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ARTICLE TYPE : RESEARCH ARTICLE

Published on :   11 Jun 2026, Volume - 2
Journal Title :   WebLog Journal of Analytical and Pharmaceutical Chemistry | WebLog J Anal Pharm Chem | WJAPC
Journal ISSN:   3071-4125
Source URL:   weblog icon https://weblogoa.com/articles/wjapc.2026.f1106
Permanent Identifier (DOI) :   doi icon https://doi.org/10.5281/zenodo.20952706

Quantitative Analysis of Cilazapril and Alacepril in Their Bulk and Pharmaceutical Dosage Form Using 1,10-Phenanthroline

Nashat Abdalaty 1 *
1Medical and Radioactive Research Department, Nuclear Materials Authority, Cairo, Egypt

Abstract

A new, simple and rapid spectrophotometric method with broad linear dynamic range was developed for the quantification of two angiotensin- converting enzyme inhibitors, namely cilazapril and alacepril. The method was based on the oxidation of the two drugs by Fe(III) in presence of 1.10 phenanthroline, the formed tris-(Fe-o-phen) complex in acetate buffer and optimum pH was measured at λmax 510 and 512 nm for cilazapril and alacepril respectively with linear relationship over concentration range from 10-54 µgml-1. The results of the reported method of the analysis suggest that the developed approach is simple, sensitive, accurate and precise.

Keywords: Cilazapril; Alacepril; Spectrophotometry; Oxidation; 1,10-Phenanthroline

Citation

Abdalaty N. Quantitative Analysis of Cilazapril and Alacepril in Their Bulk and Pharmaceutical Dosage Form Using 1,10-Phenanthroline. WebLog J Anal Pharm Chem. wjapc.2026.f1106. https://doi.org/10.5281/zenodo.20952706
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