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ARTICLE TYPE : RESEARCH ARTICLE

Published on :   15 Sep 2025, Volume - 1
Journal Title :   WebLog Journal of Cancer and Clinical Research | WebLog J Cancer Clin Res
Source URL:   weblog iconhttps://weblogoa.com/articles/wjcacr.2025.i1502
Permanent Identifier (DOI) :  doi iconhttps://doi.org/10.5281/zenodo.17214006

Breast Milk-Derived Exosomes as Natural Nanocarriers in Cancer Therapy in Adults

Dr. Rehan Haider 1 *
Dr. Geetha Kumari Das 2
Dr. Zameer Ahmed 3
1Department of Pharmacy, Riggs Pharmaceutical, University of Karachi, Karachi, Pakistan
2GD Pharmaceutical Inc., OPJS University, Rajasthan, India
3Assistant Professor, Department of Pathology, Dow University of Health Sciences (DUHS), Karachi, Pakistan

Abstract

Abstract: Breast milk is a bioactive fluid known for its nutritional value for infants, but recent studies have uncovered its potential beyond early life care. Among its components, breast milk-derived exosomes stand out. These nanoscale extracellular vesicles contain proteins, lipids, and nucleic acids and play an essential role in immune regulation and cellular communication. Given their biocompatibility, stability, and ability to cross biological barriers, these exosomes have gained attention as potential delivery systems for cancer therapy in adults.

Recent studies suggest that breast milk-derived exosomes can transport tumor-suppressive microRNAs, enhance immune response, and serve as carriers for established chemotherapy agents. Their natural membrane structure provides enhanced stability during circulation and lowers the risk of immune rejection compared to synthetic nanocarriers. Additionally, these exosomes hold the promise of reducing the systemic toxicity typically associated with traditional chemotherapy by enabling more precise drug delivery to cancerous tissues. Early investigations into their applications in various cancers, including breast, colorectal, lung, and liver, show promising results regarding efficacy and tolerability.

Despite the potential, there are several hurdles to overcome before clinical use is feasible. These include developing standardized isolation methods, scalable production processes, and addressing ethical concerns regarding the biomedical use of breast milk. However, breast milk-derived exosomes present a novel and exciting opportunity for advancing cancer treatment, combining natural biocompatibility with therapeutic efficacy.

Keywords: Breast Milk; Exosomes; Cancer Therapy; Nanocarriers; Drug Delivery; Immune Modulation; Oncology

Citation

Haider R, Das GK, Ahmed Z. Breast Milk-Derived Exosomes as Natural Nanocarriers in Cancer Therapy in Adults. WebLog J Cancer Clin Res. wjcacr.2025.i1502. https://doi.org/10.5281/zenodo.17214006
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