The Evolution and Diversity of Enzymes Across Species: A Comparative Analysis of Enzyme Systems in Different Organisms

Abstract

Abstract: Enzymes are crucial biological catalysts that facilitate a wide array of biochemical reactions essential for life. The evolution and diversity of enzyme systems across species are central to understanding organismal adaptation and survival in varied environmental conditions. This paper explores the evolutionary mechanisms that drive the diversity of enzymes across different species, focusing on key enzyme families, metabolic pathways, and the role of genetic and environmental factors. By comparing enzyme systems in model organisms such as Escherichia coli, Saccharomyces cerevisiae, Drosophila melanogaster, and humans, we examine how enzymes have developed to meet specific metabolic demands and environmental challenges. Special attention is given to enzymes involved in central metabolic pathways, such as glycolysis, oxidative phosphorylation, and the citric acid cycle. The paper also delves into the evolution of enzyme systems in extreme environments, such as thermophilic bacteria and extremophiles, where enzymes exhibit remarkable stability and catalytic efficiency under extreme conditions. Additionally, the study highlights specific enzyme adaptations, such as lactase persistence in humans, cytochrome P450 diversity in detoxification, and hemoglobin evolution for oxygen transport. Understanding the evolutionary basis of enzyme diversity not only provides insights into fundamental biology but also opens doors for biotechnological advancements, including enzyme engineering and the development of novel therapeutic applications. This comparative analysis sheds light on how enzyme systems have diversified across species, offering a broader perspective on the evolutionary forces shaping life on Earth.

Keywords: Enzyme Evolution; Enzyme Diversity; Metabolic Pathways; Enzyme Adaptation; Thermophiles; Lactase Persistence; Cytochrome P450; Comparative Analysis, Extremophiles; Biochemical Evolution

Citation

Haider R, Das GK, Ahmed Z. The Evolution and Diversity of Enzymes Across Species: A Comparative Analysis of Enzyme Systems in Different Organisms. WebLog J Reprod Med. wjrm.2025.i0302. https://doi.org/10.5281/zenodo.17092378