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ARTICLE TYPE : RESEARCH ARTICLE

Published on :   27 Aug 2026, Volume - 2
Journal Title :   WebLog Journal of Dentistry and Oral Disorders | WebLog J Dent Oral Disord | WJDOD
Source URL:   weblog icon https://weblogoa.com/articles/wjdod.2026.h2702
Permanent Identifier (DOI) :   doi icon https://doi.org/10.5281/zenodo.22173150

Risk of Grade II Oligodendroglioma for Individuals with Periodontal Disease and Tooth Loss Versus Healthy Individuals: A Case – Control Study in Greece

Nikolaos Andreas Chrysanthakopoulos 1,2,3 *
Vassiliki Vazintari 4
Anna Vekkou 5
1Dental Surgeon (D. D. Sc), Oncologist (M. Sc), Specialized in Clinical Oncology, Cytology and Histopathology, Department of Pathological Anatomy, Medical School, University of Athens, Athens, Greece
2Resident in Maxillofacial and Oral Surgery, 401 General Military Hospital of Athens, Athens, Greece
3Ph. D. in Oncology (cand), Registrar in Dentistry, NHS of Greece, Athens, Greece
4MD, Registrar in Pathology, Ilioupoli Health Centre - NHS of Greece, Athens, Greece
5RN, MSc Public Health (cand), Ilioupoli Health Centre - NHS of Greece, Athens, Greece

Abstract

Background: Previous studies have demonstrated associations between Periodontal Disease and various malignancies, including oral/head and neck, esophageal, gastric, lung, kidney, and prostate cancers, as well as hematological malignancies.

Objective: This investigation aimed to evaluate the potential association between Periodontal Disease and the risk of developing Oligodendroglioma (grade II).

Methods: The study sample comprised 42 individuals diagnosed with oligodendroglioma (grade II) and 126 matched healthy controls, recruited from one dental and three medical private practices. Participants completed a standardized health questionnaire and underwent clinical periodontal examination. Periodontal status was evaluated using Probing Pocket Depth (PPD), Clinical Attachment Loss (CAL), and number of missing teeth.

Data were analyzed using univariate and multivariate logistic regression models, adjusting for potential confounding factors.

Results: Younger age (p=0.076, OR=0.819, 95% CI= 0.528-1.332) and the presence of deep periodontal pockets (p=0.089, OR= .786, 95% CI= 0.458-2.727) were positively associated, though not necessarily to a statistically significant degree, with the risk of developing Oligodendroglioma (grade II),whereas a positive family history of the disease (p=0.000, OR=3.479, 95% CI=2.103-6.022) demonstrated a statistically significant positive association.

Conclusion: This study suggests that younger age of individuals and deep periodontal pockets were positively, though non-significantly, associated with grade II Oligodendroglioma risk, whereas a positive family history of the disease exhibited a statistically significant positive association.

Keywords: Periodontal Disease; Oligodendroglioma (Grade II); Risk Factors; Adults

Citation

Chrysanthakopoulos NA, Vazintari V, Vekkou A. Risk of Grade II Oligodendroglioma for Individuals with Periodontal Disease and Tooth Loss Versus Healthy Individuals: A Case – Control Study in Greece. WebLog J Dent Oral Disord. wjdod.2026.h2702. https://doi.org/10.5281/zenodo.22173150
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