WebLog Journal of Gastroenterology

Objectives: To synthesise emerging evidence that colorectal motility disorders, traditionally viewed as isolated hindgut conditions, may initiate a progressive, system‑wide sequence of gastrointestinal and extra‑intestinal dysfunction. This review proposes an “ascending cascade” model in which partial functional obstruction of the hindgut triggers upstream effects on the midgut, foregut, biliary‑pancreatic axis, and respiratory and ENT…

Objectives: To re‑examine infantile hypertrophic pyloric stenosis (IHPS) through a contemporary, multidimensional framework that integrates structural, functional, and psycho‑neuro‑endocrine‑immune (PNEI) mechanisms. This review synthesises current evidence on IHPS epidemiology, pathophysiology, and clinical presentation, and evaluates minimally invasive diagnostic and therapeutic approaches. It further explores how emerging insights into gut–brain and neuroimmune regulation…

Objectives: To synthesise current evidence on modified and extended anorectal myomectomy and transanal endosurgical procedures as diagnostic and therapeutic tools in congenital and acquired colorectal motility disordersand to clarify their role alongside manometry, radiology, and histopathology in contemporary clinical practice [1-4].

Design: Narrative review.

Data Sources: Peer-reviewed literature from PubMed,…

Objective: To compare the effectiveness and safety of conservative/medical therapy, Lord’s anal dilatation, lateral internal sphincterotomy, posterior sphincterotomy (including modifications), anorectal myomectomy, and early transanal endosurgical procedures in the management of chronic anal fissure.

Design: Retrospective cohort study.

Setting: Shri M. P. Shah Medical College and the Irwin Group of Tertiary University…

Objective: To assess the risk of colorectal malignancy in CD patients with and without colectomy over time.

Methods: A retrospective cohort study was conducted using the TriNetX Research Network, which includes data from 70 U.S. healthcare organizations. A total of 7,315 CD patients who underwent partial or total colectomy were matched 1:1 to 7,315 patients without surgical intervention. Patients with ulcerative colitis were excluded. CRC…

Background & Aims: The long-term risk of colorectal neoplasia in ulcerative colitis (UC) patients undergoing colectomy remains poorly quantified. This study compared the incidence of colorectal malignancies in UC patients with versus without colectomy across 5-year, 10-year, and 20-year follow-up.

Methods: Using the TriNetX US Collaborative Network, we conducted a propensity score-matched cohort study of 3,767 UC patients with colectomy…

Breast milk, traditionally recognized for its unparalleled nutritional benefits in neonatal development, has emerged as a potential therapeutic agent in adult gastrointestinal disease management. Recent studies suggest that the bioactive components in breast milk—such as immunoglobulins, growth factors, and antimicrobial peptides—may offer significant advantages in treating chronic gastrointestinal disorders, including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and…