Editor Profile
Dr. K. Krishnan MD, FRCP, FACP, Dip Hem (London)
Emeritus Professor
Present
East Tennessee State University - Quillen College of Medicine
Johnson City, TN 37614
United States
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- Rare Disorders in Hematology
- Hematological Disorders in India
- Molecular Hematology
- Benign Hematology
- Krishnan K, Badarinath S, Bhusnurmath SR. Vascular Complications of hepaticamoebiasis - A retrospective analysis. Ind J Pathol Microbiol, 1986. 29: 293-97.
- Krishnan K, Nair L, Das Gupta A: Hemoglobin A2 estimation: A comparative evaluation of electrophoresis and chromatography. Indian Journal of Hematology 4,30-33, 1986.
- Wood DJ, Krishnan K, Stocks PJ, Morgan E, Ward MJ. Catamenial Haemoptysis, arare cause. Thorax, 1993. 48: 1048.
- Krishnan K, Adams P, Silveira S, Sheldon S, Dabich L. Therapy-related acutemyeloid leukemia following immunosuppression with azathioprine for polymyositis. Clin Lab Haemat, 1994. 16: 285-89. PMID: 7828416.
- Krishnan K, Bockenstedt P. Paraneoplastic cerebellar degeneration: a rarepresentation of Hodgkin’s disease. Clin Lab Haemat, 1994. 16: 359-62. PMID:7537642
- Krishnan K, Silveira S. Paraneoplastic cutaneous leucocytoclastic vasculitis inchronic myeloid leukemia: case report and review of the literature. Eur J Haematol.1994 Mar. 52(3): 187-8. PMID: 8168601.
- Krishnan K, Ross CW, Adams PT, Pereira A, Roth MS. Neural-cell adhesionmolecule (CD 56)-positive, t (8;21) acute myeloid leukemia (AML M-2) and granulocyticsarcoma. Ann Hematol,1994. Dec.69(6): 321-3.PMID:7527661
- Wille RT, Krishnan K, Cooney K, Bach D, Martinez F. Familial association of primary pulmonary hypertension and a new, low oxygen affinity β-chain hemoglobinopathy, Hb Washtenaw. Chest, 1996. 109: 848-50.
- Krishnan K, Sheldon S. A new translocation, t(3;6)(q12;q24) associated with chronic myelomonocytic leukemia (CMML) and marrow fibrosis. Clin Lab Haemat, 18: 47-49,1996. PMID: 9118605
- Burney K, Krishnan K, Ruffin MT, Zhang D, Brenner DE. Adherence to single dailydose of aspirin in a chemoprevention trial: an evaluation of self-report and microelectronic monitoring. Arch Fam Med, 1996. 5: 297-300. PMID: 8620270
- Krishnan K, Ross CW, Bockenstedt PL, Adams PT. Successful treatment ofautoimmune neutropenia with recombinant granulocyte-colony stimulating factor(R-metHuG-CSF).Clin Lab Haemat, 1997. 19: 105-109. PMID: 9218149.
- Krishnan K, Martinez F, Wille RT, Head C, Shih DT, Jones RT, Fairbanks VF, Dabich L. Hb Washtenaw(α2β211(A8) val−phe):a new electrophoretically, silent low oxygen affinity variant hemoglobin associated with anemia and chronic cyanosis. Hemoglobin, 1997. 18: 285-95.
- Ruffin MT, Krishnan K, Rock CL, Normolle D, Vaerten MA, Crowell J, Kelloff G, Boland CR, Brenner DE. Suppression of human colorectal prostaglandins: determining the lowest effective aspirin dose.J Natl Cancer Inst, 1997. 89: 1152-60.PMID: 9262254.
- Krishnan K, Ruffin MT 4th, Brenner DE. Cancer chemoprevention. A new way totreatcancerbeforeithappens.PrimCare.1998Jun.25(2):361-79.PMID:9628956.
- Crider S, Hamati-Krozser A, Krishnan K. Isolated pancreatic extra-medullary hematopoiesis (EMH): case report and literature review. Acta Haematologica, 1998.99: 38-40. PMID: 9490565
- Krishnan K, Krishnaswamy G. Severe Bactrim-induced neutropenia with reversal ofCD4/CD8 lymphocyte ratio and response to recombinant granulocyte stimulatingfactor (R-metHUG-CSF).Clin Lab Haemat [letter], 1998. 20: 187-188.
- McCoskey E, Mehta J, Krishnan K, Roy TM. Right atrial myxoma with extra-cardiac manifestations. Chest, 2000. 118: 547-549. PMID: 10936155.
- Araneda M, Krishnan V, Hall K, Kalbfleisch J, Krishnaswamy G, Krishnan K. Reactive and Clonal thrombocytosis: Proinflammatory and Hematopoietic Cytokines and Acute Phase Proteins. Southern Medical Journal, 2001. 94: 417-420. PMID:11332909.
- Krishnan K, Ruffin MT, Normolle D, Shureiqi I, Burney K, Bailey J, Peters-Golden M,Rock C, Brenner DE. Colonic mucosal prostaglandin E2 and cyclooxygenase expression before and after low aspirin doses in high-risk and normal-risk subjects for colorectal cancer. Cancer Epidemiol, Biomarkers and Prev, 2001 May. 10: 447-53. PMID: 11352853
- Krishnan K, Brenner DE. Prostaglandin inhibitors and the chemoprevention ofnoncolonic malignancy.Gastroenterol Clin North Am. 2001 Dec. 30(4): 981-1000.PMID: 11764539.
- Krishnan K, Karnad AB. The rise and fall of hormone replacement therapy: oncologists 'views. South Med J. 2002 Sep. 95(9): 963-5. PMID:12356135
- Patel P, Olive KE, Krishnan K. Septic discitis: an important cause of back pain.South Medical J, July 2003. 96(7): 692-5. PMID: 12940323
- Aljitawi OS, Krishnan K, Abdel-Rahman F, Curtis BR, Bougie DW, and Aster RH. Serologically documented Loracarbef (lorabid)-induced immune thrombocytopenia. American Journal of Hematology, 2003. 73: 41-43. PMID: 12701119
- Campbell S, Stone W, Whaley S, Krishnan K. Development of gamma(gamma)-tocopherol as a colorectal cancer chemopreventive. Crit Rev Oncol Hematol. 2003 Sep. 47(3): 249-59. PMID: 12962899
- Campbell S, Stone WL, Whaley S, Min Q, Krishnan K. Gamma(γ)-tocopherol upregulates peroxisome proliferator activated receptor (PPAR) gamma expression inSW480 human colon cancer cell lines.BMC Cancer, 2003 Oct. 3: 25. PMID:14521714
- Krishnan K, Aoki T, Ruffin MT, Normolle D, Boland RC, Brenner DE.Effects of lowdose aspirin (81 mg) on Proliferating Cell Nuclear Antigen (PCNA) and Amaranthus caudatus (ACA) labeling in normal-risk and high-risk human subjects for colorectal cancer. Cancer Detection and Prevention (Elsevier Science), 2004. 28(2): 107-113.PMID: 15068834
- Stone WL, Krishnan K, Campbell SE, Qui M, Whaley SG, Yang H. Tocopherols and the treatment of colon cancer. Ann N Y Acad Sci, 2004 Dec. 1031: 223-33.
- Campbell S, Stone W, Lee S, Whaley S, Yang H, Qui M, Goforth P, Sherman D, Mc Haffie D, Krishnan K. Comparative Effects of RRR Alpha- and RRR Gamma-Tocopherol on Proliferation and Apoptosis in Human Colon Cancer Cell Lines. BMC Cancer 2006. 6: 13. PMID: 16417629
- Ahn K, Sethi G, Krishnan K, Aggarwal B. γ-TocotrienolInhibits Nuclear Factor-kappa B Signaling Pathway Through Inhibition of RIP and TAK1 Leading to Suppression of Antiapoptotic Gene Products and Potentiation of Apoptosis. J Biol Chem. 2007 Jan 5. 282(1):809-820. Epub 2006 Nov 17. PMID: 17114179
- Behringer B, Friedell H, Dorgan KA, Hutson SP, Naney C, Phillips A, Cantrell S, Krishnan K, Cantrell ES. Understanding the challenges of reducing cancer inAppalachia: addressing a place-based health disparity population. California Journal of Health Promotion- Special Issue on Health Disparities and Social Justice, 2007May. 5: 40-49.
- Campbell S, Whaley SG, Phillips R, Aggarwal BB, Stimmel JB, Leesnitzer L, Blanchard SG, Stone WL, Krishnan K. Gamma-tocotrienol and prostate cancer: theregulation of two independent pathways to potentiate cell growth inhibition andapoptosis. Journal of Oil Palm Research- Special Issue, 2008 October. p.33-43.
- Song S, Krishnan K, Liu K, Bresalier RS. Polyphenon E inhibits growth of human Barrett’s and aerodigestive adenocarcinoma cells by suppressing Cyclin D1 expression. Clinical Cancer Research, 2009 Jan.15(2): 622-31.PMID:19147768
- Campbell SE, Musich PR, Whaley SG, Stimmel JB, Leesnitzer LM, Dessus-BabusS, Duffourc M, Stone W, Newman RA, Yang P, Krishnan K. Gamma TocopherolUpregulates the Expression of 15-S-HETE and Induces Growth Arrest Through aPPAR Gamma-Dependent Mechanism in PC-3 Human Prostate Cancer Cells. Nutrition and Cancer, 2009 Sept. 61: 649-662. PMID: 19838939
- Moukharskaya J, Vikas P, Swan Jr. P, Krishnan K, Roy T, Byrd, Jr. RP. Primary Mediastinal Yolk Sac Tumor: A Rarely Encountered Neoplasm. Journal of the Kentucky Medical Association, 2010 Aug. 108.
- Campbell SE, Rudder B, Phillips RB, Whaley SG, Stimmel JB, Leesnitzer LM, Lightener J, Dessus-Babus S, Duffourc M, Stone WL, Menter DG, Newman RA,Yang P, Aggarwal BB, Krishnan K. γ-Tocotrienol induces growth arrest through anovel pathway with TGF2 in prostate cancer.Free Radical Biology and Medicine,2011 May 15. 50(10): 1344-54. PMID: 21335085
- Shin-Kang S, Ramsauer VP, Lightner J, Chakraborty K, Stone W, Campbell S,Reddy S, Krishnan K. Tocotrienols inhibit Akt and Erk activation and suppress pancreatic cancer cell proliferation by suppressing the ErbB2 pathway. Free Radic Biol Med, 2011 Sep 15. 51(6): 1164-74. PMID: 21723941
- Behringer B, Krishnan K. Understanding the role of religion in cancer care in Appalachia. South Med J, 2011 Jan 4. PMID: 21206404
- David G Menter, Victoria P Ramsauer, Sam Harirforoosh, Kanishka Chakraborty, Peiying Yang, Linda Hsi, Robert A Newman, Koyamangalath Krishnan: Differential Effects of Pravastatin and Simvastatin on the Growth of Tumor Cells from Different Organ Sites. PLoS ONE
- Yu Lin Jiang, Christopher A McGoldrick, Deling Yin, Jing Zhao, Vini Patel, Marianne F Brannon, Janet W Lightner, Koyamangalath Krishnan, William L Stone: A specific molecular beacon probe for the detection of human prostate cancer cells, Bioorg Med Chem Lett. 2012 Jun 1. 22(11): 3632-8. Epub 2012 Apr19. Jun 1; 22(11): 3632-8. PMID: 22572577
- Chakraborty K, Bossaer J, Patel R, Krishnan K. Successful treatment of nilotinib-induced pleural effusion with prednisone. Journal of Oncology Pharmacy Practice J Oncol Pharm Pract. 2013 Jun; 19(2):175-7. doi:10.1177/1078155212447530. Epub 2012 Nov 15.
- Christan M Thomas, Robert C Wood, Jarrett E Wyatt, Morgan H Pendleton, Ruben D Torrenegra, Oscar E Rodriguez, Sam Harirforoosh, Maria Ballester, Janet Lightner, Koyamangalath Krishnan, Victoria P Ramsauer: Anti-Neoplastic Activity of Two FlavoneIsomers Derived from Gnaphalium elegans and Achyrocline bogotensis. PLoS ONE 06/2012; 7(6):e39806. DOI:10.1371/journal.pone.0039806
- Fadi Abu-Shahin, William Stone, Victoria Ramsauer, Koyamangalath Krishnan: A Summary of the Prostate Cancer Prevention Trials With a Focus on the Role of Vitamin E. Home Health Care Management & Practice 08/2012; 25(1): 23-28. DOI:10.1177/1084822312453048
- Jurdi A, Krishnan K, Chakraborty K: "A 'Double-Hit' Bone Marrow-Rare Co-occurrence of Two Different Pathologies, J Community Support Oncol. 2014Jan;12(1):33-4. PMID: 24971401 [PubMed - in process]
- Christopher A. McGoldrick, Yu-Lin Jiang, Victor Paromov, Marianne Brannon, Koyamangalath Krishnan, William L. Stone. Identification of Oxidized Protein Hydrolase as a Potential Prodrug Target in Prostate Cancer. BMC Cancer. 2014 Feb10;14:77. doi: 10.1186/1471-2407-14-77. PMID: 24512522 [PubMed - in process]
- McGoldrick CA, Jiang YL, Brannon M, Stone W, Krishnan K. A Novel Acetyl-alanine NO-Donating Prodrug that Selectively Induces Apoptosis in Prostate Cancer Cells.BMC Cancer. 2014 Sep 18;14:675. doi: 10.1186/1471-2407-14-675.PMID:25234292.
- Rogers M, Kalra S, Moukharskaya J, Chakraborty K, Niyazi, M, Krishnan, K, Lightner J, Brannon M, Stone WL, PalauV. Synergistic inhibition of prostate cancer cell (PC3) growth in vitro with low dose combinations of Simvastatin and Alendronate, Anticancer Research 35: 1851-1860, 2015
- Gorniewicz J, Floyd M, Krishnan K, Bishop TW, Tudiver F, Lang F. Breaking bad news to patients with cancer: A randomized control trial of a brief communication skills training module incorporating the stories and preferences of actual patients. Patient
- Patel ND, Chakrabory K, Messmer G, Krishnan K, Bossaer JB. Severe sunitinib-induced myelosuppression in a patient with a CYP 3A4 polymorphism. JOncol Pharm Pract. 2017 Jan 1:1078155217724863. doi:10.1177/1078155217724863. [Epub ahead of print]. PMID:28782406
- Palau VE, Chakraborty K, Wann D, Lightner J, Hilton K, Brannon M, Stone W, Krishnan K. γ-Tocotrienol induces apoptosis in pancreatic cancer cells by upregulation of ceramide synthesis and modulation of sphingolipid transport. BMC Cancer. 2018 May 16;18(1):564. doi: 10.1186/s12885-018-4462-y. PMID:29769046.
- Han CG, O'Brien KJ, Coon LM, Majerus JA, Huryn LA, Haroutunian SG, Moka N, Introne WJ, Macnamara E, Gahl WA, Malicdan MCV, Chen D, Krishnan K, Gochuico BR. Severe bleeding with subclinic aloculocutaneou salbinism in a patient with a novel HPS6 missense variant. Am J Med Genet A. 2018Oct 4:e40514. doi: 10.1002/ajmg.a.40514.
- Moore C, Palau VE, Mahboob R, Lightner J, Stone W, Krishnan K. Upregulation of pERK and c-JUN by γ-tocotrienolandnotα-tocopherolare essential to the differential effect on apoptosis in prostate cancer cells. BMC Cancer. 2020 May15;20(1):428. doi: 10.1186/s12885-020-06947-6.PMID: 32414345.
- Manthri S, Costello PN, Krishnan K. Chronic mast cell leukaemia with exon 9 KIT mutation A502_Y503dup: a rare imatinib responsive variant.BMJ Case Rep. 2020 Aug 24;13(8):e236447. doi: 10.1136/bcr-2020-236447.PMID: 32843387.
- Fatima Z, Sharma P, Youssef B, Krishnan K. Medullary Carcinoma of the Colon: A Histopathological Challenge. Cureus, June 2021 13(6): e15831. DOI 10.7759/cureus.15831
- Sharma P, Singhal S, Costello P, Krishnan K. Burkitt Lymphoma-interpreting FISH testing for MYC gene rearrangements. BMJ Case Reports. 2022.
- Cartwright BM, Corso JN, Lightner J, Whitted C, Torrenegra RD, Krishnan K, Palau VE. Achyrocline B (3,5 dihydroxy-6,7,8-trimethoxyflavone) synergizes with 5-fluorouracil allowing for dose reduction and reduced off-target toxicity in the treatment of colonic and pancreatic cancers. Biomed Pharmacother. 2023 Sep 21;167:115546. doi: 10.1016/j.biopha.2023.115546. PMID: 37741250
- Dada SN, Babanyinah GK, Tetteh MT, Palau VE, Walls ZF, Krishnan K, Croft Z, Khan AU, Liu G, Wiese TE, Glotser E, Mei H. Covalent and Noncovalent Loading of Doxorubicin by Folic Acid-Carbon Dot Nanoparticles for Cancer Theranostics.ACS Omega. 2022 Jun 24;7(27):23322-23331. doi: 10.1021/acsomega.2c01482. 2016
- Koyamangalath Krishnan. Fast Five Quiz: Paroxysmal Nocturnal Hemoglobinuria Presentation and Diagnosis - Medscape - Jan 05, 2024.
- PGI Textbook ofClinical and Laboratory Hematology:First edition, Eds. Chief Editors Krishnan K, Dasgupta A, DalalB, Malhotra P, Varma N, Varma S. Bhalani Medical Publishers, Mumbai, India, released Fall 2023.
- Krishnan K, Ruffin IV, MT, Brenner DE.Aspirin and other prostaglandin inhibitors forthe prevention of colon cancer. Infusion Chemotherapy-Irradiation Interactions: itsbiology and significance for organ salvage and prevention of second primaryneoplasms. Elsevier Science B. V Publishing, 1998. 38: 405-422.
- Cheema M, Cody R, Krishnan K. Paraneoplastic ocular syndromes. Textbook of Ophthalmology (IV volume), Jaypee Brothers Medical Publishers, India, 2002.2060-2066.
- Stone WL, Papas A, Krishnan K.Oxidants and Antioxidants in the Pathology ofColon Cancer. Redox Genome Interactions in Health and Disease. Published byMarcel Dekker, NY, ISBN 0-8247-4048-3, 2003.
- William L . Stone, K . Krishnan, Andreas M . Papas: Chapter 22. Oxidants and Antioxidants in the Pathology of Colon Cancer. Redox-Genome Interactions in Health and Disease, First edited by Lester Packer, Maurizio Podda, and Jürgen Fuchs, 01/2004: chapter Oxidants and Antioxidants in the Pathology of Colon Cancer: pages497-512; CRC Press., ISBN: 978-0-8247-4048-1.
- Krishnan K, Campbell SC, Stone WL. Overview of tocopherols in cancer chemo prevention. The Encyclopedia of Vitamin E. CABI Publishing, Oxford, UK,2006.
- W.L. Stone, V.P. Ramsauer, S.E. Campbell, K. Krishnan: Chapter: Targeted Prostate Cancer Chemoprevention Trialwith Tocotrienols. pages: 101-115.2012. ISBN: 978-1-4398--8441-6. Tocotrienols: Vitamin E Beyond Tocopherols, Second edited by B. Tan, R. R. Watson,
- William L. Stone, Sharon E. Campbell, Koyamangalath Krishnan: The Role of Vitamin E in Prostate Cancer. Oxidative Stress in Cancer Biology and Therapy, Edited by Spitz, Dornfeld, Krishnan, Gius, 01/2012: chapter: The Role of Vitamin E in Prostate Cancer: pages 333-356; Humana Press., ISBN: ISBN 978-1-61779-397-4.
- William L. Stone, Yu Lin Jiang, Christopher McGoldrick, Marianne Brannon and Koyamangalath Krishnan. The Design, Synthesis and In Vitro Evaluation of a Novel. Pro-Oxidant Anticancer Prodrug Substrate Targeted to Acylamino-Acid-Releasing Enzyme. In: Free Radicals: The role of Antioxidants and Prooxidants in Cancer Development. Editors: William Stone, NOVA publishers 2014.
- Sharon E. Campbell, Aashish S. Morani, William L. Stone, Koyamangalath Krishnan, Victoria E. Palau: Vitamin E Isoforms: Multiple Mechanisms of Action against Carcinogenesis. Free Radicals: The Role of Antioxidants and Pro-oxidants in Cancer Development, Edition: 1, 1 edited by Bill Stone, 01/2014: chapter Vitamin E Isoforms: Multiple Mechanisms of Action against Carcinogenesis; Nova Science Publishers. ISBN: 978-1-63117-177-2.
- Kanishka Chakraborty, Victoria Palau, William Stone, Koyamangalath Krishnan: Tocotrienols in Pancreatic Cancer Treatment and Prevention. CANCER: OXIDATIVESTRESS AND DIETARY ANTIOXIDANTS, 1st edited by VICTOR PREEDY, 04/2014:chapter 24. Tocotrienols in Pancreatic Cancer Treatment and Prevention: pages 247-254; Elsevier, Academic Press. ISBN: 978-0-12-405205-5.
- Stone WL, Palau V, Krishnan K.A Systems Medicine Approach to the role of vitamins in protecting the Gastrointestinal Tract from Oxidative Stress. In Gastrointestinal Tissue: Oxidative Stress and Dietary Antioxidants. Edited by: Jordi Gracia-Sancho, PhD (Institute for Biomedical Research IDIBAPS - Hospital Clinic de Barcelona) and Prof. M Josepa Salvadó, PhD (Department of Biochemistry andBiotechnology, Rovira i Virgili University). Published by Elsevier Inc. Invited Chapter,May 2017, ISBN: 978-0-12-805377-5.
- Stone WL, Palau VE, Krishnan K.Prodrugs for Cancer Treatment. Chapter 8, In Recent Advancement in Prodrugs. Eds. K. Shah, D.N. Chauhan, N.S. Chauhan, P. Mishra. Lumina Datamatics, Puducherry, India, CRC Press,Taylor and Francis Ltd,22 May 2020
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