WebLog Journal of Clinical Case Reports

Vildagliptin, a Dipeptidyl Peptidase-4 (DPP-4) inhibitor widely used in type 2 diabetes mellitus, is generally considered well-tolerated. We report a case of a 62-year-old woman who developed progressive, isolated thrombocytopenia approximately ten months after initiating vildagliptin 50 mg twice daily as an add-on to her existing antidiabetic regimen. Extensive haematological evaluation excluded alternative aetiologies including immune thrombocytopenic purpura, viral infections,…

A single night in a hospital, spent accompanying a child, can reveal a complex interaction between biological rhythms, environmental unfamiliarity, and emotional attachment. This reflective commentary examines the experience of being physically exhausted yet unable to sleep in a hospital environment. Drawing on insights from sleep science, psychology, and ecological thinking, this reflection paper explores how unfamiliar environments trigger vigilance, how parental concern sustains cognitive…

The global research climate has changed as a result of the introduction of Article Processing Charges (APCs) as a primary funding mechanism for open-access publications. Although APCs have facilitated access to and dissemination of scientific knowledge, their abuse has given rise to significant ethical concerns, particularly with regard to authorship credibility and study integrity. The consequences of improperly regulated APC-driven publishing models which encourage unethical writing…

Gitelman Syndrome (GS) is a rare autosomal recessive renal tubulopathy caused by inactivating mutations in the SLC12A3 gene, characterised by hypokalemia, hypomagnesemia, hypocalciuria, and metabolic alkalosis. Hyperthyroidism - most commonly Graves’ disease -independently produces hypokalemia through intracellular potassium shift mediated by upregulated Na+-K+-ATPase activity, a phenomenon termed Thyrotoxic Periodic Paralysis (TPP). When these two conditions coexist, the electrolyte…

Background: Noonan syndrome is an autosomal dominant multisystem disorder characterized by short stature, distinctive facial features, congenital heart defects, and variable developmental delays. While pulmonary valve stenosis is the most common cardiac lesion, Tetralogy of Fallot is rarely reported in Noonan syndrome. To date, there are fewer than 60 documented cases of Noonan syndrome associated with Tetralogy of Fallot in the medical…

Background: Spinal arachnoid cysts are rare, benign cerebrospinal fluid–filled lesions that may cause spinal cord or nerve root compression. They are most frequently located in the thoracic region and typically present with a slow, insidious clinical course.

Case Description: We report the case of a 52-year-old man presenting with a 3-4-year history of progressive back pain and markedly reduced walking distance consistent with neurogenic…

Introduction: The use of sedatives in frail older adults represents a significant challenge in clinical and nursing practice due to age-related pharmacokinetic and pharmacodynamic changes that increase susceptibility to adverse drug reactions. Physiological alterations such as reduced hepatic metabolism, decreased renal clearance, altered protein binding, and increased blood-brain barrier permeability enhance drug accumulation and central nervous system sensitivity.…

Background: Severe thrombocytopenia in the postpartum period is a life-threatening condition requiring urgent differentiation between thrombotic thrombocytopenic purpura (TTP), disseminated intravascular coagulation (DIC), and HELLP syndrome. Early recognition significantly impacts survival.

Case Presentation: A 20-year-old previously healthy primiparous woman presented 7 days after spontaneous vaginal delivery with dyspnea, fatigue, abdominal…

Background: Ovarian torsion (OT) is a rare but significant gynaecological emergency that requires prompt diagnosis and intervention to preserve ovarian function. It results from the twisting of the ovary and fallopian tube around the vascular pedicle, leading to ischemia and potential necrosis. In pediatric patients, OT is particularly challenging to diagnose due to its nonspecific clinical presentation, often mimicking other causes of acute abdominal…

Median nerve injuries in pediatric patients represent a significant challenge due to their impact on hand function and fine motor development. This case report presents the rehabilitation outcomes of a seven-year-old child who sustained a traumatic injury involving the flexor pollicislongus and flexor carpi radialis muscles with associated radial artery injury and median nerve lesion. The patient underwent a structured physiotherapy program including neuromuscular electrical stimulation and…