Prof. Kanno is a neurosurgeon specialized in central nervous system tumor surgery and researches of hereditary brain tumor disease and neuronal regeneration with stem cells. At present he is engaged in professor of neurosurgery at International University of Health and Welfare School of Medicine in Japan. The research on hereditary brain tumor disease, in particular von Hippel-Lindau disease (VHL), has started since 1993, and the research on neural regeneration with stem cells has started since 1998. In 1994 he found that VHL gene is a causative gene of sporadic hemangioblastoma, and in 2000 he found that the von Hippel-Lindau disease gene plays an important role in neuronal differentiation of neural stem cells, and he is plugging away at the study on neuronal regeneration with stem cells. Recently, he reported BC-box motif peptide mediated neuronal differentiation in 2018.

• Von Hipple Lindau Disease & Gene
• Molecular Genetics
• Neuro-regenerative Medicine
• Mesenchymal Stem Cells
• Human Evolution
• Molecular Signaling Pathway
• Neurosurgery
• COVID-19

• Kanno H, Kuwabara T, Yasumitsu H, and Umeda M. Transforming growth factors in urine from patients with primary brain tumors. J Neurosurg 68: 775-780, 1988.
• Kanno H, Kuwabara T, Shinonaga M, Chang CC, Tanaka Y, Sugio Y, MoritaH, Yasumitsu H, Umeda M, and Nagashima Y. Establishiment of a human glioma cell line bearing a homogeneoulystaining chromosomal region and releasing α-and β-type transforminggrowth factors. Acta Neuropathologica 79: 30-36, 1989.
• Kanno H, Chiba Y, Kyuma Y, Hayashi A, Hiroyuki A, Takada H, Kim I, Yamamoto I. Urinary epidermal growth factor in patients with gliomas:significance of the factor as a glial tumor marker.　J Neurosurg 79: 408-413,1993.
• Tokoro K, Chiba Y, Abe H, Tanaka A, Yamataki A, Kanno H. Importance of anti- siphon devices in the treatment of pediatric hydrocephalus.Child's Nervous System 10; 236-238.,1994.
• 5. Kanno H, Kondo K, Ito S, Yamamoto I, Fujii S, Trigoe S, Sakai N, Hosaka M, Shuin T, Yao M. Somatic mutations of the von Hippel-Lindau tumor suppressor gene in sporadic central nervous system hemangioblastomas.　Cancer Res 54:4845-　4847,1994
• 6. Ito S, Kanno H, Kondo K, Shuin T, Yao M, Hosaka M, Fujii S, Yamamoto I.　　Mutations and loss of heterozygosity of von Hippel-Lindau tumor suppreesor gene in sporadic central nervous system hemangioblastomas. Brain Tumor Research and Therapy, pp277-282, Springer-Verlag, Tokyo, 1995.
• Shuin T, Yao M, Kanno H, Clinical Research Group for VHL in Japan: Germline mutations in the von Hippel-Lindau disease (VHL) gene in Japanese VHL. 　　Hum Mol Genet 4: 2233-2237., 1995.
• Kanno H, Shuin T, Kondo K, Ito S, Hosaka M, Torigoe S, Fujii S, Tanaka Y, Yamamoto I, Kim I, Yao M. Molecular genetic diagnosis of von Hippel- Lindau disease. Jpn J Cancer Res 87: 423-428., 1996.
• 9.Kanno H, Shuin T, Kondo K, Yamamoto I, Ito S, Shinonaga M, Yoshida M, Yao M. Somatic mutations of the von Hippel-Lindau tumor suppressor gene and loss of heterozygosityon chromosime 3p in human glial tumors. Cancer Res 57:1035-1038., 1997
• Yamamoto I, Kanno H, Fujii S. Indication for carotid endarterectomy Neurol Med Chir Suppl (Tokyo) 38: 275-278., 1998.
• Kanno H, Hattori S, Sato H, Murata H, Huang FH, Hayashi A, Suzuki N, Yamamoto I, Kawamoto S, Minami M, Miyatake S, Shuin T, Kaplitt MG. Experimental gene therapy against subcutaneously implanted glioma with a herpes simplex virus-defective vector expressing interferon-γ. Cancer Gene Therapy 6(2) 147-154., 1999.
• Shuin T, Kondo K, Yoshida M, Kanno H, Yao M. Germline mutations in the on Hippel-Lindau disease gene in Japan; its epidemiology and molecular genetic study. Phacomatosis in Japan, Niimura M(eds.)Monograph on Cancer Research 46: 175-182, Japan scientific societies press, Tokyo, 1999.
• Huang FH, Kanno H, Yamamoto I, Lim Y, Kubota Y. Correlation of clinical features and telomerase activity in human gliomas. J Neurooncol 43: 137-142., 1999.
• Yoshida M, Ashida K, Kondo K, Kobayashi H, Kanno H, Shinohara N, Shitara T, Kishida T, Kawakami S, Baba I, Yamamoto I, Hosaka M, Shuin T, Yao M.Germ-line mutation analysis in patients with von Hippel-Lindau disease in Japan:an extented study of 77 families. Jpn J Cancer Res 91: 204-212., 2000.
• Sato H, Hattori S, Kawamoto S, Kudoh I, Hayashi A, Yamamoto I, Yoshinari M, Minami M, Kanno H: In vivo gene gun-mediated DNA delivery into rodent brain tissue. Biochem Biophys Res Comun 270(1): 163-170., 2000
• Kanno H, Saljooque F, Yamamoto I, Hattori S, Yao M, Shuin T, U H-S. Role of the von Hippel-Lindau tumor suppressor protein during neuronal differentiation. Cancer Res 60: 2820-2824., 2000.
• Chang CC, Kanno H, Yamamoto I, Kuwana N.　Cerebrovascular reactivity to acetazolamide in alert patients with cerebral infarction: usefulness of first-pass radionuclide angiography using 99m Tc-HMPAO in monitoring cerebral haemodynamics. Nucl Med Commun 22:1119- 1122., 2001
• Inayama Y, Nishio Y, Ishii M, Mita K, Motono N, Kawano N, Nakatani Y, Kanno H, Hara M. Crush and imprint cytology of subependymoma. Acta Cytol 45(4):636-640, 2001.
• Murata H, Tajima N, Nagashima Y, Yao M, Baba M, Goto M, Kawamoto S, Yamamoto I, Okuda K, Kanno H. Von Hippel-Lindau tumor suppressor protein transforms human neuroblastoma cells into functional neuron-like cells. Cancer Res. 62(23):7004-7011, 2002.
• Chang CC, Kuwana N, Ito S, Yokoyama T, Kanno H, Yamamoto I. Cerebral haemodynamics in patients with hydrocephalus after subarachnoid haemorrhage due to ruptured aneurysm. Eur J Nucl Med Imaging. 30(1):123-126., 2003.
• Kanno H, Yamamoto I, Yoshida M, Kitamura H.Meningioma showing VHL gene inactivation in a patient with von Hippel-Lindau disease. Neurology 2003; 60: 1197- 1199., 2003.
• Yamada H, Dezawa M, Shimazu S, Baba M, Sawada H, Kuroiwa Y, Yamamoto I, Kanno H. Transfer of the von Hippel-Lindau tumor suppressor gene to neuronal progenitorcels in treatment for Parkinson’s disease.Ann Neurol 54(3): 352-359, 2003
• Yamamoto I, Gondo G, Kanno H, Hashimoto M: Nonneoplastic intra-medullary lesios. Neurosurgery Quarterly 13(3): 186-197, 2003.
• Shiraishi H, Chang CC, Kanno H, Yamamoto I. The relationship between cerebral blood flow and cognitive function in patients with brain insult of various etiology. J Clin Neurosi.11(2): 138-141., 2004.
• Murakami K, Kanno H, Yamamoto I, Saito T: Lavendustin A enhances axon elongatin in VHL-gene transferred neural stem cells, NeuroReport 15(4) : 611-614, 2004
• Dezawa M, Kanno H, Hoshino M, Cho H, Matsumoto N, Itokazu Y, Tajima N, Yamada H, Sawada H, Ishikawa H, Mimura T, Kitada M, Suzuki Y, Ide C. Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantaion. J Clin Invest. 113(12):1701-10, 2004.
• Kato K, Nakatani Y, Kanno H, Inayama Y, Ijiri R, Nagahara N, Miyake T, Tanaka M, Ito Y, Aida N, Tachibana K, Sekido K, Tanaka Y.: Possible linkage between specific histological structures and aberrant reactivation of the Wnt pathway in adamantinomatous craniopharyngioma. J Pathol. 203(3):814-21, 2004.
• Mimura T, Dezawa M, Kanno H, Sawada H, Yamamoto I: Peripheral nerve regeneration by transplantation of bone marrow stromal cell-derived Schwann cells in adult rats. J Neurosurg. 101(5):806-12, 2004.
• Ito S, Sekido K, Kanno H, Sato H, Tanaka M, Yamaguchi K, Isao Y. Phenotypic diversity in patients with craniosynostoses unrelated to Apert syndrome: The role of fibroblast growth factor receptor gene mutations. J Neurosurg :Pediactircs. 102: 23- 30, 2005.
• Kanno H, Ozawa Y, Sakata K, Sato H, Tanabe Y, Shimizu N, Yamamoto I. Intraoperativepower Doppler ultrasonography with a contrast-enhancing agent for intracranial tumors. J Neurosurg. 102(2):295- 301, 2005
• Tanaka Y, Kanno H, Dezawa M, Mimura T, Kubo A, Yamamoto I: The role of von Hippel-Lindau protein in the differentiation of neural progenitor cells under normoxic and anoxic conditions. Neurosci Lett.383(1-2):28-32, 2005
• Mimura T, Dezawa M, Kanno H, Yamamoto I. Behavioral and histological evaluation of a focal cerebral infarction rat model transplanted with neurons inducedfrom bone marrow stromal cells. J Neuropathol Exp Neurol. 64(12):1108- 1117, 2005.
• Tajima N, Schonherr K, Niedling S, Kaatz M, Kanno H, Schonherr R, Heinemann SH. Ca2+-activated K+ channels in human melanoma cells are up-regulated by hypoxia involving hypoxia-inducible factor-1alpha and the von Hippel-Lindau protein. J Physiol. 571(Pt 2): 349-359. 2006
• Hattori K, Teranishi J, Stolle C, Yoshida M, Kondo K, Kishida T, Kanno H, Baba M, Kubota Y, Yao M. Detection of germline deletions using real-time quantitative polymerase chain reaction in Japanese patients with von Hippel-Lindau disease. Cancer Sci. 97(5):400-405., 2006.
• Ono A, Kanno H, Hayashi A, Nishimura S, Kyuma Y, Sato H, Ito S, Shimizu N, Chang CC, Gondo G, Yamamoto I, Sasaki T, Tanaka M. Collagen gel matrix assay as an in vitro chemosensitivity test for malignant astrocytic tumors. Int J Clin Oncol. 12(2):125-130.,2007.
• Higashida T, Kanno H, Nakano M, Funakoshi K, Yamamoto I: Expression of hypoxia-inducible angiogenic proteins (HIF-1α, VEGF, Ets-1) and plaque hemorrhage in human carotid atherosclerosis. J Neuosurgery 109:83–91, 2008.
• Kanno H, Nakano S, Kubo A, Mimura T, Tajima N, Sugimoto N: Neuronal differentiation of neural progenitor cells by intracellular delivery of synthetic oligopeptide derived from von Hippel-Lindau protein. Protein Peptide Lett 16(11) : 1291-1296, 2009.
• Kanno H, Yamamoto I, Nishikawa R, Matsutani M, Wakabayashi T, Yoshida J, Shitara N, Yamasaki I, Shuin T, and Clinical VHL Research Group in Japan. Spinal cord hemangioblastomas in von Hippel–Lindau disease. Spinal Cord 47(6):447-452., 2009.
• Kubo A, Yoshida T, Kobayashi N, Yokoyama T, Mimura T, Nishiguchi T, Higashida T, Yamamoto I, Kanno H. Efficient generation of dopamine neuron-like cells from skin-derived precursors with a synthetic peptide derived from von Hippel-Lindau protein.Stem Cells Dev. 18 (10): 1523-1532, 2009.
• Maeda K; Kanno H; Yamazaki Y; Kubo A; Sato F; Yamaguchi Y; Saito T: Transplantation of Von Hippel-Lindau peptide delivered neural stem cells promotes recovery in the injured rat spinal cord. Neuroreport. 20(17):1559-1563, 2009.
• Yamazaki Y, Kanno H, Maeda K, Yoshida T, Kobayashi N, Kubo A, Yamaguchi Y, Saito T. Engrafted VHL peptide-delivered bone marrow stromal cells promote spinal cord repair in rats. Neuroreport. 21:287-292, 2010.
• Ito R, Kanno H, Takahashi A, Matsumoto, Kobayashi N, Yoshida T, Saito T. Efficient growth inhibition of human osteosarcoma cells using a peptide derived from the MDM-2-binding site of p53. Protein Peptide Lett 17(5): 610-615, 2010.
• Higashida, T, Jitsuki S, Kubo A, Mitsushima D, Kamiya Y, Kanno H, Skin-derived precursors differentiate into dopaminergic neuronal cells in the brains of Parkinson's disease model rats. J Neurosurg 113(3):648-55, 2010.
• Murakami A, Oshiro H, Kanzaki S, Yamaguchi A, Yamanaka S, Furuya M, Miura S, Kanno H, Nagashima Y, Aoki I, Nagahama K: A novel method for isolating podocytes using magnetic activated cell sorting. Nephrol Dial Transplant. 25(12):3884-3890, 2010.
• Yamada S, Kanno H, Kawahara N. Trans-membrane peptide therapy for malignant glioma by use of a peptide derived from the MDM2 binding site of p53. J Neurooncol. 109(1):7-14.2012.
• Tateishi K, Tateishi U, Sato M, Yamanaka S, Kanno H, Murata H, Inoue T, Kawahara N. Application of 62Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) PET Imaging to Predict Highly Malignant Tumor Grades and Hypoxia-Inducible Factor-1α Expression in Patients with Glioma. AJNR Am J Neuroradiol. 34(1):92-9. 2013
• Kanno H, Kuratsu J, Nishikawa R, Mishima K, Natsume A, Wakabayashi T, Houkin K, Terasaka S, Shuin T: Clinical features of patients bearing central nervous system hemangioblastoma in von Hippel-Lindau disease. Acta Neurochirurgica 155(1):1-7, 2013
• Kanno H, Sato H, Yokoyama TA, Yoshizumi T, Yamada S. The VHL tumor suppressor protein regulates tumorigenicity of U87-derived glioma stem-like cells by inhibiting the JAK/STAT signaling pathway. Int J Oncol. ;42(3):881-886., 2013
• Kanno H, Kubo A, Yoshizumi T, Mikami T, Maegawa. Isolation of multipotent nestin-expressing stem cells derived from the epidermis of elderly humans and TAT-VHL peptide-mediated neuronal differentiation of these cells. J.Int J Mol Sci. 14(5):9604-9617, 2013
• Kanno H. Regenerative therapy for neuronal diseases with transplantation of somatic stem cells. World J Stem Cells. 5(4):163-171, 2013.
• Kanno H. Advantage of intraoperative power doppler ultrasonography for intracranial tumors. Tumors of the Central Neurvors System. Volume 13: Types of Tumors, Diagnosis, Ultrasonography, Surgery, Brain Metastasis, and General CNS Diseases. Edited by Hayat MA, pp137-147, Springer, 2014
• Kanno H, Nakanowatari S: Treatment for Glioblastoma with Carboplatin, Oral Etoposide and Interferon β (CEI): A Phase II Trial. JMS Neurosurg Spine. 2(3), 1027, 2014
• Kanno H. An update on von Hippel-Lindau disease and its translational research. J Transl Med Edidemiol, 2(1): 1012. 2014
• Kanno H, Kobayashi N, Nakanowatari S: Pathological and clinical features and management of central nervous system hemangioblastomas in von hippel-lindau disease. JKCVHL (Journal of Kidney Cancer and VHL) 1(4):46-55, 2014.
• Kanno H, Higashida T, Miyake S, Kobayashi N and Nakanowatari：Role of Vascular Endothelial Growth Factor in Atherosclerotic Carotid Plaques. Austin Journal of Cerebrovascular Disease & Stroke 1(6): 1030., 2014
• Suenaga J, Tateishi K, Takase H, Kanno H and Kawahara N. Oculomotor Nerve Schwannoma Presenting as an Entirely Cystic Homogeneous Mass on Magnetic Resonance Imaging: Case Report. Austin J Neurosurg.;1(3): 1013., 2014
• Kanno H, Sasame J, Miyake S, Nakanowatari S, Numata A, N, Nagatsuka N2, Fukushige N2, Ito T, Inoue Y. Activities of Daily Living of Patients with Malignant Brain Tumors Assessed By Using Functional Independence Measurement Scoring System. Int J Neurorehabilitation 2: 171. 2015, doi:10.4172/2376-0281.1000171
• Kanno H. Salvage therapy with high-dose cytarabine for primary central nervous system lymphoma. “Primary central nervous system lymphoma (PCNLS): Incidence, management and outcomes” edited by Rruya Yamanaka. Chapter 14. pp167-174. Nova Biomedical, New York, 2016
• Bausch B, Wellner U, Peyre M, Boedeker CC, Hes FJ, Anglani M, de Campos JM, Kanno H, Maher ER, Krauss T, Sansó G, Barontini M, Letizia C, Hader C, Schiavi F, Zanoletti E, Suárez C, Offergeld C, Malinoc A, Zschiedrich S, Glask S, Bobin S, Sterkers O, Tran Ba Huy P, Giraud S, Links T, Eng C, Opocher G, Richard S, Neumann HP; International ELST Consortium. Characterization of endolymphatic sac tumors and von Hippel-Lindau disease in the international ELST registry. Head Neck. Head Neck 38 Suppl 1:E673-679. 2016. doi: 10.1002/hed.24067.
• Kanno H, Steinbach JP. 16: Familial tumor syndoromes–B (von Hippel-Lindau disease). Oxford Textbook of Neuro-Oncology edited by Tracy Batchelor, Ryo Nishikawa, Nancy Tarbell, and Michael Weller. pp187-193. Oxford University Press. September 7 th, 2017.
• Takayanagi S, Mukasa A, Nakatomi H, Kanno H, Kuratsu JI, Nishikawa R, Mishima K, Natsume A, Wakabayashi T, Houkin K, Terasaka S, Yao M, Shinohara N, Shuin T, Saito N. Development of Database and Genomic Medicine for von Hippel-Lindau Disease in Japan. Neurol Med Chir (Tokyo). 2017;57(2):59-65. doi: 10.2176/nmc.ra.2016-0206.
• Kanno H, Xu Y, Miyakawa T, Kubo A, Higashida T, Kobayashi NB, Yoshida T, Tanokura M BC-Box Motif-Mediated Neuronal Differentiation of Somatic Stem Cells..Int J Mol Sci. 2018;19(2). pii: E466. doi: 10.3390/ijms19020466.
• Kanno H, Osano S, Shinonaga M.VHL-Associated Optic Nerve Hemangioblastoma Treated with Stereotactic Radiosurgery.　J Kidney Cancer VHL. 2018;5(2):1-6. doi: 10.15586/jkcvhl.2018.104. eCollection 2018
• Kanno H, Yoshizumi T, Nakazato N, Shinonaga M: Predictors of response to the epidural blood patch in patients with spinal leakage of cerebrospinal fluid. J Clin Neurol 2020;16(1):1-8
• Kanno　H, Yoshizumi T, Nakahara K, Shinonaga M, U H-S. CRISPR-mediated genome editing in the field of surgery: review. Clin in Surg. 2020; 5: 2851.
• Kanno H, Yoshizumi T, Shinonaga M, Kubo A, Murata H, Yao M.　Role of VHL-JAK-STAT signaling pathway in central nervous system hemangioblastoma associated with von Hippel-Lindau disease. J Neurooncol. 2020;　148(1):29-38.
• Yoshizumi T, Kubo A, Murata H, Shinonaga M, Kanno H.　BC-box motif in SOCS6 induces differentiation of epidermal stem cells into GABAnergic neurons. Int J Mol Sci. 2020;21(14):4947.
• Yoshizumi T, Kanno H, Murata H, Shinonaga M. Efficacy of supraclavicular scalenotomy followed by external neurolysis without rib resection for post-traumatic neurogenic thoracic outlet syndrome. Spine ;46(11):E632-E638. 2021
• Kanno H, Yoshizumi T, Nakazato N, Shinonaga M. Predictors of the Response to an Epidural Blood Patch in Patients with Spinal Leakage of Cerebrospinal Fluid. J Clin Neurol. 2020 ;16(1):1-8
• Kanno H, Kanetsuna Y, Shinonaga M. Anaplastic myxopapillary ependymoma: A case report and review of literature . World J Clin Oncol 12　(11):1072-1082. 2021.
• Kanno H, Matsumoto S, Yoshizumi T, Nakahara K, Kubo A, Murata H, Shuin T, U HS. Role of SOCS and VHL Proteins in Neuronal Differentiation and Development. Int J Mol Sci. 24(4):3880.2023
• Kanno H, Matsumoto S, Yoshizumi T, Nakahara K, Shinonaga M, Kubo A, Fujii S, Ishizuka Y, Tanaka M, Ichihashi M, Murata H. SOCS7-Derived BC-Box Motif Peptide Mediated Cholinergic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells. Int J Mol Sci. 2023;24(3):2786
• Miyazaki K, Kanno H, Yamada S, Sagehashi Y, Matsumoto S, Takahashi S, Kim Y, Namiki K, Fujii S: Clinical features and treatment of patients infected with SARS-CoV-2 Omicron Variant while hospitalized due to stroke: A single center study in Japan. Cureus. 16: e54760.2024.
• Kanno H, Nakahara K, Miyamoto M, Yamada S,　Kim Y, Fujii S, Hidetoshi M, Ishizuka Y, Tanaka M,　Ichihashi M: Intravenous transplantation of autologous adipose-derived mesenchymal stem cells for chronic stage ischemic stroke: a case report of rapid and dramatic improvement and review of the literature. Cellular Therapy and Transplantation. 13: 44-52, 2024.
• Kanno H, Nakahara K, Yamada S, Fujii S, Murata H, Yamamoto T, Hasumi H, Yao M. Relationship between ZHX2 expression and VHL gene alteration in VHL-associated and sporadic hemangioblastomas of the central nervous system. J Kidney Cancer VHL. 11: 39-47, 2024
• Shiraishi T, Eguchi H, Kanno H. Mechanical Vibration Regulates Differentiation and Proliferation of Neural Stem Cells ASME J of Medical Diagnostics. 2025, 8(3): 031012 (8 pages).

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• https://orcid.org/0000-0002-4335-3899
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