WebLog Journal of Stem Cells Research and Therapy

Despite the current advances in the field, articular cartilage defects and osteoarthritis remain a challenge in the clinic due to the fact that mature cartilage lacks blood supply, is poorly cellular and has a weak intrinsic repair response. Although conventional treatments focusing on the symptoms can alleviate pain and surgical methods can restore some function in a few lesions, regeneration of hyaline cartilage with native zonal architecture is rare. Exosomes, or small extracellular…

Previously, we reported that the von Hippel-Lindau (VHL) tumor suppressor gene induces neural stem cell (NSC) differentiation to neurons, and that VHL's involvement in differentiating NSCs or mesenchymal stem cells (MSCs) into neurons is related to the inhibition of the JAK/STAT pathway through the proteasomal degradation of proteins following their ubiquitination by the VHL/ elonginBC/Cul2 complex. However, the relationship between VHL and other pathways and factors around VHL-mediated…