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ARTICLE TYPE : RESEARCH ARTICLE

Published on :   28 Sep 2026, Volume - 2
Journal Title :   WebLog Journal of Neurosurgery | WebLog J Neurosurg | WJNS
Source URL:   weblog icon https://weblogoa.com/articles/wjns.2026.i2801
Permanent Identifier (DOI) :   doi icon https://doi.org/10.5281/zenodo.23298691

Is Periodontal Disease a Risk Factor for Meningioma (WHO Grade I and II)? A Clinical and Questionnaire - Based Case - Control Study

Nikolaos Andreas Chrysanthakopoulos 1,2,3 *
Panagiotis Andreas Chrysanthakopoulos 4
Vassiliki Vazintari 5
1Dental Surgeon (DDSc), Oncologist (MSc), Specialized in Clinical Oncology, Cytology and Histopathology, Department of Pathological Anatomy, Medical School, University of Athens, Athens, Greece
2Resident in Maxillofacial and Oral Surgery, 401 General Military Hospital of Athens, Athens, Greece
3Ph. D. in Oncology (Cand), Registrar in Dentistry, NHS of Greece, Greecee
4MD, Neurosurgeon of Greek Armed Forces, former Director of the Neurosurgical Department of NIMTS Military Hospital of Athens, Athens, Greece
5MD, Registrar in Pathology, Ilioupoli Health Centre - NHS of Greece, Athens, Greece

Abstract

Background/Aim: Although periodontal disease has been epidemiologically linked to various systemic malignancies, comprehensive literature regarding its specific association with brain tumors remains scarce. The primary objective of this study was to investigate the potential association of periodontal disease with the risk of meningioma, (WHO Grade I and II), development.

Materials and Methods: This retrospective case-control study enrolled 74 individuals with newly diagnosed meningioma (WHO grade I and II) and148 age-and gender matched healthy controls. Prior to the initiation of any oncological intervention, all participants completed a standardized health questionnaire and underwent a rigorous clinical periodontal assessment. Periodontal health status was quantified utilizing Probing Pocket Depth (PPD), and Clinical Attachment Loss (CAL). To isolate the independent association between periodontal status and meningioma (WHO grade I and II) risk, data were subjected to univariate and multivariate logistic regression analyses, adjusting for potential confounding covariates.

Results: Following adjustment for gender, age, and smoking status, multivariate analysis revealed that patients with an elevated BMI (p=0.470, OR=1.562), exhibited a statistically significant predisposition toward an elevated risk of meningioma (WHO grade I and II) development, and these with more severe CAL (stages III/IV) (p=0.072, OR=1.386), were marginally associated with the risk of tumor development, associations that remained after adjustment for age, gender, and smoking history.

Conclusions: Patients with higher BMI, and advanced CAL were positively associated with the risk of developing meningioma (WHO grade I and II).

Keywords: Meningioma (WHO Grade I, and II); Periodontal Disease; Adults

Citation

Chrysanthakopoulos NA, Chrysanthakopoulos PA, Vazintari V. Is Periodontal Disease a Risk Factor for Meningioma (WHO Grade I and II)? A Clinical and Questionnaire - Based Case - Control Study. WebLog J Neurosurg. wjns.2026.i2801. https://doi.org/10.5281/zenodo.23298691
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