Dr. Yanying Liu is currently a professor teaching Medical Pathogenic Microbiology and Parasitology, Immunology, and Biochemistry at the Qingdao Huanghai University in China. She received her PhD in Neurobiology from the Capital Medical University (China) in 2006. In the past decade or so, she has worked as a postdoc or research staff scientist engaged in scientific research related to neuroscience at SUNY Upstate Medical University or the University of South Dakota in the USA. Dr. Liu’s research is related to several areas such as Alzheimer’s disease, Huntington’s disease, stroke, and stem cells. Her current research interests are the mechanism of the aging process, brain hypoxia, and stroke.

• Stroke
• Alzheimer’s Disease
• Aging
• Brain Hypoxia Injury
• Stem Cells

• Yanying Liu. Alzheimer’s disease, aging, and cannabidiol treatment: a promising path to promote brain health and delay aging. Mol Biol Rep. (2024) 51(1):121.
• Yanying Liu. Zebrafish as a model organism for studying pathologic mechanisms of neurodegenerative diseases and other neural disorders. Cell Mol Neurobiol. 2023 Aug;43(6):2603-2620.
• Beibei Ni, Yanying Liu, Meng Dai, Jun Zhao, Yu Liang, Xue Yang, Bing Han, Man Jiang. The role of cannabidiol in aging. Biomed & Pharmacother. 2023 165:115074.
• Yanying Liu, Kalpana Subedi, Aravind Baride, Svetlana Romanova, Eduardo Callegari, Christa C. Huber, Xuejun Wang and Hongmin Wang. Peripherally misfolded proteins exacerbate ischemic stroke-induced neuroinflammation and brain injury. J Neuroinflamm. 2021 Jan 20; 18(1)29.
• Yanying Liu,Christa Caye Huber, Hongmin Wang. Disrupted blood-brain barrier in 5×FAD mouse model of Alzheimer’s disease can be mimicked and repaired in vitro with neural stem cell-derived exosomes. Biochem and Biophys Res Commun. 2020 April 23, 525(1) 192-196.
• Yanying Liu and Hongmin Wang. Modeling sporadic Alzheimer’s disease by efficient direct reprogramming of the elderly derived disease dermal fibroblasts into neural stem cells. J Alzheimers Dis. 2020; 73 (3):919-933.
• Yanying Liu, Shelley Feng, Kalpana Subedi, Hongmin Wang. Attenuation of ischemic stroke-caused brain injury by a monoamine oxidase inhibitor involves improved proteostasis and reduced neuroinflammation. Mol Neurobiol. 2020 Feb; 57 (2):937-948. Epub 2019 Oct 15.
• Yanying Liu, Jia-Wei Min, Shelley Feng, Kalpana Subedi, Fangfang Qiao, Emily Mammenga, Eduardo Callegari and Hongmin Wang. Therapeutic role of a cysteine precursor, OTC, in ischemic stroke is mediated by improved proteostasis in mice. Transl Stroke Res. 2020 Feb; 11(1):147-160. Epub 2019 May 2.
• Xingzhi Guo, Yanying Liu, David Morgan, Li-Ru Zhao, Reparative effects of stem cell factor and granulocyte colony-stimulating factor in aged APP/PS1 mice, Aging Dis. 2020 Dec 1;11(6):1423-1443.
• Jiawei Min, Yanying Liu, David Wang, Fanfang Qiao, Hongmin Wang. The non-peptidic δ-opioid receptor agonist Tan-67 mediates neuroprotection post-ischemically and is associated with altered amyloid precursor protein expression, maturation and processing in mice. J Neurochem. 2018 Feb; 144 (3):336-347. Epub 2017 Dec 19.
• Yanying Liu, Fangfang Qiao, Leiferman PC, Ross A, Schlenker EH, Hongmin Wang. FOXOs modulate proteasome activity in human-induced pluripotent stem cells of Huntington's disease and their derived neural cells. Hum Mol Genet. 2017 Nov 15; 26 (22):4416-4428.
• Oludotun O Adegoke, Fanfang Qiao, Yanying Liu, Kirsty Longley, Shelley Feng, Hongmin Wang. Overexpression of ubiquilin-1 alleviates Alzheimer's disease-caused cognitive and motor deficits and reduces amyloid-β accumulation in mice. J Alzheimers Dis. 2017; 59(2):575-590.
• Yanying Liu, Fangfang Qiao, Hongmin Wang. Enhanced proteostasis in post-ischemic stroke mouse brains by ubiquilin-1 promotes functional recovery. Cell Mol Neurobiol. 2017 Oct; 37(7):1325-1329. Epub 2016 Dec 7.
• Yanying Liu, Maria Popescu, Sharon Longo, Mei Gao, Dongliang Wang, SandraMcGillis, Li-Ru Zhao. Fibrinogen reduction and motor function improvement by hematopoietic growth factor treatment in chronic stroke in aged mice: A Treatment Frequency Study. Cell Transplant. 2016; 25: 729-734.
• Xiaoyun Liu, Maria E. Gonzalez-Toledo, Austin Fagan, Wei-Ming Duan, Yanying Liu, Siyuan Zhang, Bin Li, Chun-Shu Piao, Lila Nelson, Li-Ru Zhao. Stem cell factor and granulocyte olony-stimulating factor exhibit therapeutic effects in a mouse model of CADASIL. Neurobio Dis. 2015 Jan; 73:189-203. Epub 2014 Sep 2.
• Yanying Liu, Yuanchao Xue, Samantha Ridley, Dong Zhang, Khosrow Rezvani, Xiang-Dong Fu, Hongmin Wang. Direct reprogramming of Huntington's disease patient fibroblasts into neuron-like cells leads to abnormal neurite outgrowth, increased cell death, and aggregate formation. PLoS One. 2014; 9(10): e109621.
• Yanying Liu, Casey L. Hettinger, Dong Zhang, Khosrow Rezvani, Xuejun Wang and Hongmin Wang. The proteasome function reporter GFPu accumulates in young brains of the APPswe/PS1dE9 Alzheimer's disease mouse model. Cell Mol Neurobiol. 2014 Apr 01; 34(3): 315-322. Epub 2013 Dec 21.
• Yanying Liu, Lanhai Lu, Casey L. Hettinger, Gaofeng Dong, Dong Zhang, Khosrow Rezvani, Xuejun Wang and Hongmin Wang. Ubiquilin-1 protects cells from oxidative stress and ischemic stroke caused tissue injury in mice. J Neurosci. February 19, 2014, 34(8):2813-2821.
• Yanying Liu, Casey L. Hettinger, Dong Zhang, Khosrow Rezvani, Xuejun Wang and Hongmin Wang. Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease. J Neurochem. 2014 May; 129(3): 539-547. Published online 2014 January 18.
• Yanying Liu, Bhushan Vijay Nagpure, Peter T.-H Wong, Jinsong Bian. Hydrogen sulfide protects SH-SY5Y neuronal cells against d-galactose induced cell injury by suppression of advanced glycation end products formation and oxidative stress. Neurochem Int. 2013 Apr; 62(5):603-609.
• Yanying Liu, Anna Sparatore, Piero Del Soldato, Jin-Song Bian. ACS84, a novel hydrogen sulfide-releasing compound, protects against amyloid -induced cell cytotoxicity. Neurochem Int. 2011, 58:591-598.
• Yanying Liu, Min Qiang, Yan Wei, Rongqiao He. A novel molecular mechanism for nitrated α-synuclein-induced cell death. J Mol Cell Biol. 2011, 3:239-249.
• Yanying Liu, Anna Sparatore, Piero Del Soldato, Jin-Song Bian. H2S releasing aspirin protects amyloid beta induced cell toxicity in BV-2 microglial cells. Neuroscience. 2011, 193:80-88.
• Yanying Liu, Jin-Song Bian. Hydrogen sulfide protects amyloid beta induced cell toxicity in microglia. J Alzheimers Dis. 2011 Jan 7, 22: 1189-1200.
• Yanying Liu, Rongqiao He. Fasting inducing a high level of 3-nitrotyrosine in the brain of rats. Neurosci Lett. 2010, 472:204-209.

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