Editor Profile
Ms. Martina Rella
PhD Student
Present
University of Bari Aldo Moro
Bari
Italy
I am a PhD candidate in Transplantation of Tissues and Organs and Cellular Therapies at the University of Bari Aldo Moro, working at the Biomedical Research Laboratory in Endocrinology and Metabolic Diseases. My research focuses on pancreatic β-cell biology and the molecular mechanisms underlying β-cell dysfunction in type 2 diabetes.
My work investigates the role of the myokine irisin (FNDC5) in regulating insulin secretion, β-cell survival, and metabolic signaling pathways.
I combine in vitro and in vivo models, including human pancreatic islets and murine models of diabetes, with advanced proteomics approaches to identify novel ligand–receptor interactions and signaling mechanisms.
My research integrates molecular biology, quantitative proteomics, and advanced imaging techniques to explore inter-organ communication in metabolic diseases.
- Pancreatic β-cell biology and mechanisms regulating insulin secretion
- β-cell dysfunction, dedifferentiation and survival in type 2 diabetes
- Myokine signaling in metabolic tissues, with focus on irisin/FNDC5
- Glucolipotoxicity and metabolic stress in pancreatic islets
- In vivo models of diabetes (HFD/STZ models, genetic mouse models)
- Human pancreatic islets and translational endocrinology
- Quantitative proteomics and bioinformatics for receptor discovery
- Adipose Tissue Secretion Pattern Influences β-Cell Wellness in the Transition from Obesity to Type 2 Diabetes. Biondi, G.; Marrano, N.; Borrelli, A.; Rella, M.; Palma, G.; Calderoni, I.; Siciliano, E.; Lops, P.; Giorgino, F.; Natalicchio, A. Int. J. Mol. Sci. 2022, 23, 5522. https:// doi.org/10.3390/ijms23105522. International Journal of Molecular Science 2022.
- The p66Shc protein mediates insulin resistance and secretory dysfunction in pancreatic beta-cells under lipotoxic conditions. Biondi, G.; Marrano, N.; Dipaola, L.; Borrelli, A.; Rella, M.; D’Oria, R.; Genchi, V. A.; Caccioppoli, C.; Porreca, I.; Cignarelli, A.; Perrini, S.; Marchetti, P.; Vincenti, L.; Laviola, L.; Giorgino, F.; Natalicchio, A. https://doi.org/10.2337/db21-1066. Diabetes 2022. Accepted.
- Irisin administration restores beta-cell functional mass in a mouse model of type 2 diabetes. Marrano, N.; Biondi, G.; Borrelli, A.; Rella, M.; Roberto, L.; Cignarelli, A.; Perrini, S.; Laviola, L.; Giorgino, F.; Natalicchio, A. Oral Presentation, 58th EASD Annual Meeting, September 19-23, 2022. Stockholm & Online. Diabetologia. Accepted.
- I farmaci incretinici contrastano il danno indotto da pasireotide in beta-cellule pancreatiche. Biondi, G.; Marrano, N.; Borrelli, A.; Rella, M; Vincenti, L; Cignarelli, A.; Perrini, S.; Laviola, L.; Giorgino, F.; Natalicchio, A. Poster non discusso (P77), 29th congresso SIE, Rimini 26-29 ottobre 2022. Accettato.
- L’irisina ripristina la massa funzionale beta-cellulare e l’omeostasi glicemica in topi diabetici. Borrelli, A.; Marrano, N.; Biondi, G.; Rella, M.; Roberto, L.; Cignarelli, A.; Perrini, S.; Laviola, L.; Giorgino, F.; Natalicchio, A. Comunicazione orale (CO63), 29th congresso SIE, Rimini 26-29 ottobre 2022. Accettato.
- Effetto delle terapie anti-diabete sulla secrezione di irisina in pazienti con diabete di tipo 2. Marrano, N.; Biondi, G.; Le Grazie, G.; Montedoro, A.; Di Gioia, L.; Guarini, F.; Borrelli, A.; Rella, M.; Cignarelli, A.; Perrini, S.; Laviola, L.; Giorgino, F.; Natalicchio, A. Poster discussion (PD57), 29th congresso SIE, Rimini 26-29 ottobre 2022. Accettato.
