I am currently a Resident and Research Assistant at the Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine. I completed my Bachelor of Stomatology and Bachelor of Law at Binzhou Medical College from 2013 to 2018. I then pursued my Master’s and Doctoral degrees in Clinical Science of Stomatology at Shanghai Jiao Tong University from 2018 to 2024.

My research focuses on Craniomaxillofacial Repair and Reconstruction, Head and Neck Tumor Microenvironment, the role of the Microbiome in Oral Diseases, and the Application of Bioinformatics Analysis in Oral and Systemic diseases. I have participated in several research projects, including those funded by the National Natural Science Foundation of China and the Provincial Natural Science Foundation of China. I am also an active member of various academic organizations and serve on the Editorial Boards of multiple international journals.

• Craniomaxillofacial Repair and Reconstruction
• Head and Neck Tumor Microenvironment
• Microbiome and Oral Diseases
• Bioinformatics Analysis in Oral and Systemic Diseases

• Wang Z, Li L, Yang S, Li Z, Zhang P, Shi R, Zhou X, Tang X, Li Q. Possiblemechanisms of SARS-CoV-2-associated myocardial fibrosis: reflections in thepost-pandemic era. Front Microbiol. 2024 Oct 8;15:1470953. doi:10.3389/fmicb.2024.1470953. PMID: 39444690; PMCID: PMC11497467.
• Gopinath D, Pandiar D, Li Z, Panda S. Rodent models for oral microbiomeresearch: considerations and challenges- a mini review. Front Oral Health. 2024Oct 1;5:1439091. doi: 10.3389/froh.2024.1439091. PMID: 39421460; PMCID:PMC11484444.
• Li Z, Wang Q, Huang X, Wu Y, Shan D. Microbiome's role in musculoskeletalhealth through the gut-bone axis insights. Gut Microbes. 2024 Jan-Dec;16(1):2410478. doi: 10.1080/19490976.2024.2410478. Epub 2024 Oct 10. PMID:39387683; PMCID: PMC11469435.
• Li Z, Li J, Huang X. Clinical trial landscape for periodontitis treatment:Trend analysis and future perspectives. J Transl Med. 2024 Oct 7;22(1):907. doi:10.1186/s12967-024-05697-4. PMID: 39375793; PMCID: PMC11457384.
• Li Z, Li J, Bai X, Huang X, Wang Q. Tumor microenvironment as a complexmilieu driving cancer progression: a mini review. Clin Transl Oncol. 2024 Sep28. doi: 10.1007/s12094-024-03697-w. Epub ahead of print. PMID: 39342061.
• Shen G, Wang Q, Li Z, Xie J, Han X, Wei Z, Zhang P, Zhao S, Wang X, Huang X,Xu M. Bridging Chronic Inflammation and Digestive Cancer: The Critical Role ofInnate Lymphoid Cells in Tumor Microenvironments. Int J Biol Sci. 2024 Sep9;20(12):4799-4818. doi: 10.7150/ijbs.96338. PMID: 39309440; PMCID: PMC11414386.
• Wu Y, Mohd Sani SB, Peng K, Lin T, Tan C, Huang X, Li Z. Research progress ofthe Otubains subfamily in hepatocellular carcinoma. Biomed Pharmacother. 2024Oct;179:117348. doi: 10.1016/j.biopha.2024.117348. Epub 2024 Aug 28. PMID:39208669.
• Zhang J, Han H, Liu Y, Xu J, Zhang D, Wang W, Gao Y, Li Z, Qin Y. SKF96365Inhibits Tumor Proliferation by Inducing Apoptosis and Autophagy in HumanEsophageal Squamous Cell Carcinoma. Int J Genomics. 2024 Aug 13;2024:4501154.doi: 10.1155/2024/4501154. PMID: 39165489; PMCID: PMC11335422.
• Li Z, Zhang Y, Huang X, Gopinath D. MRE11 as a plausible biomarker andprognostic bioindicator for head and neck squamous cell carcinoma. J StomatolOral Maxillofac Surg. 2024 Oct;125(5S2):101970. doi:10.1016/j.jormas.2024.101970. Epub 2024 Jul 19. PMID: 39032645.
• Shan D, Li Z, Wang C. New four year direct entry medical degree: prudence isneeded. BMJ. 2024 Jul 18;386:q1598. doi: 10.1136/bmj.q1598. PMID: 39025503.
• Zhou Z, Mai Y, Zhang G, Wang Y, Sun P, Jing Z, Li Z, Xu Y, Han B, Liu J.Emerging role of immunogenic cell death in cancer immunotherapy: Advancing next-generation CAR-T cell immunotherapy by combination. Cancer Lett. 2024 Aug28;598:217079. doi: 10.1016/j.canlet.2024.217079. Epub 2024 Jun 25. PMID:38936505.
• Zhou Z, Zhang G, Xu Y, Yang S, Wang J, Li Z, Peng F, Lu Q. The underlyingmechanism of chimeric antigen receptor (CAR)-T cell therapy triggering secondaryT-cell cancers: Mystery of the Sphinx? Cancer Lett. 2024 Aug 10;597:217083. doi:10.1016/j.canlet.2024.217083. Epub 2024 Jun 24. PMID: 38925363.
• Zhou Z, Wang J, Wang J, Yang S, Wang R, Zhang G, Li Z, Shi R, Wang Z, Lu Q.Deciphering the tumor immune microenvironment from a multidimensional omicsperspective: insight into next-generation CAR-T cell immunotherapy and beyond.Mol Cancer. 2024 Jun 26;23(1):131. doi: 10.1186/s12943-024-02047-2. PMID:38918817; PMCID: PMC11201788.
• Zhou Z, Zhang G, Wang Z, Xu Y, Qin H, Zhang H, Zhang P, Li Z, Xu S, Tan X,Zeng Y, Yu F, Zhu S, Chang L, Zheng Y, Han X. Molecular subtypes of ischemicheart disease based on circadian rhythm. Sci Rep. 2024 Jun 19;14(1):14155. doi:10.1038/s41598-024-65236-5. PMID: 38898215; PMCID: PMC11187219.
• Li Z, Liu Y, Huang X, Wang Q, Fu R, Wen X, Liu J, Zhang L. F. Nucleatumenhances oral squamous cell carcinoma proliferation via E-cadherin/β-Cateninpathway. BMC Oral Health. 2024 May 2;24(1):518. doi: 10.1186/s12903-024-04252-3.PMID: 38698370; PMCID: PMC11064238.
• Huang X, Yang J, Wang Q, Fu R, Wen X, Li Z, Zhang L. Disulfidptosis in headand neck squamous carcinoma: Integrative bioinformatic and in-vitro analysis.Oral Dis. 2024 Nov;30(8):4993-5006. doi: 10.1111/odi.14977. Epub 2024 May 2.PMID: 38696646.
• Zheng T, Liu C, Wang Y, Zhou H, Zhou R, Zhu X, Zhu Z, Tan Y, Li Z, Huang X,Tan J, Zhu K. Inflammatory cytokines mediating the effect of oral lichen planuson oral cavity cancer risk: a univariable and multivariable mendelianrandomization study. BMC Oral Health. 2024 Mar 22;24(1):375. doi:10.1186/s12903-024-04104-0. PMID: 38519926; PMCID: PMC10958829.
• Wang T, Li Z, Zhao S, Liu Y, Guo W, Alarcòn Rodrìguez R, Wu Y, Wei R.Characterizing hedgehog pathway features in senescence associated osteoarthritisthrough Integrative multi-omics and machine learning analysis. Front Genet. 2024Feb 20;15:1255455. doi: 10.3389/fgene.2024.1255455. PMID: 38444758; PMCID:PMC10912584.
• Li Z, Wang Q, Huang X, Wu Y, Fu R, Wen X, Liu J, Chen Y, Liu Y, Zhang L. AMendelian Randomisation Analysis Reveals No Relationship Between Periodontitisand Coronary Atherosclerosis. Int Dent J. 2024 Aug;74(4):705-712. doi:10.1016/j.identj.2024.01.027. Epub 2024 Mar 2. PMID: 38431470; PMCID:PMC11287172.
• Wang Q, Zheng C, Hou H, Bao X, Tai H, Huang X, Li Z, Li Z, Wang Q, Pan Q,Wang L, Zhou S, Bian Y, Pan Q, Gong A, Xu M. Interplay of SphingolipidMetabolism in Predicting Prognosis of GBM Patients: Towards PrecisionImmunotherapy. J Cancer. 2024 Jan 1;15(1):275-292. doi: 10.7150/jca.89338. PMID:38164288; PMCID: PMC10751665.
• Fu R, Li Z, Liu J, Zhang L. Surgery alone is feasible for oral andmaxillofacial SS-LCH: A retrospective analysis. Asian J Surg. 2024Mar;47(3):1520-1521. doi: 10.1016/j.asjsur.2023.11.157. Epub 2023 Dec 7. PMID:38065733.
• Li Z, Li J, Fu R, Liu J, Wen X, Zhang L. Halitosis: etiology, prevention,and the role of microbiota. Clin Oral Investig. 2023 Nov;27(11):6383-6393. doi:10.1007/s00784-023-05292-9. Epub 2023 Oct 16. PMID: 37843633.
• Zhang D, Wang M, Huang X, Wang L, Liu Y, Zhou S, Tang Y, Wang Q, Li Z, WangG. GLS as a diagnostic biomarker in breast cancer: in-silico, in-situ, and in-vitro insights. Front Oncol. 2023 Aug 18;13:1220038. doi:10.3389/fonc.2023.1220038. PMID: 37664031; PMCID: PMC10471892.
• Li Z, Wang Q, Huang X, Fu R, Wen X, Zhang L. Multi-omics analysis revealsthat ferroptosis-related gene CISD2 is a prognostic biomarker of head and necksquamous cell carcinoma. J Gene Med. 2024 Jan;26(1):e3580. doi:10.1002/jgm.3580. Epub 2023 Aug 15. PMID: 37581006.
• Huang X, Liu Y, Wang Q, Rehman HM, Horváth D, Zhou S, Fu R, Zhang L,Szöllősi AG, Li Z. Brief literature review and comprehensive bioinformaticsanalytics unravel the potential mechanism of curcumin in the treatment ofperiodontitis. BMC Oral Health. 2023 Jul 8;23(1):469. doi:10.1186/s12903-023-03181-x. PMID: 37422651; PMCID: PMC10329799.
• Li Z, Fu R, Huang X, Wen X, Zhang L. Oral microbiota may affectosteoradionecrosis following radiotherapy for head and neck cancer. J TranslMed. 2023 Jun 17;21(1):391. doi: 10.1186/s12967-023-04219-y. PMID: 37328857;PMCID: PMC10276415.
• Li Z, Fu R, Huang X, Wen X, Zhang L. A decade of progress: bibliometricanalysis of trends and hotspots in oral microbiome research (2013-2022). FrontCell Infect Microbiol. 2023 May 12;13:1195127. doi: 10.3389/fcimb.2023.1195127.PMID: 37249977; PMCID: PMC10213461.
• Wang Q, Liu Y, Li Z, Tang Y, Long W, Xin H, Huang X, Zhou S, Wang L, LiangB, Li Z, Xu M. Establishment of a novel lysosomal signature for the diagnosis ofgastric cancer with in-vitro and in-situ validation. FrontImmunol. 2023 May 5;14:1182277. doi: 10.3389/fimmu.2023.1182277. PMID: 37215115;PMCID: PMC10196375.
• Liu Y, Zhou S, Wang L, Xu M, Huang X, Li Z, Hajdu A, Zhang L. Machinelearning approach combined with causal relationship inferring unlocks the sharedpathomechanism between COVID-19 and acute myocardial infarction. FrontMicrobiol. 2023 Mar 29;14:1153106. doi:10.3389/fmicb.2023.1153106. PMID:37065165; PMCID: PMC10090501.
• Li Z, Wang Q, Huang X, Yang M, Zhou S, Li Z, Fang Z, Tang Y, Chen Q, Hou H,Li L, Fei F, Wang Q, Wu Y, Gong A. Lactate in the tumor microenvironment: Arising star for targeted tumor therapy. Front Nutr. 2023 Feb 16;10:1113739. doi:10.3389/fnut.2023.1113739. PMID: 36875841; PMCID: PMC9978120.
• Wang Q, Li Z, Zhou S, Li Z, Huang X, He Y, Zhang Y, Zhao X, Tang Y, Xu M.NCAPG2 could be an immunological and prognostic biomarker: From pan-canceranalysis to pancreatic cancer validation. Front Immunol. 2023 Jan 27;14:1097403.doi: 10.3389/fimmu.2023.1097403. PMID: 36776838; PMCID: PMC9911455.
• Li Z, Fu R, Wen X, Wang Q, Huang X, Zhang L. The significant clinicalcorrelation of the intratumor oral microbiome in oral squamous cell carcinomabased on tissue-derived sequencing. Front Physiol. 2023 Jan 9;13:1089539. doi:10.3389/fphys.2022.1089539. PMID: 36699672; PMCID: PMC9868672.
• Li Z, Fu R, Wen X, Zhang L. Network analysis reveals miRNA crosstalk betweenperiodontitis and oral squamous cell carcinoma. BMC Oral Health. 2023 Jan13;23(1):19. doi: 10.1186/s12903-022-02704-2. PMID: 36639776; PMCID: PMC9840318.
• Fu R, Wen X, Li Z, Zhang L. MALT lymphoma of the head and neck: Surgeryalone can be an option. Oral Oncol. 2023 Jan;136:106258. doi:10.1016/j.oraloncology.2022.106258. Epub 2022 Nov 21. PMID: 36423465.
• Li Z, Liu Y, Zhang L. Role of the microbiome in oral cancer occurrence,progression and therapy. Microb Pathog. 2022 Aug;169:105638. doi:10.1016/j.micpath.2022.105638. Epub 2022 Jun 17. PMID: 35718272.
• Wen X, Hu Y, Liu Y, Li Z, Mai H, Zhang L. Conservative treatment of head andneck lymphoma is not the only effective treatment: A retrospective analysis of301 cases. Oral Oncol. 2022 May;128:105828. doi:10.1016/j.oraloncology.2022.105828. Epub 2022 Mar 25. PMID: 35344710.
• Liu Y, Li Z, Qi Y, Wen X, Zhang L. Metagenomic Analysis Reveals a ChangingMicrobiome Associated With the Depth of Invasion of Oral Squamous CellCarcinoma. Front Microbiol. 2022 Feb 9;13:795777. doi:10.3389/fmicb.2022.795777. PMID: 35222330; PMCID: PMC8863607.
• Li Z, Liu Y, Zhang L. Comment on the "Aapplication of "Hand as Foot"teaching method in facial nerve anatomy". Asian J Surg. 2022 Feb;45(2):824-825.doi: 10.1016/j.asjsur.2021.12.017. Epub 2021 Dec 29. PMID: 34973860.
• Li Z, Liu Y, Zhang L, Liu R. The "Hand as Foot" teaching method inmandibular condyle anatomy. Asian J Surg. 2022 Jan;45(1):649-650. doi:10.1016/j.asjsur.2021.11.008. Epub 2021 Dec 1. PMID: 34863594.
• Li Z, Liu Y, Zhang L, Liu R. Application of the "Hand as Foot" analogymethod in teaching the anatomy of palatine bones. Asian J Surg. 2022Feb;45(2):733-734. doi: 10.1016/j.asjsur.2021.11.022. Epub 2021 Nov 29. PMID:34857458.
• Li L, Tang Y, Qiu L, Li Z, Wang R. Extracellular matrix shapes cancer stem cell behavior in breast cancer: a mini review. Front Immunol. 2025;15:1503021. Published 2025 Jan 9. doi:10.3389/fimmu.2024.1503021
• Liu S, Huang X, Wang L, Li Z. Unraveling the Genetic Link: Exploring the Causal Relationship Between Periodontitis and Allergic Rhinitis. Int J Rheum Dis. 2025;28(1):e70011. doi:10.1111/1756-185X.70011
• Li Z, Huang X, Wang Q, Gopinath D. Causal Association Between Microbiome and Oral-Oropharyngeal Cancer: A Mendelian Randomization Study. Int Dent J. Published online February 21, 2025. doi:10.1016/j.identj.2025.01.017
• Zhou Z, Wang Z, Peng F, Chen S, Yang S, Li Z, Xu Y, Qin H, Wang J, Lu Q, Xu R. The association between obstructive sleep apnea and nocturnal enuresis in children: current advances and research trends. World J Urol. 2025 Mar 10;43(1):158. doi: 10.1007/s00345-025-05541-4. PMID: 40064684.
• Lin A, Ding Y, Li Z, Jiang A, Liu Z, Wong HZH, Cheng Q, Zhang J, Luo P. Glucagon-like peptide 1 receptor agonists and cancer risk: advancing precision medicine through mechanistic understanding and clinical evidence. Biomark Res. 2025 Mar 27;13(1):50. doi: 10.1186/s40364-025-00765-3. PMID: 40140925; PMCID: PMC11948983.
• Qiu Z, Li Z, Zhang C, Zhao Q, Liu Z, Cheng Q, Zhang J, Lin A, Luo P. NK Cell Senescence in Cancer: From Molecular Mechanisms to Therapeutic Opportunities. Aging Dis. 2025 Apr 12. doi: 10.14336/AD.2025.0053. Epub ahead of print. PMID: 40249925.
• Li J, Luo P, Li Z, Wang Q, Huang X, Wang K, Wang R, Chen R. Extrachromosomal Circular DNA in Cancer: Mechanisms and Clinical Applications. Cell Prolif. 2025 Apr 29:e70040. doi: 10.1111/cpr.70040. Epub ahead of print. PMID: 40300805.
• Fu R, Li Z, Liu J, Xu B, Wen X, Zhang L. Potential mechanism of inhibitory effect of "medicine food homology" curcumin and its analogue EF24 on oral squamous cell carcinoma. Clin Transl Oncol. 2025 May 2. doi: 10.1007/s12094-025-03871-8. Epub ahead of print. PMID: 40314923.
• Li J, Li Z, Wang K. Targeting angiogenesis in gastrointestinal tumors: strategies from vascular disruption to vascular normalization and promotion strategies angiogenesis strategies in GI tumor therapy. Front Immunol. 2025 Apr 22;16:1550752. doi: 10.3389/fimmu.2025.1550752. PMID: 40330478; PMCID: PMC12052729.
• Li ZR, Wang YF, Zuo CR, Men JS, Li XY, Luo P, Su XS, Sun RF. Unlocking the potential of immune checkpoint inhibitors in advanced cervical cancer: a meta-analysis and systematic review. BMC Cancer. 2025 May 13;25(1):863. doi: 10.1186/s12885-025-14264-z. PMID: 40355848; PMCID: PMC12070727.

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