ARTICLE TYPE : REVIEW ARTICLE
Published on : 14 Oct 2026,
Volume - 2
Journal Title :
WebLog Journal of Toxicology
| WebLog J Toxicol
| WJT
Source URL:
https://weblogoa.com/articles/wjt.2026.j1405
Permanent Identifier (DOI) :
The Environmental Exposome: Toxicity of Air, Water, Food, and Agricultural Pollutants and Emerging Strategies for Detoxification, Holobiotics, Environmental Hygiene, and Healthy Longevity
2Department of Pediatric Surgery, Southampton General Hospital, United Kingdom
3Rajkot Cancer Hospital, Rajkot, India
4Department of Pediatric Surgery, Evelina Children’s Hospital, London, United Kingdom
5Department of Pediatric Surgery, Nottingham University Hospitals, Nottingham, United Kingdom
6Lincoln Uni College, 2, Jalan Stadium, 47301 Petaling Jaya, Selangor, Malaysia
7J. Watumull Global Hospital & Research Centre, Delwara Road, Mount Abu, Rajasthan, India
8Department of Pediatric Surgery, Postgraduate Institute of Child Health and Research and KT Children Government University Teaching Hospital, Rajkot, Gujarat, India
Abstract
Background: Environmental pollution has emerged as a major determinant of global disease burden. Continuous exposure to airborne pollutants, contaminated water, pesticides, microplastics, heavy metals, and ultra-processed foods contributes significantly to chronic disease, premature aging, and mortality.
Objective: To review major environmental toxicants and evaluate current approaches to exposure reduction, detoxification, microbiome restoration, and healthy longevity.
Methods: A narrative review of recent literature was performed using published evidence from toxicology, environmental health, microbiome research, preventive medicine, and public health. Emphasis was placed on contemporary topics including PFAS, microplastics, regenerative agriculture, and holobiotic therapies.
Results: Environmental toxicants contribute to respiratory disease, metabolic syndrome, cardiovascular disorders, neurodegeneration, endocrine dysfunction, infertility, and cancer. Emerging evidence indicates that microbiome-targeted interventions may enhance host resilience against toxic insults. Holobiotics, including prebiotics, probiotics, postbiotics, and synbiotics, demonstrate promising effects on intestinal barrier integrity, inflammation, immune homeostasis, and toxicant metabolism.
Conclusion: Reducing environmental exposures while promoting microbiome health and sustainable living may become a cornerstone strategy for improving health span and longevity in the twenty-first century.
Keywords: Toxicology; Exposome; Air Pollution; PFAS; Microplastics; Microbiome; Probiotics; Postbiotics; Regenerative Agriculture; Longevity
Citation
Khatri LK, More AB, Govani PS, Zaparackaite I, More BB, Singh SJ, et al. The Environmental Exposome: Toxicity of Air, Water, Food, and Agricultural Pollutants and Emerging Strategies for Detoxification, Holobiotics, Environmental Hygiene, and Healthy Longevity. WebLog J Toxicol. wjt.2026.j1405. https://doi.org/10.5281/zenodo.23345429