118.
• Mehdipour P*, Mirfakhraie R, Atri M and Mehdipour AR (2003): KARYOTYPIC EVOLUTION: Cytogenetics Follow-Up Study In Childhood Acute Lymphoblastic Leukemia. APJCP 4:358-368.
• Mirfakhraie R, Atri M, Mehdipour P* (2002): Cytogenetic abnormalities in the lymphocytes of a female patient with primary breast cancer. Cancer Genetics and Cytogenetics, 132: 169-170.
• Atri M, Mehdipour P*, Javidroozi M, Hosseini-Asl SS, Jafarimojarrad E (2002): Linking Histopathology and Family History in Breast Cancer. APJCP, 3:33-40.
• Atri M, Mehdipour P*, Mosavi-Jarrahi AR (2001): The role of family history of neoplastic disorders among hundred patients with primary breast cancer. Med J I Hospital, 3, 2:1-5.
• Mehdipour P*, Atri M, Nassarizadeh H, Hashemi S, TavousiGh R (2001): Cancer Genetics Epidemiology and Genetics investigation in colorectal carcinomas: Directions towards prevention. Gouvaresh J, 33/34: 115-119.
• Mehdipour P*,Atri M, Pourfarzad F (1999): Detection of BRCA1 gene in BC-probands by PCR-SSCP. Arch I Med J, 2, 2: 67-70.
• Mehdipour P*, Karimi AR, Bastanhagh MH (1996): Perrault’s syndrome: A clinical and Genetic investigation of three sisters. Acta Med Iranica, 37, 2: 78-85.
• Mehdipour P, Atri M (1996): Fluorescence in situ hybridization (FISH) in Iranian patients with primary breast cancer. Acta Med Iranica, ¾: 80-82.
• Mehdipour P*, Saadat M, Noori-Daloi MR(1996): Down’s syndrome: Cytogenetics investigation in 150 cases.Med J Isl R I, 10, 1: 47-52.
• Schwanitz G, Mehdipour P*, Schwbert R (1996): Abnormal differentiation of the chorion and its relevance to….I J Pub Hlth, 25, 1-2.
• Azari S, Mehdipour P,Abbassi A (1991): Cesarean section and the Cytogenetics investigation of anIschiopagus Tetrabrachius Tripus. Ir J Med Sci, 16, 1-2:87-90.
• Mehdipour P*, Nasseri J, Farhi F (1989): Prenatal diagnosis; Chorionic Villi Sampling (CVS). Sh.Beh Univ Med Sci, J FAC Med, 12, 3,4:137-144.
• Korn E, Schwanitz G, Bauer M, Mehdipour P* (1987): Comparative studies on the arrangement of chromosomes in the C-metaphase between normal karyotype and trisomy-21.Ir J Pub Hlth 16, 1-4: 25-56.
• Mehdi6pour P*,Farhud D (1985): Apert’s syndrome (Acrocephalosyndactyly type 1).Ir j Peditrics 1, 3: 297-303.
• Satchi G, Mainwaring D, Mehdipour P (1982): Acute Lymphoblastic Leukaemia in children: Chromosome, immunological markers and clinical significances. Lab Haematolo, 4: 87-94.
• Saadat M, Mehdipour P*.Correlation between IQ and dermatoglyphic indices of Down syndrome patients. Dermatol Online J. 2006 Oct 31;12(6):25.PMID: 17083905 [PubMed - indexed for MEDLINE] Related citations.
• Mostafa Saadat, Parvin Mehdipour* (2006). Correlation between IQ and dermatoglyphic indices of Down syndrome patients. Dermatol Online J.,. 31;12(6):25.PMID: 17083905.
• Mehdipour P*, Farhud D (1979): A Dermatoglyphic study of Iranian Moslems, Part II: Palmar main-lines, patterns and Axial Triradius. Coll Anthropol, 3, 1 : 113-117.
• Mehdipour P*, Farhud D (1978): A Dermatoglyphic study of Iranian Moslems, Part I:Finger patterns and ridge-counts.Ir J Pub Hlth 7, 4:196-206.

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