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ARTICLE TYPE : RESEARCH ARTICLE

Published on :   03 Sep 2025, Volume - 1
Journal Title :   WebLog Journal of Reproductive Medicine | WebLog J Reprod Med
Source URL:   weblog iconhttps://weblogoa.com/articles/wjrm.2025.i0303
Permanent Identifier (DOI) :  doi iconhttps://doi.org/10.5281/zenodo.17092507

Sexual Enzymes and Their Influence on Female Reproductive and Sexual Function

Dr. Rehan Haider 1 *
Dr. Geetha Kumari Das 2
Dr. Zameer Ahmed 3
1Department of Pharmacy, Riggs Pharmaceutical, University of Karachi, Pakistan
2GD Pharmaceutical Inc., OPJS University, Rajasthan, India
3Assistant Professor, Department of Pathology, Dow University of Health Sciences (DUHS), Karachi, Pakistan

Abstract

Abstract: Sexual enzymes play a crucial role in regulating female reproductive and sexual health. These enzymes, including aromatase, phosphodiesterase type 5 (PDE5), hyaluronidase, lipoprotein lipase, and matrix metalloproteinases, are involved in various physiological processes that affect sexual arousal, lubrication, and tissue remodeling. Aromatase, for instance, regulates the conversion of androgens to estrogens, influencing libido and reproductive cycles. PDE5, while traditionally associated with male sexual health, also affects blood flow in women, contributing to genital arousal and sexual responsiveness.

Hyaluronidase plays a role in vaginal lubrication, while lipoprotein lipase impacts overall energy metabolism, indirectly influencing sexual health. Matrix metalloproteinases, involved in tissue remodeling, contribute to the changes that occur in the vagina and cervix during sexual arousal and childbirth.

Understanding the enzymatic mechanisms behind female sexual function is essential for improving treatments for sexual dysfunction and enhancing reproductive health. The balance of these enzymes, in combination with hormonal influences, ensures the proper physiological environment for sexual arousal, lubrication, and fertility.

This paper reviews the major sexual enzymes in women, their roles in sexual function, and the potential therapeutic implications for addressing sexual dysfunction and reproductive health issues. By investigating these enzymes, this research aims to provide a deeper understanding of the biochemical processes that govern female sexual and reproductive health, offering potential avenues for future therapeutic interventions.

Keywords: Sexual Enzymes; Female Sexual Function; Reproductive Health; Aromatase; PDE5; Hyaluronidase; Lubrication; Sexual Arousal; Matrix Metalloproteinases; Female Libido

Citation

Haider R, Das GK, Ahmed Z. Sexual Enzymes and Their Influence on Female Reproductive and Sexual Function. WebLog J Reprod Med. wjrm.2025.i0303. https://doi.org/10.5281/zenodo.17092507
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