Dr. Xu Li is a professor of medicine at Southern Medical University. He currently serves as the Director of Nanfang Hospital, Department of Emergency Medicine. He obtained his Ph.D. degree from First Military Medical University. Since 1998, Dr. Li’s research program has focused on the impact of the Renin-Angiotensin-Aldosterone System (RAS) on liver and lung fibrosis. His group has found that angiotensin II and aldosterone, respectively by influencing ROS generation and inflammation, trigger liver and lung fibrosis. His work has provided new insights into mechanisms and treatment of liver and lung fibrosis.

He is an evaluation expert of National Natural Science Foundation Committee and online evaluation expert of State Science and Technology Award. He is the guest editor of Frontiers in Immunology, and specially invited reviewer of several journals such as Journal of Hepatology, Advanced Science, Thorax, Small, Phytotherapy Research , International Immunopharmacology, Journal of Inflammation Research and so on. In the past 20 years, he has published papers in Redox Biology, Journal of Nanobiotechnology ,Free Radical Biology and Medicine, Antioxidant & Redox Signaling, American Journal of Respiratory Cell and Molecular Biology.

• Sepsis
• Inflammation
• Macrophage
• Nlrp3 Inflammasome
• Acute Liver Injury
• Acute Lung Injury
• Liver Fibrosis
• Oxidative Stress

• Wang G, Ma X, Huang W, Wang S, Lou A, Wang J, Tu Y, Cui W, Zhou W, Zhang W, Li Y, Geng S, Meng Y, Li X. Macrophage biomimetic nanoparticle-targeted functional extracellular vesicle micro-RNAs revealed via multiomics analysis alleviate sepsis-induced acute lung injury. Journal of Nanobiotechnology. 2024, 22(1):362. Co-Corresponding Author.
• Lin Y, Zhang Y, Li Y, Xu Q, Zhang Y, Chen T, Wang J, Li J, Gong J, Chen Z, Yang Q, Li X. EGCG suppressed activation of hepatic stellate cells by regulating the PLCE1/IP3/Ca2+ pathway. Eur J Nutr. 2024 Sep 26. Epub ahead of print. Corresponding Author.
• Fang J, Huang P, Cui W, Lin Y, Rong D, Li X. Comprehensive therapeutic efficacy analysis of intravenous immunoglobulin in treating sepsis-induced coagulopathy: a single-center, retrospective observational study. Shock. 2024, 1;62(1):4-12. Corresponding Author.
• Chen T, Zhang Y, Zhang Y, Ning Z, Xu Q, Lin Y, Gong J, Li J, Chen Z, Meng Y, Li Y, Li X. Autophagic degradation of MVBs in LSECs promotes Aldosterone induced-HSCs activation. Hepatol Int.2024,18(1):273-288.Corresponding Author.
• Zhang Y, Zhang Y, Chen T, Lin Y, Gong J, Xu Q, Wang J, Li J, Meng Y, Li Y, Li X. Caveolin-1 depletion attenuates hepatic fibrosis via promoting SQSTM1-mediated PFKL degradation in HSCs. Free Radic Biol Med. 2023, 204:95-107. Co-Corresponding Author.
• Guo Q, Qu P, Cui W, Liu M, Zhu H, Chen W, Sun N, Geng S, Song W, Li X, Lou A. Organism type of infection is associated with prognosis in sepsis: an analysis from the MIMIC-IV database. BMC InfectDis.2023,23(1):431. Co-Corresponding Author.
• Wang J, Li J, Lou A, Lin Y, Xu Q, Cui W, Huang W, Wang G, Li Y, Sun J, Gong J, Guo Q, Qiu H, Meng Y, Li X. Sacubitril/valsartan alleviates sepsis-induced acute lung injury via inhibiting GSDMD-dependent macrophage pyroptosis in mice. FEBS J. 2023,290(8):2180-2198. Co-Corresponding Author.
• Wang W, Zhang Y, Huang W, Yuan Y, Hong Q, Xie Z, Li L, Chen Y, Li X, Meng Y. Alamandine/MrgD axis prevents TGF-β1-mediated fibroblast activation via regulation of aerobic glycolysis and mitophagy. J Transl Med. 2023,21(1):24. Co-Corresponding Author.
• Hong Q, Zhang Y, Lin W, Wang W, Yuan Y, Lin J, Xie Z, Li X, Meng Y. Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis. J Immunol Res. 2022. 2022: 2291877.（IF:4.1）Co-Corresponding Author
• Ouyang H, Geng S, Zhou Y, Wang J, Zhan J, Shang Z, Jia Y, Yan W, Zhang Y, Li X, Liu W. The increase of PTSD in front-line health care workers during the COVID-19 pandemic and the mediating role of risk perception: a one-year follow-up study. Transl Psychiatry. 2022, 12(1):180. Co-Corresponding Author.
• Yue Zhang , Ting Li , Miaoxia Pan , Wei Wang , Wenhui Huang , Yafei Yuan, Zhanzhan Xie, Yixin Chen, Jun Peng , Xu Li , Ying Meng.SIRT1 prevents cigarette smoking-induced lung fibroblasts activation by regulating mitochondrial oxidative stress and lipid metabolism. J Transl Med,2022,20(1):222. Co-Corresponding Author.
• Yuan Y, Wang W, Zhang Y, Hong Q, Huang W, Li L, Xie Z, Chen Y, Li X, Meng Y. Apelin-13 Attenuates Lipopolysaccharide-Induced Inflammatory Responses and Acute Lung Injury by Regulating PFKFB3-Driven Glycolysis Induced by NOX4-Dependent ROS. J Inflamm Res. 2022, 15:2121-2139. Co-Corresponding Author.
• Wang G, Jin S, Huang W, Li Y, Wang J, Ling X, Huang Y, Hu Y, Li C, Meng Y, Li X. LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome. Cell Death Discov. 2021;7(1):337. Co-Corresponding Author.
• Guozhen Wang, Weichang Huang, Shuanghu Wang, Jun Wang, Wanfu Cui, Wenyong Zhang, Anni Lou, Shiyu Geng, Xu Li. Macrophagic Extracellular Vesicle CXCL2 Recruits and Activates the Neutrophil CXCR2/PKC/NOX4 Axis in Sepsis. The Journal of Immunology 2021 Oct 15;207(8):2118-2128. Corresponding Author.
• Sun Na-Na, Zhang Yue, Huang Wen-Hui, Zheng Bo-Jun, Jin Si-Yi, Li Xu, Meng Ying*. Macrophage exosomes transfer angiotensin II type 1 receptor to lung fibroblasts mediating bleomycin-induced pulmonary fibrosis. Chinese Medical Journal 2021, 134(18): 2175-2185 Co-Corresponding Author
• Yue Zhang, Wenhui Huang, Zemao Zheng, Wei Wang, Yafei Yuan, Qiaohui Hong, Jiajia Lin, Xu Li, Ying Meng. Cigarette smoke-inactivated SIRT1 promotes autophagy-dependent senescence of alveolar epithelial type 2 cells to induce pulmonary fibrosis. Free Radic Biol Med. 2021;166:116-127. Co-Corresponding Author
• Geng S, Zhou Y, Zhang W, Lou A, Cai Y, Xie J, Sun J, Zhou W, Liu W, Li X. The influence of risk perception for COVID-19 pandemic on posttraumatic stress disorder in healthcare workers: A survey from four designated hospitals. Clin Psychol Psychother 2021 Feb 16:10.1002/cpp.2564. Epub ahead of print. Co-Corresponding Author
• Qu R, Hu L, Ling Y, Hou Y, Fang H, Zhang H, Liang S, He Z, Fang M, Li J, Li X, Chen C. C-reactive protein concentration as a risk predictor of mortality in intensive care unit: a multicenter, prospective, observational study. BMC Anesthesiol 2020 20(1):292. Co-Corresponding Author
• Huang Y, Li Y, Lou A, Wang GZ, Hu Y, Zhang Y, Huang W, Wang J, Li Y, Zhu X, Chen T, Lin J, Meng Y, Li X. Alamandine attenuates hepatic fibrosis by regulating autophagy induced by NOX4-dependent ROS. Clin Sci (Lond) 2020; 134(7):853-869. Co-Corresponding Author
• Yue Li, Xintao Zhud, Guozhen Wanga, Huasheng Tongd, Lei Su, Xu Li. Proteomic analysis of extracellular vesicles released from heat-stroked hepatocytes reveals promotion of programmed cell death pathway. Biomedicine & Pharmacotherapy, 2020,129 :110489. Co-Corresponding Author
• Li Y, Zhang YJ, Chen TT, Huang Y, Zhang Y, Geng SY and Li X. Role of aldosterone in the activation of primary mice hepatic stellate cell and liver fibrosis via NLRP3 inflammasome. Journal of Gastroenterology and Hepatology 2020;35(6):1069-1077. Corresponding Author
• Guozhen Wang, Siyi Jin, Xuguang Ling, Yang Li, Ye Hu, Yijie Zhang, Yun Huang, Tingting Chen, Jiayi Lin, Zuowei Ning, Ying Meng, Xu Li. Proteomic profiling of LPS-induced macrophage exosomes indicate their involvement in acute liver injury. Proteomics 2019;19(3):e1800274. Co-Corresponding Author
• Ying Meng , Miaoxia Pan, Bojun Zheng, Yan Chen, Wei Li, Qianjie Yang, Zemao Zheng, Nana Sun, Yue Zhang, Xu Li, Autophagy attenuates angiotensin II-induced pulmonary fibrosis by inhibiting redox imbalance-mediated NLRP3 inflammasome activation, Antioxidants & Redox Signaling 2019;30(4): 520-541. Corresponding Author
• Ming Zhang, Xintao Zhu , Huasheng Tong, Anni Lou , Yue Li , Yang Li , Lei Su , Xu Li. AVE 0991 Attenuates Pyroptosis and Liver Damage after Heatstroke by Inhibiting the ROS-NLRP3 Inflammatory Signalling Pathway. Biomed Res Int 2019:1806234. Co-Corresponding Author
• Yue-hua You, Yun H, Dan Wang, Yang Li, Guo-zhen Wang, Si-yi Jin，Xin-tao Zhu, Bin Wu, Xin-ya Du, Xu Li. Angiotensin (1-7) inhibits arecoline-induced migration and collagen synthesis in human oral myofibroblasts via inhibiting NLRP3 inflammasome. J Cell Physiol 2019;234(4):4668-4680. Corresponding Author
• Xiaoying Luo, Dan Wang, Xintao Zhu, Guozhen Wang, Yuehua You, Zuowei Ning, Yang Li, Siyi Jin, Yun Huang, Ye Hu, Tingting Chen, Ying Meng, Xu Li, Autophagic degradation of caveolin-1 promotes liver sinusoidal endothelial cells defenestration, Cell Death＆Disease 2018;9(5):576. Co-Corresponding Author
• Xiaoying Luo，Dan Wang，Xuan Luo，Xintao Zhu，Guozhen Wang，Zuowei Ning，Yang Li，Xiaoxin Ma，Renqiang Yang，Siyi Jin，Yun Huang，Ying Meng ，Xu Li .Caveolin 1-related autophagy initiated by aldosterone-induced oxidation promotes liver sinusoidal endothelial cells defenestration. Redox Biol 2017;13:508-521. Co-Corresponding Author
• Zuo-Wei Ning, Xiao-Ying Luo, Guo-Zhen Wang, Yang Li, Miao-Xia Pan, Ren-Qiang Yang, Xu-Guang Ling, Shan Huang, Xiao-Xin Ma , Si-Yi Jin , Dan Wang , Xu Li*. MicroRNA-21 Mediates Angiotensin II-Induced Liver Fibrosis by Activating NLRP3 Inflammasome/IL-1β Axis via Targeting Smad7 and Spry1. Antioxid Redox Signal 2017;27(1):1-20. Corresponding Author
• Shuang-Ming Cai, Ren-Qiang Yang, Yang Li, Zuo-Wei Ning, Li-Li Zhang,Gao-Su Zhou, Wei Luo, Da-Huan Li, Yan Chen, Miao-Xia Pang, Li X.Angiotensin-(1-7) improve liver fibrosis by regulating the NLRP3 inflammasome via redox balance modulation. Antioxid Redox Signal 2016;24(14):795-812. Corresponding Author
• Li-Li Zhang, Shan Huang,Xiao-Xin Ma, Wen-Yong Zhang, Dan Wang, Si-Yi Jin, Yan-Ping Zhang, Yang Li, Xu Li.Angiotensin(1-7) attenuated Angiotensin II-induced hepatocyte EMT by inhibiting NOX-derived H2O2-activated NLRP3 inflammasome/IL-1beta/Smad circuit. Free Radic Biol Med 2016; 97: 531-543. Corresponding Author
• Ying Meng, Ting Li, Gaosu Zhou, Yan Chen, Changhui Yu, Miaoxia Pang, WeiLi, Yang Li, Wenyong Zhang, Xu Li*. The Angiotensin- converting enzyme2/Angiotensin (1-7)/MasR axis Protects against Lung Fibroblast Migration and Lung Fibrosis by Inhibiting the NOX4-derived ROS-mediated RhoA/Rho kinase Pathway. Antioxid Redox Signal 2015; 22(3):241-258 Corresponding Author
• Ying Meng, Changhui Yu, Wei Li, Ting Li, Wei Luo, Shan Huang, Pingsheng Wu,Shaoxi Cai, Xu Li. Angiotensin-converting enzyme 2/Angiotensin-(1-7)/MasR axis protects against lung fibrosis by inhibiting the MAPK/NF-κB pathway. Am J Respir Cell Mol Biol 2014;50(4): 723-736. Corresponding Author
• Huang ML, Li X, Meng Y, Xiao B, Ma Q, Ying SS, Wu PS, Zhang ZS. Upregulation of angiotensin-converting enzyme (ACE) 2 in hepatic fibrosis by ACE inhibitors. Clin Exp Pharmacol Physiol 2010;37(1):e1-6.
• Li X, Meng Y, Wu P, Zhang Z, Yang X. Angiotensin II and Aldosterone stimulating NF-kappaB and AP-1 activation in hepatic fibrosis of rat. Regul Pept 2007;138(1):15-25.

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