WebLog Journal of Clinical Case Reports

Introduction: The use of sedatives in frail older adults represents a significant challenge in clinical and nursing practice due to age-related pharmacokinetic and pharmacodynamic changes that increase susceptibility to adverse drug reactions. Physiological alterations such as reduced hepatic metabolism, decreased renal clearance, altered protein binding, and increased blood-brain barrier permeability enhance drug accumulation and central nervous system sensitivity.…

Background: Severe thrombocytopenia in the postpartum period is a life-threatening condition requiring urgent differentiation between thrombotic thrombocytopenic purpura (TTP), disseminated intravascular coagulation (DIC), and HELLP syndrome. Early recognition significantly impacts survival.

Case Presentation: A 20-year-old previously healthy primiparous woman presented 7 days after spontaneous vaginal delivery with dyspnea, fatigue, abdominal…

Background: Ovarian torsion (OT) is a rare but significant gynaecological emergency that requires prompt diagnosis and intervention to preserve ovarian function. It results from the twisting of the ovary and fallopian tube around the vascular pedicle, leading to ischemia and potential necrosis. In pediatric patients, OT is particularly challenging to diagnose due to its nonspecific clinical presentation, often mimicking other causes of acute abdominal…

Median nerve injuries in pediatric patients represent a significant challenge due to their impact on hand function and fine motor development. This case report presents the rehabilitation outcomes of a seven-year-old child who sustained a traumatic injury involving the flexor pollicislongus and flexor carpi radialis muscles with associated radial artery injury and median nerve lesion. The patient underwent a structured physiotherapy program including neuromuscular electrical stimulation and…

Neonatal hypoganglionosis is a rare congenital dysganglionosis typically presenting in the neonatal period with intestinal obstruction. Initial symptoms may include intermittent massive abdominal distension and non-bilious vomiting. Presentation beyond infancy is common, often subtle and easily missed, while acute appendicitis following inadequate conservative therapy is exceptionally rare. We describe a 3-year-old girl who presented with atypical features of acute appendicitis, posing a…

With age, mutations and damage to DNA accumulate, disrupting the normal functioning of cells, the hormonal and genetic systems, and the body as a whole. The synergy between the hormonal and genetic systems and the body's energetic connection with nature are disrupted. This leads to accelerated aging. As the body ages, cells lose their ability to divide due to the fraying of chromosome ends, which shorten with each division. The lifespan of cells and the body itself is shortened. The future…

The paper deals with a very difficult topic of hearing, which consists in simultaneous reception by the auditory receptor of an unlimited amount of information encoded in a sound wave. The received information is processed in the auditory cell and transmitted to the brain. The signal path must be as short and fast as possible, without the multiple energy transformations described in the traveling wave theory. The molecular mechanism of hearing, described in submolecular theory, refers to the…

Hormonal therapy is the standard treatment for advanced androgen-dependent prostate adenocarcinoma. If tumor regression is not achieved early, the adenocarcinoma inevitably evolves toward androgen independence. This is due to the development of resistance mechanisms and the incomplete tissue-level cessation of androgen deprivation. Current research is focused on combined therapeutic strategies that will increase the effectiveness of androgen deprivation and delay recurrence. Androgen…

Therapy of the interstitial fluid before the destruction of intercellular connections has two interrelated directions, firstly, a decrease in the interstitial fluid (interstitial fluid) and normalization of the tumor microclimate before the intercellular connections are destroyed, and secondly, the destruction of intercellular connections as part of therapy (to increase drug penetration. The interstitial fluid and the surrounding ECM environment come to the fore, and the intercellular…

Translational medicine areas include areas aimed at applying the results of basic research to develop new methods for diagnosing, treating and preventing diseases. The main areas of translational medicine are, firstly, personalized medicine - development of individual approaches to treatment based on the patient’s genetic, molecular and clinical information. Secondly, molecular diagnostics - creation of methods for identifying biomarkers and genetic markers of diseases for early diagnosis…