From Lesion Activity to Radiologic Regression: Longitudinal MRI Changes in Relapsing–Remitting Multiple Sclerosis Under Integrative Care

Abstract

Background: Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system in which Magnetic Resonance Imaging (MRI), cerebrospinal fluid findings, evoked potentials, and clinical follow-up remain central to diagnosis and monitoring. Many patients with MS also explore complementary or alternative approaches for symptom relief, although the evidence base for disease modification remains limited and inconsistent.

Case Presentation: A 38-year-old man with a 10-year history of relapsing-remitting MS presented with worsening fatigue, muscle weakness, numbness, tremor, impaired coordination, and unsteady gait despite prior corticosteroid-based relapse management. Brain MRI demonstrated multiple demyelinating lesions, and ancillary testing showed inflammatory cerebrospinal fluid findings and delayed sensory pathway conduction. The patient received an integrative regimen consisting of Gnaphalium, Arsenicum album, Echinacea purpurea, Gelsemium, Sulfur, and Kalium phosphoricum, together with physiotherapy, strengthening exercises, gait training, and lifestyle counseling.

Outcomes: Follow-up MRI demonstrated a reduction in enhancement and lesion burden compared with baseline imaging. Reported supraventricular white matter lesions decreased from 24 to 18, while total supratentorial lesions decreased from 107 to 59. Selected lesions reduced in size, and two previously measured lesions were reported as resolved. Whole-spine MRI did not show definite enhancing plaques at follow-up. Biochemical testing was largely within reference limits, with mild abnormalities in selected hematologic parameters.

Conclusion: This case documents temporal radiological improvement after multimodal management that included an alternative medicine regimen and rehabilitation. Because MS is relapsing-remitting and the case lacks a control comparator, standardized disability scores, exact dosing, and long-term follow-up, causality cannot be inferred. The report is best interpreted as hypothesis-generating and supports the need for careful neurologic monitoring and prospective evaluation of any adjunctive intervention.

Keywords: Multiple Sclerosis; Relapsing-Remitting Multiple Sclerosis; MRI; Complementary and Alternative Medicine; Homeopathy; Case Report

Citation

Rehan Uppal M, Saeed U, Uppal R, Ur Rehman I, Saad Uppal M, Zahid Piracha Z. From Lesion Activity to Radiologic Regression: Longitudinal MRI Changes in Relapsing–Remitting Multiple Sclerosis Under Integrative Care. WebLog J Radiol. wjr.2026. h2904. https://doi.org/10.5281/zenodo.22505131