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Prof. Joan-Lluis Vives-Corrons, M.D., Ph.D.

Emeritus Professor

Present

Universitat de Barcelona

Barcelona

Spain

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Prof. Joan-Lluis Vives-Corrons, MD, PhD is Emeritus Prof. at the University of Barcelona and honorary researcher at the Josep Carreras Institute for Leukaemia Research (IJC). His professional activity has centered on rare anemias and other hematologic diseases.

For over 30 years, he was the head of the Haematology Laboratory Department (1976-1997) and the Red Blood Cell Pathology Unit (1998-2016) at the Hospital Clinic of Barcelona. As principal investigator of 35 research projects has focused on the molecular and genetic mechanisms of red blood cell (RBC) disorders as the hereditary hemolytic anemias, including enzymopathies, membranopathies, and hemoglobinopathies.

In 2002, he coordinated the European Network for Rare and Congenital Anaemias (ENERCA), sponsored by the EC, establishing a pan-European platform for rare anemia clinical care and research. In 2016, ENERCA contributed to the creation of EuroBloodNet, the EU’s Reference Network for Rare Hematological Diseases. He now chairs the Scientific Board of the Rare Anemias International Network (RAIN).

Prof. Vives-Corrons has authored over 300 scientific publications and played a key role in the establishment of the official Newborn Screening Program for Sickle-Cell Disease in Catalonia (2015). Since 2017, as an emeritus professor, he continues his research on rare anemias at the IJC.

  • Hereditary Hemolytic Anemias
  • Red Blood Cell Disorders
  • Erythropoiesis
  • Ektacytometry
  • Rare Anemias
  • Hemoglobinopathies
  • Membranopathies
  • Enzymopathies
  • Genetic Diagnosis
  • Red Cell Pathophysiology
  • Angastiniotis M, Vives Corrons JL, Soteriades ES, Eleftheriou A. The impact of migrations on the health services for rare diseases in Europe: the example of haemoglobin disorders. Scientific World Journal.;2013:727905, 2013
  • Vives-Corrons JL, Briggs C, Simon-Lopez R, Albarede S, de la Salle B, Flegar-Meatrii Z, Nazor A, Guyard A, Lipsic T, Nagai Y, Patiu M, Piqueras J, Capel MJ, Van Blerk M, Wang J, Marzac C. Effect of EDTA-anticoagulated whole blood storage on cell morphology examination. A need for standardization. Int J Lab Hematol. 36(2):222-6, 2014
  • Vives-Corrons JL, Koralkova P, Grau JM, Mañú Pereira Mdel M, Van Wijk R First description of fosphofructokinase deficiency in spain: identification of a novel homozygous missense mutation in the PFKM gene. Front Physiol. 30;4:393, 2013
  • Mañú-Pereira Mdel M, Gonzalez-Roca E, van Solinge WW, Llaudet-Planas E, Sevilla J, Montllor L, Mensa-Vilaro A, Ploos van Amstel HK, van Wijk R, Vives-Corrons J. Pyruvate kinase deficiency and severe congenital hemolytic anemia in a double heterozygous patient with paternal transmission of an early germ-line de novo mutation. Am J Hematol. 90(12):E217-9, 2015
  • Garcia-Gomez M, Calabria A, Garcia-Bravo M, Benedicenti F, Kosinski P, López-Manzaneda S, Hill C, Del Mar Mañu-Pereira M, Martín MA, Orman I, Vives-Corrons JL, Kung C, Schambach A, Jin S, Bueren JA, Montini E, Navarro S, Segovia JC. Safe and Efficient Gene Therapy for Pyruvate Kinase Deficiency. Mol Ther. 24(7):1187-98, 2016
  • Koralkova P, Mojzikova R, van Oirschot B, Macartney C, Timr P, Vives Corrons JL, Striezencova Laluhova Z, Lejhancova K, Divoky V, van Wijk R. Molecular characterization of six new cases of red blood cell hexokinase deficiency yields four novel mutations in HK1. Blood Cells Mol Dis.59:71-6, 2016
  • Makhro A, Huisjes R, Verhagen LP, Mañú-Pereira Mdel M, Llaudet-Planas E, Petkova-Kirova P, Wang J, Eichler H, Bogdanova A, van Wijk R, Vives-Corrons JL, Kaestner L. Red Cell Properties after Different Modes of Blood Transportation. Front Physiol. 15;7:288, 2016
  • Ceriotti F, Fernandez-Calle P, Klee GG, Nordin G, Sandberg S, Streichert T, Vives-Corrons JL, Panteghini M; EFLM Task and Finish Group on Allocation of laboratory tests to different models for performance specifications (TFG-DM). Criteria for assigning laboratory measurands to models for analytical performance specifications defined in the 1st EFLM Strategic Conference. Clin Chem Lab Med. pii: /j/cclm.ahead-of-print/cclm-2016-0091/cclm-2016-0091.xml. doi: 10.1515/cclm-2016-0091. [Epub ahead of print] 2016
  • Montllor l, Mañú-Pereira M, Llaudet-Planas E, Gómez Ramírez P, Sevilla Navarro J, Vives-Corrons Jl. Déficit de piruvato cinasa eritrocitaria en España: Estudio de 15 casos Medicina Clínica 2016. 148: 23-27. DOI: 10.1016/j.medcli.2016.10.004
  • Ceriotti F, Fernandez-Calle P, Klee GG, Nordin G, Sandberg S, Streichert T, Vives-Corrons JL, Panteghini M. (2017) Criteria for assigning laboratory measurands to models for analytical performance specifications defined in the 1st EFLM Strategic Conference 2017 Clin Chem Lab Med 55:189-194. doi: 10.1515/cclm-2016-0091.
  • Hertz L, Huisjes R, Llaudet-Planas E, Petkova-Kirova P, Makhro A, Danielczok JG, Egee S, del Mar Mañú-Pereira M, van Wijk R, Vives Corrons J-L, Bogdanova A and Kaestner L 2017) Is increased intracellular calcium in red blood cells a common component in the molecular mechanism causing anemia? Front. Physiol 8:673-78.doi: 10.3389/fphys.2017.0067
  • Vives corrons JL Mañú Pereira MM, Trujillo JP, Surrallés J, Sevilla J. Arbor 2018 (libro): 194 (789): a463. https://doi.org/10.3989/arbor.2018.789n3005
  • Petkova-kirova p, Hertz l, Makhro a, Danielczok j, Huisjes r, Llaudet-Planas E, Mañu-Pereira MM, Vives Corrons JL, van Wijk R, Bogdanova A, Kaestner l. A previously unrecognized ca2+-inhibited nonselective cation channel in red blood cells. Hemasphere. 2018; 38 :1-5. http://dx.doi.org/10.1097/hs9.0000000000000146
  • Llaudet-Planas E, Vives-Corrons JL, Rizzuto V, Gómez-Ramírez P, Sevilla Navarro J, Coll Sibina MT, García-Bernal M, Ruiz Llobet A, Badell I, Velasco-Puyó P, Dapena JL, Mañú-Pereira MM . Int J Lab Hematol. 2018 40:94-102. doi: 10.1111/ijlh. 12746.
  • Vives Corrons JL The Rare Anemias 2019. Book Chapter. Intech Open DOI:http://dx.doi.org/10.5772/intechopen.8698
  • Rachael F. Grace, MD, Bianchi P, Glader B, Glenthøj A, Jones B, Kanno H, Kelvin H. Kuo M, Layton M, van Beers EJ, Vives Corrons JL An ongoing global, longitudinal, observational study of patients with pyruvate kinase deficiency: The peak registry. Blood. 2019; 134 (Supplement_1): 2223. https://doi.org/10.1182/blood-2019-123059
  • Krishnevskaya, E, Rodríguez-Hernández I, Serra A, Payán-Pernía S, Rizzuto, V. Magariño, M, Vives-Corrons, JL. Severe hereditary haemolytic anaemia due to three novel spta1 mutations in two compound heterozygous unrelated patients. Hema Sphere 2019; 3:548-549. DOI:10.1097/01.HS9.0000563100.74550.a7
  • De Sanctis V, Soliman AT, Canatan D, Yassin MA, Daar S, Elsedfy H, Di Maio S, Raiola G, Corrons JV, Kattamis C. Thyroid disorders in homozygous β-thalassemia: current knowledge, emerging issues and open problems. Mediterr J Hematol Infect Dis 2019; 11(1):e2019029. doi:http://dx.doi.org/10.4084
  • Payán-Pernía S, Krishnevskaya W, Rizzuto V, Remacha A, Torrent M, Badell I, Agueda A, Vives-Corrons JL Hereditary ellyptocytosis associated with heterozygote pyruvate kinase and glucose-6-phosphate dehidrogenase mutations. a case report and family study. Hema Sphere ,2019; 3 (S1) p 894-995. doi: 10.1097/01.HS9.0000566364.10825.27
  • Petkova-Kirova P, Hertz L, Danielczok J, Huisjes R, Makhro A, Bogdanova A, Mañú-Pereira MDM, Vives Corrons JL, van Wijk R, Kaestner L. Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias. Front Physiol. 2019; 16;10:386. doi: 10.3389/fphys.2019.00386.
  • Canatan D, De Sanctis V, Vives Corrons JL The EQUALITY project on endocrine complications in thalassemia. Ped. Endocrinol. Rev. 2019 ;16:401-411. doi:10.17458/per.vol16.2019.csc.mr.thalassemia
  • De Sanctis V, Canatan D, Corrons JLV, Karimi M, Daar S, Kattamis C, Soliman AT et al . A comprehensive update of ICET-A Network on COVID-19 in thalassemias: what we know and where we stand (2020). Acta Biomed: 7;91(3):e2020026. doi: 10.23750/abm.v91i3.10063.
  • De Sanctis V, Canatan D, Corrons JLV, Karimi M, Daar S, Kattamis C, Soliman AT, et al Preliminary data on covid-19 in patients with hemoglobinopathies: A multicentre ICET-A study Mediterr J Hematol Infect Dis 2020 1;12(1):e2020046. doi: 10.4084/MJHID.2020.046.
  • Vives Corrons JL, De Sanctis V. Rare anaemias, Sickle-cell disease and Covid-19. Acta Biomed 2020 May 11;91(2):216-217. doi: 10.23750/abm.v91i2.9532,
  • Huisjes R, Makhro A, Llaudet-Planas E, Hertz L, Petkova-Kirova P, Verhagen LP, Pignatelli S,1 Rab MAE, Schiffelers RM, Seiler E, van Solinge WW, Vives Corrons JL, Kaestner L, Mañú-Pereira M, Bogdanova A and van Wijk R Huisjes 2020 spherocytosis haematologica. Haematologica. 2020 105(2):338-47. doi:10.3324/haematol.2018.188151.
  • Krishnevskaya E, Rizzuto V, Payán-Pernía S, Remacha Á, Torrent M, Ruiz A, Badell I, Vives Corrons JL Coinheritance of hereditary ellyptocytosis, pyruvate kinase, and glucose‐6‐phosphate dehidrogenase mutations. A rare anemia diagnostic paradigm. Int J Lab Hematol 2020; 42(2):e55-e58.doi:10.1111/ijlh.13110. Epub 2019 Sep 20.
  • Huisjes R, Makhro A, Llaudet-Planas E, Hertz L, Petkova-Kirova P, Verhagen LP, Pignatelli S, Rab MAE, Schiffelers RM, Seiler E, van Solinge WW, Corrons JV, Kaestner L, Mañú-Pereira M, Bogdanova A, van Wijk R .Density, heterogeneity and deformability of red cells as markers of clinical severity in hereditary spherocytosis. Haematologica. 2020 31;105(2):338-347. doi: 10.3324/haematol.2018.188151.
  • Requena-Méndez, A., Bisoffi, Z., Vives-Corrons, J.-L., Gascon, J., Plasència, A European expert network on rare communicable diseases and other rare diseases linked to mobility and globalisation focused on health care provision (EURADMOG): A feasibility study. Orphanet Journal of Rare Diseases.2020; 15 (1), art. No 291. https://www.scopus.com/inward/record.uri.DOI: 10.1186/s13023-020-01534-1
  • Canatan D, Vives Corrons JL, De Sanctis V The multifacets of covid-19 in adult patients: a concise clinical review on pulmonary and extrapulmonary manifestations for healthcare physicians. Acta Biomed 2020 10;91(4):e2020173. doi: 10.23750/abm.v91i4.10665.
  • Vives-Corrons JL, Krishnevskaya E. Rare anemias in adolescents. Acta Biomed 2021; 18;92(1):e2021169. doi: 10.23750/abm.v92i1.11345.
  • Vives Corrons JL, Berga Casafont L, Feliu Frasnedo E. Concise review : How do red blood cells born,live and die ?. Ann Hematol 2021; 100(10):2425-33. doi: 10.1007/s00277-021-04575-z.
  • Canatan D, Vives Corrons JL, Piacentini G, Kara F, Keskinkılıç B, Tezel B, Külekçi Uğur A, Babayiğit M, Krishnevskaya E, Millimaggi G, Erinekçi O, Özdemir Z, De Sanctis V mmigration and screening programs for hemoglobinopathies in Italy, Spain and Turkey. Acta Biomed 2021; 92(4):e2021410. doi: 10.23750/abm.v92i4.11965.
  • Krishnevskaya E, Payán-Pernía S, Hernández-Rodríguez I, Remacha Sevilla ÁF, Ancochea Serra Á, Morales-Indiano C, Serra Ferrer M, Vives-Corrons JL Distinguishing iron deficiency from beta‐thalassemia trait by new generation ektacytometry. Int J Lab Hematol 2021; Apr;43(2):e58-e60. doi: 10.1111/ijlh.13362. Epub 2020 Oct 22. PMID: 33089959.
  • Jaffredo T, Balduini A, Bigas Anna, Bernardi Rosa, Bonnet Dominique, Vives Corrons et al The EHA Research Roadmap: Normal Hematopoiesis. Hema Sphere 2021; 5:12 - p e669. doi: 10.1097/HS9.0000000000000669.
  • Méndez-Mora L, Cabello-Fusarés M, Ferré-Torres J, Riera-Llobet C, Krishnevskaya E,rejo-Soto C, Payán-Pernía S, Hernández-Rodríguez I, Morales-Indiano C, Alarcón T, Vives-Corrons JL, Hernandez-Machado A Blood rheological characterization of β-thalassemia trait and iron deficiency anemia using front microrheometry. Front Physiol. 2021; 21;12:761411. doi: 10.3389/fphys.2021.761411.
  • Vives-Corrons JL, Krishnevskaya E, Rodriguez IH, Ancochea A. Characterization of hereditary red blood cell membranopathies using combined targeted next-generation sequencing and osmotic gradient ektacytometry. Int J Hematol 2021; 113(2):163-174. doi: 10.1007/s12185-020-03010-9.
  • Krishnevskaya E, Molero Magariño M, Ancochea Serra Á, Vives Corrons JL, Hernandez I, Leguizamón V. (2022) New generation ektacytometry study of red blood cells rheological parameters in hemoglobinopathies. Hemasphere 2022; 23;6(Suppl):1431-32.doi: 10.1097/01.HS9.0000849056.33045.a2
  • Bianchi, P, Grace, R. F, Vives Corrons JL, Glader B, Glenthøj A, Kanno, H, Kuo, K, Lander C, Layton D, Pospíŝilová D. Viprakasit V.Williams J, Yan Y, McGee B, van Beers, E.J. Characterizing iron overload by age in patients diagnosed with pyruvate kinase deficiency – A descriptive analysis from the peak registry.Hema Sphere.2022; 6: 1443-44. doi:10.1097/01.HS9.0000849104.75259.69.
  • Vives Corrons JL, Krishnevskaya E, Montllor L, Leguizamon V, Garcia Bernal M Concomitant hereditary spherocytosis and pyruvate kinase deficiency in a Spanish family with chronic hemolytic anemia. Contribution of laser ektacytometry to clinical diagnosis. Cells 2022; 28;11(7):1133-36. doi: 10.3390/cells11071133. PMID: 35406697.
  • Vives-Corrons JL, Krishnevskaya E, Hernández-Rodriguez I, Payán-Pernia S, Sevilla ÁFR, Badell I Red cell ektacytometry in two patients with chronic hemolytic anemia and three new α-spectrin variants.Ann Hematol 2022; 101(3):549-55. doi: 10.1007/s00277-021-04723-5.
  • Jorda L, Montllor L, Krisnevskaya E, Leguizamón V, Hernandez I, Gelpi, J, Vives Corrons JL (2022) Conformational study of pyruvate kinase deficient variants with hemolytic anemia. The relationships between the loss of enzyme function and structural disruption. Hema Sphere 2022; 6:1432-33. doi: 10.1097/01.HS9.0000849060.64856.dd
  • Vives Corrons JL, Krishnevskaya E Congenital defects with impaired red blood cell deformability. The role of next generation ektacytometry. Book Chapter Intech Open 2023.
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