Dr. Yongting Luo, Ph.D., Associate Professor, Doctoral Supervisor.

Address:

Department of Nutrition and Health

China Agricultural University

Beijing 100193, China

Email: luo_yongting@163.com; luo.yongting@cau.edu.cn

Education:

2003-2007 -  Bachelor, College of life sciences, Sichuan University.

2007-2012 -  PhD, Institute of biophysics, Chinese academy of sciences.

Appointment:

2012-2014 - Research Assistant, Institute of biophysics, Chinese Academy of sciences.

2014-2016 - Research Associate, Institute of biophysics, Chinese Academy of sciences.

2016 -  Associate Professor, China Agricultural University.

Research Interest:

Cardiovascular surgery, vascular biology, therapeutic target, cardiovascular diseases, aortic dissection, and atherosclerosis, bioactive nutrients, nutritional intervention, cell metabolism, cell signaling, mitochondria.

Social Appointment:

Peer Review Expert of National Natural Science Foundation.

Peer Review Expert of Beijing Natural Science Foundation.

Expert in Thesis Review of the Ministry of Education.

National Graduate Education Evaluation Expert.

Beijing Agricultural Science and Technology Expert.

Membership:

Member of the American Society for Nutrition (ASN).

Member of the European Society of Cardiology (ESC).

Reviewer Service:

Nature Communications, PNAS, Signal Transduction and Targeted Therapy, Clinical and Translational Medicine, American Journal of Clinical Nutrition, Biomedicines, Biomolecules, Cells, European Journal of Pharmacology, Pharmaceuticals, Life Sciences, Nutrients, FASEB Journal.

Editorial Experience:

Guest Editor: Antioxidants, Frontiers in Nutrition, Nutrients.

Editorial Board Member: Cardiology and Cardiovascular Research, Nutrients.

• Cardiovascular Surgery
• Vascular Biology
• Therapeutic Target
• Cardiovascular Diseases
• Aortic Dissection and Atherosclerosis
• Bioactive Nutrients
• Nutritional Intervention
• Cell Metabolism
• Cell Signaling
• Mitochondria

• Yongting Luo*, Junjie Luo*, Peng An*, Yuanfei Zhao*, Wenting Zhao*, Zhou Fang, Yi Xia, Lin Zhu, Teng Xu, Xu Zhang, Shuaishuai Zhou, Mingyan Yang, Jiayao Li, Junming Zhu, Yongmin Liu, Haiyang Li, Ming Gong, Yuyong Liu, Jie Han, Huiyuan Guo#, Hongjia Zhang#, Wenjian Jiang#, Fazheng Ren#. The AP-1 complex governs a vascular degenerative transcriptional program in smooth muscle cells to trigger aortic dissection and rupture. Eur Heart J. 2024 Jan 27;45(4):287-305.
• Lin Zhu*, Dongjie Li*, Xu Zhang, Sitong Wan, Yuyong Liu, HongJia Zhang, Junjie Luo#, Yongting Luo#, Peng An#, Wenjian Jiang#. Comparative efficacy on outcomes of C-CABG, OPCAB and ONBEAT in coronary heart disease: A systematic review and network meta-analysis of randomized controlled trials. Int J Surg. 2023 Sep 18. doi: 10.1097/JS9.0000000000000715.
• Teng Xu*, Xu Zhang*, Wenting Zhao, Sitong Wan, Jingjing He, Li Jiang, Hao Wang, Yanling Hao, Hong Gao#, Junjie Luo#, Yongting Luo#, Peng An#. Foxo1 is an iron-responsive transcriptional factor regulating systemic iron homeostasis. Blood. 2024 Jun 7:blood.2024024293.
• Wenting Zhao*, Juan Chen*, Yi Xia*, Sitong Wan, Yanling Hao, Fazheng Ren#, Peng An#, Yongting Luo#, Junjie Luo#. Temporal-specific single cell atlas of human type A aortic dissection reveals immune cell dynamics and therapeutic targets. Science Bulletin. 2024 Jul 4:S2095-9273(24)00462-6.
• Luo Y, Duan H, Qian Y, Feng L, Wu Z, Wang F, Feng J, Yang D, Qin Z, Yan X#. Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis. Cell Research. 2017;27(3):352-372.
• Jianan Chen*, Yongting Luo*, Hui Hui, Tanxi Cai, Hongxin Huang, Fuquan Yang, Jing Feng, Jingjing Zhang#, Xiyun Yan#. CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development. Proc Natl Acad Sci U S A. 2017;114(36):E7622-E7631.
• Yongting Luo#, Xiao Teng, Lingling Zhang, Jianan Chen, Zheng Liu, Xuehui Chen, Shuai Zhao, Sai Yang, Jing Feng, Xiyun Yan#. CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension. Nature Communications. 2019, 7;10(1):3551.
• Wenyi Xu, Huijuan Hua, Yueh-Ho Chiu, Guannan Li, Huihan Zhi, Zhengquan Yu, Fazheng Ren, Yongting Luo#, Wei Cui#. CD146 regulates growth factor-induced mTORC2 activity independent of PI3K and mTORC1 pathways. Cell Reports. 2019, 29;29(5):1311-1322.
• Lingling Zhang*, Yongting Luo*, Xiao Teng, Zhenzhen Wu, Mengtao Li, Dong Xu, Qian Wang, Fei Wang, Jing Feng#, Xiaofeng Zeng#, Xiyun Yan#. CD146: a potential therapeutic target for systemic sclerosis. Protein & Cell, 2018 ;9(12):1050-1054.
• Jianan Chen*, Yongting Luo*, Hongxin Huang, Shuilong Wu, Jing Feng, Jingjing Zhang, Xiyun Yan#. CD146 is essential for PDGFRβ-induced pericyte recruitment. Protein & Cell, 2018;9(8):743-747.
• Wenting Zhao*, Juan Chen*, Yi Xia, Sitong Wan, Yanling Hao, Fazheng Ren#, Peng An#, Yongting Luo#, Junjie Luo#. Temporal-specific single cell atlas of human type A aortic dissection reveals immune cell dynamics and therapeutic targets. Science Bulletin. Accepted.
• Xuan Wang*, Yuting Ji*, Jingyi Qi, Shuaishuai Zhou, Sitong Wan, Chang Fan, Peng An#, Yongting Luo#, Junjie Luo#. Mitochondrial carrier 1 (MTCH1) governs ferroptosis by triggering the FoxO1-GPX4 axis-mediated retrograde signaling in cervical cancer cells. Cell Death & Disease. 2023 Aug 8;14(8):508.
• Xu T, Zhang X, Liu Y, Wang H, Luo J#, Luo Y#, An P#. Effects of dietary polyphenol supplementation on iron status and erythropoiesis: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr. 2021 Apr 19:nqab068.
• Jingyi Qi*, Shuaishuai Zhou*, Zi Wang, Yi Xia, Tiancheng Xu, Yinhua Zhu, Yanling Hao, Peng An#, Junjie Luo#, Yongting Luo#. Dendrobium officinale polysaccharide alleviates atherosclerosis by modulating metabolic homeostasis and gut microbiota. Antioxidants. 2024, 13(5), 599.
• Shuaishuai Zhou, Zi Wang, Yanling Hao, Peng An, Junjie Luo#, Yongting Luo#. Dandelion polysaccharides ameliorated high-fat-diet-induced atherosclerosis in mice through antioxidant and anti-inflammatory capabilities. Nutrients. 2023. 15(19):4120.
• Junjie Luo#, Yongting Luo#. The Effects of Dietary Protein and Polysaccharide Fortification on Disease. Nutrients. 2023. 15(19):4137.
• Jingyi Qi, Peng An, Dekui Jin, Yuting Ji, Sitong Wan, Xu Zhang, Yongting Luo#, Junjie Luo#, Chengying Zhang#. Food groups and urologic cancers risk: A systematic review and meta-analysis of prospective studies. Frontiers in Nutrition. 2023 May 17;10:1154996.
• Lin Zhu, Peng An, Wenting Zhao, Yi Xia, Jingyi Qi#, Junjie Luo#, Yongting Luo#. Low zinc alleviates the progression of thoracic aortic dissection by inhibiting inflammation. Nutrients. 2023 Mar 28;15(7):1640.
• Zhe Wang, Dekui Jin, Shuaishuai Zhou, Niujing Dong, Yuting Ji, Peng An, Jiaping Wang#, Yongting Luo#, Junjie Luo#. Regulatory role of copper metabolism and cuproptosis in human cancers. Frontiers in Oncology. 2023 Mar 23;13:1123420Yi Xia, Xu Zhang, Peng An, Junjie Luo#, Yongting Luo#. Mitochondrial Homeostasis in VSMCs as a Central Hub in Vascular Remodeling. Int J Mol Sci. 2023 Accepted.
• Yanan Sun, Fazheng Ren, Yongting Luo#, Yixuan Li#. mTORC2: multifaceted regulator of autophagy. Cell Communication and Signaling. 2023 Jan 5;21(1):4.
• Xinlu Guo, Junjie Luo, Jingyi Qi, Xiya Zhao, Peng An, Yongting Luo#, Guisheng Wang#. The Role and Mechanism of Polysaccharides in Anti-aging. Nutrients. 2022 Dec 15;14(24):5330.
• Shuaishuai Zhou, Teng Xu, Xu Zhang, Junjie Luo#, Peng An#, Yongting Luo#. Effect of casein hydrolysate on cardiovascular risk factors: a systematic review and meta-analysis of randomized controlled trials. Nutrients. 2022 Oct 9;14(19):4207.
• Yuting Ji, Dekui Jin, Jingyi Qi, Xuan Wang, Chengying Zhang, Peng An, Yongting Luo#, Junjie Luo#. Fucoidan protects against doxorubicin-induced cardiotoxicity by reducing oxidative stress and preventing mitochondrial function injury. Int J Mol Sci. 2022 Sep 14;23(18):10685.
• Linlin Zhang, Jingyi Qi, Xu Zhang, Xiya Zhao, Peng An#, Yongting Luo#, Junjie Luo#. The Regulatory Roles of Mitochondrial Calcium and the Mitochondrial Calcium Uniporter in Tumor Cells. Int J Mol Sci. 2022 Jun 15;23(12):6667.
• Xuan Wang, Yuting Ji, Dekui Jin, Jingyi Qi, Xuening Hou, Wenting Zhao, Shuaishuai Zhou, Chengying Zhang, Yongting Luo#, Peng An#, Junjie Luo#. Natural polysaccharide β-glucan protects against doxorubicin-induced cardiotoxicity by suppressing oxidative stress. Nutrients. 2022 Feb 21;14(4):906.
• Xiya Zhao, Xu Zhang, Teng Xu, Junjie Luo#, Yongting Luo#, Peng An#. Comparative effects between oral lactoferrin and ferrous sulfate supplementation on iron-deficiency anemia: a comprehensive review and meta-analysis of clinical trials. Nutrients. 2022 Jan 27;14(3):543.
• Peng An, Wenyi Xu, Junjie Luo#, Yongting Luo#. Expanding mTOR complex 2 signaling-emerging regulators and new connections. Frontiers in Cell and Developmental Biology. 2021 Jul 30;9:713806.
• Xuan Wang, Peng An, Zhenglong Gu, Yongting Luo#, Junjie Luo#. Mitochondrial metal ion transport in cell metabolism and disease, Int J Mol Sci. 2021 Jul 14;22(14):7525.
• Yongting Luo#, Wenyi Xu, Guannan Li, Wei Cui#. Weighing in on mTOR complex 2 signaling: the expanding role in cell metabolism. Oxidative Medicine and Cellular Longevity. 2018, Article ID 7838647.
• Xing S*, Luo Y*, Liu Z, Bu P, Duan H, Liu D, Wang P, Yang J, Song L, Feng J, Yang D, Qin Z, Yan X#. Targeting endothelial CD146 attenuates colitis and prevents colitis associated carcinogenesis. Am J Pathol. 2014. 184(5):1604-16. (CME Program).
• Qian YN*, Luo YT*, Duan HX, Feng LQ, Bi Q, Wang YJ, Yan XY#. Adhesion Molecule CD146 and its Soluble Form Correlate Well with Carotid Atherosclerosis and Plaque Instability. CNS Neurosci Ther., 2014. 20(5):438-45.
• Duan H*, Xing S*, Luo Y*, Feng L, Gramaglia I, Zhang Y, Lu D, Zeng Q, Fan K, Feng J, Yang D, Qin Z, Couraud PO, Romero IA, Weksler B, Yan X#. Targeting endothelial CD146 attenuates neuroinflammation by limiting lymphocyte extravasation to the CNS. Sci Rep. 2013;3:1687.
• Duan H*, Luo Y*, Hao H*, Feng L*, Zhang Y, Lu D, Xing S, Feng J, Yang D, Song L, Yan X#. Soluble CD146 in cerebrospinal fluid of active multiple sclerosis. Neuroscience. 2013;235:16-26.
• Luo Y*, Zheng C*, Zhang J, Lu D, Zhuang J, Xing S, Feng J, Yang D, Yan X#. Recognition of CD146 as an ERM-binding protein offers novel mechanisms for melanoma cell migration. Oncogene. 2012;31(3):306-21.
• Luo Y, Xu X, Liu J, Li J, Sun Y, Liu Z, Liu J, Van Damme E, Balzarini J, Bao J#. A novel mannose-binding tuber lectin from Typhonium divaricatum (L.) Decne (family Araceae) with antiviral activity against HSV-II and anti-proliferative effect on human cancer cell lines. BMB reports. 2007; 31;40:358-67.
• Wenyi Xu, Yongting Luo #, Wei Cui#. CD146-Rictor interaction reveals a pathway linking mTORC2 activation with extracellular stimuli. Molecular Cancer Research. 2020; 18:10:39.
• Jingjing He, Fangyan Chen, Sitong Wan, Yongting Luo, Junjie Luo, Shuli He, Daizhan Zhou, Peng An, Ping Zeng. Association of serum antioxidant minerals and type 2 diabetes mellitus in Chinese urban residents. Antioxidants. 2022. Accepted.
• Yu Liu, Yuejia Huang, Chong Xu, Peng An, Yongting Luo, Lei Jiao, Junjie Luo, and Yongzhi Li. Mitochondrial Dysfunction and Therapeutic Perspectives in Cardiovascular Diseases. Int J Mol Sci. 2022 Dec 16;23(24):16053.
• Peng An, Sitong Wan, Yongting Luo, Junjie Luo, Xu Zhang, Shuaishuai Zhou, Teng Xu, Jingjing He, Jeffrey Mechanick, Wen-Chih Wu, Fazheng Ren, Simin Liu. Antioxidant Micronutrient Supplementation to Reduce Cardiovascular Disease Risk: An Evidence Map of Randomized Controlled Trials. Journal of the american college of cardiology. 2022 Dec 13;80(24):2269-2285.
• Wu Z, Liu J, Chen G, Du J, Cai H, Chen X, Ye G, Luo Y, Luo Y, Zhang L, Duan H, Liu Z, Yang S, Sun H, Cui Y, Sun L, Zhang H, Shi G, Wei T, Liu P, Yan X, Feng J, Bu P. CD146 is a Novel ANGPTL2 Receptor that Promotes Obesity by Manipulating Lipid Metabolism and Energy Expenditure. Advanced Science (Weinh). 2021 Jan 27;8(6):2004032.
• Jiuzhi Xu, Yang Tang, Xiaole Sheng, Yuhua Tian, Min Deng, Sujuan Du, Cong Lv, Yongli Song, Pengbo Lou, Yongting Luo, Yuan Li, Bing Zhang, Yanmei Chen, Zhanju Liu, Yingzi Cong, Maksim V. Plikus, Qingyong Meng, Zhaocai Zhou, Zhengquan Yu. Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling. EMBO J. 2020 Mar 4:e103255.
• Yan H, Zhang C, Wang Z, Tu T, Duan H, Luo Y, Feng J, Liu F, Yan X#. CD146 is required for VEGF-C-induced lymphatic sprouting during lymphangiogenesis. Sci Rep. 2017 Aug 7;7(1):7442.
• Tu T, Zhang C, Yan H, Luo Y, Kong R, Wen P, Ye Z, Chen J, Feng J, Liu F, Wu JY, Yan X#. CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development, Cell Research, 2015,25(3):275-87.
• Zeng Q, Wu Z, Duan H, Jiang X, Tu T, Lu D, Luo Y, Wang P, Song L, Feng J, Yang D, Yan X#. Impaired tumor angiogenesis and VEGF-induced pathway in endothelial CD146 knockout mice. Protein & Cell, 2014, 5(6):445-56.
• Zhuang J, Cheng T, Gao L, Luo Y, Ren Q, Lu D, Tang F, Ren X, Yang D, Feng J, Zhu J, Yan X#. Silica coating magnetic nanoparticle-based silver enhancement immunoassay for rapid electrical detection of ricin toxin. Toxicon. 2010;55(1):145-52.
• Qian Y, Lin J, Duan H, Luo Y, Feng L.#, Association between serum soluble CD146 level and plaque vulnerability in carotid atherosclerosis, National Medical Journal of China. 2014 Nov;94(43):3392-6.
• Qian Y, Feng L, Bi Q, Duan H, Luo Y, Wang Y.#, A correlation study of adhesion molecule CD146 and the vulnerability of carotid atherosclerotic plaque, Chinese Journal of Internal Medicine. 2014 Aug;53(8):631-4.
• Duan P, Cai F, Luo Y, Chen Y, Zou S.#, Long-term chemiluminescence signal is produced in the course of luminol oxidation catalyzed by enhancer-independent peroxidase purified from Jatropha curcas leaves, Luminescence. 2014. doi: 10.1002/bio.2825.
• Tu T, Gao Q, Luo Y, Chen J, Lu D, Yan X#. CD146 Deletion in the Nervous System Impairs Appetite, Locomotor Activity and Spatial Learning in Mice. PLoS ONE. 2013, 8(9): 74124.
• Wang P, Luo Y, Duan H, Xing S, Zhang J, Lu D, Feng J, Yang D, Song L, Yan X#. MicroRNA-329 suppresses angiogenesis by targeting CD146. Mol Cell Biol. 2013, 33(18):3689-99.
• Jiang T, Zhuang J, Duan H, Luo Y, Zeng Q, Fan K, Yan H, Lu D, Ye Z, Hao J, Feng J, Yang D, Yan X#. CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis. Blood. 2012;120(11):2330-9.
• Zeng Q, Li W, Lu D, Wu Z, Duan H, Luo Y, Feng J, Yang D, Fu L, Yan X#. CD146, an epithelial-mesenchymal transition inducer, is associated with triple-negative breast cancer. Proc Natl Acad Sci U S A. 2012;109(4):1127-32.
• Zhuang J, Jiang T, Lu D, Luo Y, Zheng C, Feng J, Yang D, Chen C, Yan X#. NADPH oxidase 4 mediates reactive oxygen species induction of CD146 dimerization in VEGF signal transduction. Free Radic Biol Med. 2010;49(2):227-36.
• Xu X, Wu C, Liu C, Luo Y, Li J, Zhao X, Damme EV, Bao J#. Purification and characterization of a mannose-binding lectin from the rhizomes of Aspidistra elatior Blume with antiproliferative activity. Acta Biochim Biophys Sin. 2007 Jul;39:507-19.
• Liu J, Xu X, Liu J, Balzarini J, Luo Y, Kong Y, Li J, Chen F, Van Damme E, Bao J#. A novel tetrameric lectin from Lycoris aurea with four mannose binding sites per monomer. Acta Biochim Pol. 2007;54:159-66.
• Xu X, Luo Y, Liu C, Yisheng Sun, Bao J#. The structure and bioactivity of monocot mannose-binding lectin, Nat Prod Res Dev., 2007,19:529-534.

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