Dr. Zhekai (Kevin) Hu, DDS, MDS, PhD, is currently a Dental Resident at the Eastman Institute for Oral Health, University of Rochester Medical Center, USA. He received his Master of Dental Surgery in Orthodontics from Shanghai Jiao Tong University and completed his PhD in Orthodontics at The University of Hong Kong with the HKU Presidential PhD Award. His academic and clinical interests focus on orthodontics, craniofacial imaging, oral inflammation, biomaterials, and translational dental research. Dr. Hu has authored multiple peer-reviewed publications and currently serves as an editorial board member, guest editor, and reviewer for numerous international journals.

• Orthodontics and Craniofacial Imaging
• CBCT and 3D Cephalometric Analysis
• Periodontology and Oral Inflammation
• Regenerative Dentistry and Biomaterials
• Implant Dentistry
• Translational Dental Research

• Xia Y, Cheng T, Zhang C, Zhou M, Hu Z, Kang F, Liao C. Human Bone Marrow Mesenchymal Stem Cell-derived Extracellular Vesicles Restore Th17/Treg Homeostasis in Periodontitis via miR-1246. FASEB Journal. 2023 (SCI JCR Q1, IF: 4.8)
• Li Y, Bi D, Hu Z, Yang Y, Liu Y, Leung WK. Hydrogel-Forming Microneedles with Applications in Oral Diseases Management. Materials. 2023(SCI JCR Q3, IF: 3.4)
• Hu Z, Li Y, Yuan W, Jin L, Leung WK, Zhang C, Yang Y. N6-methyladenosine of Socs1 modulates macrophage inflammatory response in different stiffness environments. International Journal of Biological Sciences. 2023. (SCI, JCR Q1, IF:10.75)
• Hu Z, Qiu W, Yu Y, Wu X, Fang F, Zhu X, Tu Q, Van Dyke T. Morgan E, Chen J. Identification and Characterization of a Novel Long Noncoding RNA that Specifically Targets Diabetic Bone Disease. Frontiers in Cell and Developmental Biology. (SCI, JCR Q1, IF:6.684)
• Wu X, Sun Y, Cui R, Qiu W, Zhang J, Hu Z, Bi W, Yang F, Ma D, Dyke T, Tu Q, Yu Y, Chen J. A novel adiponectin receptor agonist (AdipoAI) ameliorates type 2 diabetes-associated periodontitis by enhancing autophagy in osteoclasts. Journal of Periodontal Research, 2022; 00: 1– 11. ( SCI, JCR Q1, IF:4.419)
• Wang X, Sun H, Hu Z, Mei P, Wu Y, Zhu M. NUTM2A-AS1 silencing alleviates LPS-induced apoptosis and inflammation in dental pulp cells through targeting let-7c-5p/HMGB1 axis. International Immunopharmacology, 2021 Jul;96:107497. (SCI, JCR Q2, IF:4.932)
• Qiu, W., Wu, H., Hu, Z., Wu, X., Tu, M., Fang, F., Zhu, X., Liu, Y., Lian, J., Valverde, P., Van Dyke, T., Steffensen, B., Dong, L. Q., Tu, Q., Zhou, X., & Chen, J. 2021. Identification and characterization of a novel adiponectin receptor agonist adipo anti-inflammation agonist and its anti-inflammatory effects in vitro and in vivo. British journal of pharmacology, 178(2), 280–297. (SCI, JCR Q1, IF:8.74)
• Hu, Z., Sun, H., Wu, Y., Wu, X., Mei, P., Wang, B., Zhu, M. Mouth breathing impairs the development of temporomandibular joint at a very early stage. Oral Diseases, 2020;00:1–11. (Cover Article, SCI, JCR Q1, IF: 3.511)
• Hu, Z., Wang, X., Xia, W., Wang, Z., Zhang, P., Xia, L., Lin, K., Zhu, M.,2019. Nano-Structure Designing Promotion Osseointegration of Hydroxyapatite Coated Ti–6Al–4V Alloy Implants in Diabetic Model. Journal of Biomedical Nanotechnology, 15(8), pp.1701-1713. (SCI, JCR Q2, IF: 4.099)
• Han, Y. #, Li, Y. #, Hu, Z. #, Wang, X., Ren, X., Yu, Y., Li, Y., Li, W. and Sun, Y., 2019. Hydrogen sulfide-mediated resistance against water avoidance stress-induced gastritis by maintenance of gastric microbial homeostasis. MicrobiologyOpen，e951. (SCI, JCR Q3, IF: 3.139)
• Wu, X., Qiu, W., Hu, Z., Lian, J., Liu, Y., Zhu, X., Tu, M., Fang, F., Yu, Y., Valverde, P. and Tu, Q., 2019. An Adiponectin Receptor Agonist Reduces Type 2 Diabetic Periodontitis. Journal of Dental Research, 98(3), pp.313-321. (SCI, JCR Q1, IF: 7.199)
• Kang, W., Wang, T., Hu, Z., Liu, F., Sun, Y. and Ge, S., 2017. Metformin Inhibits Porphyromonas gingivalis Lipopolysaccharide-Influenced Inflammatory Response in Human Gingival Fibroblasts via Regulating Activating Transcription Factor-3 Expression. Journal of Periodontology, 88(10), pp.e169-e178. (SCI, JCR Q1, IF: 6.993)
• Geng, X., Li, W., Chen, Z., Gao, S., Hong, W., Ge, X., Hou, G., Hu, Z., Zhou, Y., Zeng, B., and Li, W., 2017. The bifunctional enzyme SpoT is involved in the clarithromycin tolerance of Helicobacter pylori by upregulating the transporters HP0939, HP1017, HP0497, and HP0471. Antimicrobial Agents and Chemotherapy, 61(5), pp.e02011-16. (SCI, JCR Q1, IF: 5.346)
• Hu, Z., Zhang, Y., Li, Z., Yu, Y., Kang, W., Han, Y., Geng, X., Ge, S., and Sun, Y., 2016. Effect of Helicobacter pylori infection on chronic periodontitis by the change of microecology and inflammation. Oncotarget, 7(41), p.66700. (SCI, JCR Q1, IF: 5.376)
• Kang, W., Hu, Z. and Ge, S., 2016. Healthy and inflamed gingival fibroblasts differ in their inflammatory response to Porphyromonas gingivalis lipopolysaccharide. Inflammation, 39(5), pp.1842-1852. (SCI, JCR Q3, IF: 4.029)

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