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Mr. Akeem Sanni

Ph.D. Candidate

Present

Texas Tech University

Texas

United States

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Akeem Sanni earned his B.S. in Biochemistry with summa cum laude honors from Olabisi Onabanjo University in 2018, where he was recognized as the Best Graduating Student of his department. He is currently pursuing his Ph.D. in Bioanalytical Chemistry at Texas Tech University under the supervision of Prof. Yehia Mechref. His doctoral research focuses on the Development and Application of Multi-Omics Strategies for Biomarker Discovery in Neurological Disorders and Cancer. Akeem Sanni has made significant contributions to the identification of protein, glycan, and metabolite biomarkers for neurological disorders such as Narcolepsy type 1, Restless Leg Syndrome, Alzheimer's disease, and Traumatic Brain Injury. He also contributed to the glycomic profiling of the SARS-CoV-2 spike protein across multiple variants. Akeem Sanni developed an optimized bioanalytical method for the targeted analysis of tumor-maker gangliosides in pediatric, breast, and pancreatic cancer. He has published several peer-reviewed articles (10+) in journals including ACS Omega, Cells, Biomolecules, Journal of Neurorestoratology, and Neurotrauma Reports, and contributed to 2 book chapters in Methods in Molecular Biology (Springer Nature). His work has been presented at over nine major scientific conferences, including ASMS, ACS, and the ITP Symposium. Akeem Sanni has served as a reviewer for several high-impact SCI journals, including Scientific Reports, PLOS ONE, Mycotoxin Research, and Phytoparasitica. In addition to his research, his recognition includes the Doctoral Dissertation Completion Fellowship, the Ming Sun Family Graduate Research Award, and the Ginny Shen Lin Award of Academic Excellence. He is a member of several professional organizations, including the American Society for Biochemistry and Molecular Biology, the American Association of Cancer Research, the American Society for Mass Spectrometry, and the American Neurological Association.

  • Proteomics
  • Glycomics
  • Metabolomics
  • Lipidomics
  • LC-MS/MS
  • Hakim, M.A.; Sanni, A.; Osman, S.T.; Hamdy, N.A.; Purba, W.T.; Bhuiyan, M.A.; Onigbinde, S.; L.K., Belal.; El-Khordagui, L.K.; El-Yazbi, A.; Mechref, Y., Serum Proteome Profiling of Diabetic Patients Treated with DPP4 and SGLT2 Inhibitors Show Improved Cognitive, and Cardiovascular Functions. (Accepted in Proteomics, 2025)
  • Goli, M.; Sanni, A.; Gautam, S.; Mallah, K.; Hubbard, W.B.; Reslan, M.; Haidar, M.A.; Halabi, K.; Walker, J.; Mondello, S.; Kobeissy, F.; Mechref, Y., Exploring the Impact of Mitoquinone Supplementation on Glycan Profiles in a Repeated Mild Traumatic Brain Injury Mouse Mode. Neurotrauma Rep 2025, 6, (1), 525-538.
  • Hakim, M. A.; Purba, W.; Sanni, A.; Bhuiyan, M. M. A. A.; Talih, F.; Lanza, G.; Kobeissy, F.; Plazzi, G.; Pizza, F.; Ferri, R.; Mechref, Y., Alteration of Metabolic Profile in Patients with Narcolepsy Type 1. Metabolites 2025, 15, (6), 382.
  • Sanni, A.; Bennett, A. I.; Huang, Y.; Gidi, I.; Adeniyi, M.; Nwaiwu, J.; Kang, M. H.; Keyel, M. E.; Gao, C.; Reynolds, C. P.; Haab, B.; Mechref, Y., An Optimized Liquid Chromatography-Mass Spectrometry Method for Ganglioside Analysis in Cell Lines. Cells 2024, 13, (19), 1640.
  • Mogavero, M. P.; Fowowe, M.; Sanni, A.; Goli, M.; Lanza, G.; L'Episcopo, F.; Ferini-Strambi, L.; Mechref, Y.; Ferri, R., Evidence of Involvement of the Calcitonin Gene-Related Peptide in Restless Legs Syndrome. Mov Disord 2025, 40, (6), 1148-1159.
  • Sanni, A.; Hakim, M. A.; Goli, M.; Adeniyi, M.; Talih, F.; Lanuzza, B.; Kobeissy, F.; Plazzi, G.; Moresco, M.; Mondello, S.; Ferri, R.; Mechref, Y., Serum N-Glycan Profiling of Patients with Narcolepsy Type 1 Using LC-MS/MS. ACS Omega 2024, 9, (30), 32628-32638.
  • Nwaiwu, J.; Ibeh, S.; Reslan, M. A.; Bakkar, N.-M. Z.; Nasrallah, L.; Eid, A. H.; Mekhjian, S.; Sanni, A.; Haidar, M. A.; Goli, M.; Obeid, O.; El Khoury, R.; Mechref, Y.; El-Yazbi, A. F.; Kobeissy, F., Western diet induces mild metabolic impairment and aggravates neuropathology in an experimental mouse model of traumatic brain injury. Journal of Neurorestoratology 2024, 12, (3), 100140.
  • Gutierrez Reyes, C. D.; Sanni, A.; Mogut, D.; Adeniyi, M.; Ahmadi, P.; Atashi, M.; Onigbinde, S.; Mechref, Y., Targeted Analysis of Permethylated N-Glycans Using MRM/PRM Approaches. Methods Mol Biol 2024, 2762, 251-266.
  • Gutierrez Reyes, C. D.; Sanni, A.; Adeniyi, M.; Mogut, D.; Najera Gonzalez, H. R.; Ahmadi, P.; Atashi, M.; Onigbinde, S.; Mechref, Y., Targeted Glycoproteomics Analysis Using MRM/PRM Approaches. Methods Mol Biol 2024, 2762, 231-250.
  • Sanni, A.; Goli, M.; Zhao, J.; Wang, J.; Barsa, C.; El Hayek, S.; Talih, F.; Lanuzza, B.; Kobeissy, F.; Plazzi, G.; Moresco, M.; Mondello, S.; Ferri, R.; Mechref, Y., LC-MS/MS-Based Proteomics Approach for the Identification of Candidate Serum Biomarkers in Patients with Narcolepsy Type 1. Biomolecules 2023, 13, (3).
  • Reyes, C. D. G.; Onigbinde, S.; Sanni, A.; Bennett, A. I.; Jiang, P.; Daramola, O.; Ahmadi, P.; Fowowe, M.; Atashi, M.; Sandilya, V.; Hakim, M. A.; Mechref, Y., N-Glycome Profile of the Spike Protein S1: Systemic and Comparative Analysis from Eleven Variants of SARS-CoV-2. Biomolecules 2023, 13, (9).
  • Sanni, A. A.; Ige, O. M.; Olagunju, G. B.; Olukade, B. A., Partially Purified 3-Mercaptopyruvate Sulphurtransferase Obtained from the Intestine of Cane Rat (Thryonomys swinderianus) as a Detoxifier of Cyanide. Asian Journal of Biochemistry, Genetics and Molecular Biology 2020, 6, (2), 1-9.
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