Dr. Laura Gabriela SARBU is currently an Associate Professor in the Department of Chemistry at Alexandru Ioan Cuza University of Iasi, Romania. She received a Ph.D. degree in Organic Chemistry in 2015. During the Ph.D. program she joined several times the Prof. dr. Henning Hopf research team in TU Braunschweig – Germany. She has more than 55 publications in peer-review journals and published 4 books. Also, is editorial board member in 25+ journals such as Advance in Medical and Clinical Research, Annals of Clinical and Laboratory Recerca, Chemical Glycobiology Journal, International Journal Bioorganic and Medicinal Chemistry, Journal of Biomedical Research & Environmental Sciences - Green Chemistry, Journal of Molecular Biology and Drug Design.

• Organic Synthesis
• Synthetic Drugs
• Drug Design and Development
• Cyclophanes
• Flavonoids
• Sulfur Compounds

• Sarbu, L. G.; Birsa, A.; Ignat, L.; Hopf, H.; Birsa, M. L., “[2.2]Paracyclophanes: The Interaction of Pseudo-Geminal Bisacetylene with Water and Electrophiles”, Acta Chem. Iasi, 2010, 18, 71-78.
• Sarbu, L. G.*; Birsa, A.; Hopf, H.; Birsa, M. L., “Heteroatom Bridged[2.2]Paracyclophanes As Enediyne Analogs”, Acta Chem. Iasi, 2010, 18, 186.
• Sarbu, L. G.; Birsa, M. L., “Synthesis of Iodine Containing Mesoionic 2-(1,3-Dithiolium)phenolates”, Acta Chem. Iasi, 2011, 19 (2), 125-135.
• Sarbu, L. G.; Birsa, A.; Hopf, H.; Birsa, M. L., “New Bridges In [2.2]Paracyclophanes: The Interaction Of Chalcogenide Halides With Pseudo-Geminal Triple Bonds”, Phosphorus, Sulfur, and Silicon, and the Related Elements 2011, 186 (5), 1246-1250. http://dx.doi.org/10.1080/10426507.2010.524177
• Sarbu, L. G.; Hrib, C. G.; Birsa, M. L., “rac-1-(5-Bromo-2-hydroxyphenyl)-1-oxopropan-2-yl morpholine-4-carbodithioate”, Acta Cryst., 2013, E69, o1169.
• Sarbu, L. G.; Bahrin, L. G., “3-Methylpiperidinyl Carbodithioates as Building Blocks for 1,3-Dithiolium Derivatives”, Acta Chem. Iasi, 2013, 21, 47-56.
• Sarbu, L. G.; Lungu, N. C.; Forna, N. C.; Birsa, M. L., “Synthesis of 4-(2-hydroxyphenyl)-2-dialkylamino-1,3-dithiolium Salts and Corresponding Mesoionic Derivatives”, Rev. Chim. (Bucharest), 2013, 64 (12), 1404.
• Sarbu, L. G.; Bîcu, E.; Belei, D., “Synthesis of Mesoionic [2-(10H-phenothiazinyl)-1,3-dithiolium]phenolates”, Rev. Chim., 2014, 65 (2), 249.
• Sarbu, L. G.; Lungu, C. N.; Asaftei, I. V.; Sandu, I.; Birsa, L. M., “New Evidence for the Mesoionic Characterof 2-(1,3-dithiol-2-ylium)phenolates”, Rev. Chim. (Bucharest), 2014, 65 (3), 325-327.
• Sarbu, L. G.; Bicu, E.; Hopf, H.; Birsa, M. L., “[2.2]Paracyclophane Substituted Indolizines”, Rev. Chim. (Bucharest), 2014, 65 (4), 398-400.
• Bahrin, L. G.; Asaftei, I. V.; Sandu, I.; Sarbu, L. G., “Synthesis of (4-Methylpiperazin-1-yl)carbodithioatesand of their 1,3-Dithiolium Derivatives”, Rev. Chim. (Bucharest), 2014, 65 (9), 1046-1048.
• Sarbu, L. G.; Lungu, C. N.; Balan, A.; Bahrin, L. G., “Synthesis of Sulfur Containing Piperazine Derivatives with Potential Biological Activities”, Rev. Chim. (Bucharest), 2014, 65 (10), 1135-1137.
• Sarbu, L. G.; Apostu, M. O.; Sandu, I.; Bahrin L. G.; Manea. L. R., “1,3-Dithiol-2-ylium Compounds Derived from Substituted Butyrophenone”, Rev. Chim. (Bucharest), 2014, 65 (11), 1327-1331.
• Sarbu, L. G.; Hopf, H.; Jones, P. G.; Birsa, M. L., “Selenium halide-induced bridge formation in [2.2]paracyclophanes”, Beilstein J. Org. Chem., 2014, 10, 2550-2555. http://dx.doi.org/10.3762%2Fbjoc.10.266
• Sarbu, L. G.; Sandu, I.; Bahrin, L. G.; Balan, A.; Apostu, M. O., “New Bromo Substituted 1,3-Dithiol-2-ylium Salts”, Rev. Chim. (Bucharest), 2015, 66 (1), 55.
• Hrib, C. G.; Chirita, P.; Sandu, I. G.; Asaftei,. I. V.; Sarbu, L. G.*; Earar, K., “The Synthesis and X-Ray Structural Characterization of New 4-(5-Bromo-2-hydroxyphenyl)-1,3-Dithiol-2-ylium Perchlorates”, Rev. Chim. (Bucharest), 2015, 66 (7), 983-986.
• Chirita, P.; Hrib, C. G.; Sandu, I.; Lungu, N. C.; Sarbu, L. G.*; Earar, K., “A New Class of 4-(Hydroxyaryl)-1,3-Dithiolium Chlorides”, Rev. Chim. (Bucharest), 2015, 66 (8), 1151-1154.
• Dirtu, D.; Asaftei,. I. V.; Chirita, P.; Sandu, I. G.; Birsa, M. L.; Earar, K.; Sarbu, L. G.*, “Synthesis of 1,3-Dithiol-2-ylium Salts by Functionalization of Some Toluenols”, Rev. Chim. (Bucharest), 2015, 66 (12), 2028.
• Sarbu, L. G.; Hopf, H.; Grunenberg, J.; Birsa, M. L., “Reduction of Pseudo-geminal Bis(ethynyl)-Substituted [2.2]Paracyclophanes”, Synlett, 2015, 26, 87-90. DOI: 10.1055/s-0034-1378935
• Sarbu, L. G.; Bahrin, L. G.; Jones, P. G.; Birsa, M. L.; Hopf, H., “[2.2]Paracyclophane derivatives containing tetrathiafulvalene moieties”, Beilstein J. Org. Chem., 2015, 11, 1917-1921. doi:10.3762/bjoc.11.207
• Dirtu, D.; Lungu, N. C.; Chirita, P.; Sandu, I. G.; Birsa, M. L.; Earar, K.; Sarbu, L. G.*, “Synthesis of Novel 4-(3,5-Dibromo-2-hydroxyphenyl)-5-Methyl-1,3-Dithiol-2-ylidene Derivatives”, Rev. Chim. (Bucharest), 2016, 67 (3), 534-537.
• Asaftei, I. V., Sandu, I. G., Lungu, N. C., Birsa, M. L., Sarbu, L. G., Ignat, M., “Conversion of Butane-Butylene Mixtures over B(Al)-HZSM-5 Catalyst Prepared by Impregnation and over ZnO/HZSM-5 co-Catalyst Prepared by Mechanical Mixing”, Rev. Chim. (Bucharest), 2016, 67 (5), 847-853.
• Bahrin, L. G., Hopf, H., Jones, P. G., Sarbu, L. G., Babii, C., Mihai, A. C., Stefan, M., Birsa, M. L.*, “Antibacterial structure–activity relationship studies of several tricyclic sulfur-containing flavonoids”, Beilstein J. Org. Chem., 2016, 12, 1065-1071. doi:10.3762/bjoc.12.100
• Bahrin, L. G., Sarbu, L. G., Hopf, H., Jones, P. G., Babii, C., Stefan, M., Birsa, M. L.*, “The influence of halogen substituents on the biological properties of sulfur-containing flavonoids”, Bioorg. Med. Chem., 2016, 24 (14), 3166-3173. http://dx.doi.org/10.1016/j.bmc.2016.05.044 DOI: 10.1016/j.bmc.2016.05.044
• Toader, E., Bahrin, L. G., Jones, P. G., Hopf, H., Sarbu, L. G., Stoleriu, G., “Synthesis of New Morpholine Containing Flavonoids with Potential Biological Applications”, Rev. Chim. (Bucharest), 2016, 67 (8), 1520-1522.
• Pavel, S., Hopf, H., Jones, P. G., Asaftei, I. V., Sarbu, L. G., Birsa, L. M., “Click reactions with pseudo-geminal bis(azido-methylene)[2.2]paracyclophane” Monatsh. Chem., 2016, 147 (12), 2179-2183. http://dx.doi.org/10.1007/s00706-016-1842-3
• Asaftei, I.V., Lungu, N. C., Birsa, M. L., Sarbu, L. G., Ignat, M., Sandu, I. G., “Conversion of Light Hydrocarbons from Petroleum Refining Processes Over Zn-HZSM-5 (Nitrate) and Zn-HZSM-5 (Acetate) Catalyst A comparative study”, Rev. Chim. (Bucharest), 2016, 67 (8), 1523-1528.
• Matei, M., Sandu, I., Birsa, M. L., Sarbu, L. G., Simion, L., “New 4-(4-Hydroxyaryl)-5-Methyl-1,3-Dithiol-2-ylidene Derivatives”, Rev. Chim. (Bucharest), 2017, 68 (1), 81-84.
• Asaftei, I. V., Lungu, N. C., Birsa, L. M., Sandu, I. G., Sarbu, L. G., Ignat, M., “Performance of Ag-HZSM-5 Zeolite Catalysts in n-heptane Conversion”, Rev. Chim. (Bucharest), 2017, 68 (1), 116-120.
• Chirita, P., Asaftei, I. V., Sandu, I., Sarbu, L. G., Lupu, V. V., “Mesoionic 4-(2-Dialkylamino-1,3-dithiol-2-ylium-4-yl)phenolates”, Rev. Chim. (Bucharest), 2017, 68 (1), 147-150.
• Gorodea, I. A., Sandu, I., Sarbu, L. G.*, “Novel 4-(3-Bromo-2-hydroxy-5-methylphenyl)-1,3-Dithiol-2-ylidene Derivatives”, Rev. Chim. (Bucharest), 2017, 68 (9), 1988-1991.
• Bahrin, L. G., Sarbu, L. G., Jones, P. G., Birsa, L. M., Hopf, H., “[2.2]Paracyclophane-Bis(triazole) Systems: Synthesis and Photochemical Behavior”, Chem. Eur. J., 2017, 23 (50), 12338-12345. DOI: 10.1002/chem.201701593
• Babii, C., Mihalache, G., Bahrin, L. G., Neagu, A. N., Gostin, I., Mihai, C. T., Sarbu, L. G., Birsa, L. M., Stefan, M., “A novel synthetic flavonoid with potent antibacterial properties: In vitro activity and proposed mode of action”, PLoS One, 2018, 13 (4), 1-15. DOI: 10.1371/journal.pone.0194898
• Meziere, C., Allain, M., Oliveras-Gonzalez, C., Cauchy, T., Vanthuyne, N., Sarbu, L. G., Birsa, L. M., Pop, F., Avarvari, N., “Tetrathiafulvalene-[2.2]paracyclophanes: Synthesis, crystal structures, and chiroptical properties”, Chirality, 2018, 30 (5), 568-575. doi: 10.1002/chir.22831
• Chirita, P., Duinea, M. I., Sandu, A. M., Birsa, L. M., Sarbu, L. G., Baibarac, M., Sava, F., Popescu, M., Matei, E., “Inhibitory effect of three phenacyl derivatives on the oxidation of sphalerite (ZnS) in air-equilibrated acidic solution”, Corrosion Science, 2018, 138, 154-162. DOI: 10.1016/j.corsci.2018.04.017
• Lungu, C. N., Sandu, I., Sarbu, L. G.*, “5-Methyl-4-(5-Bromo-2-hydroxyphenyl)-1,3-Dithiolium Derivatives”, Rev. Chim. (Bucharest), 2018, 69 (12), 3549-3552.
• Sarbu, L. G., Lungu, N. C., Sandu, I., “2-Alkylimino-4-(2-Hydroxyaryl)-1,3-Dithiols Derivatives”, Rev. Chim. (Bucharest), 2019, 70 (3), 745-748.
• Sarbu, L. G., Lungu, N. C., Sandu, I., Chirita, P., Bahrin, L. G., “Synthesis of 2-Pyrrolydinyl-1,3-Dithiolium Derivatives from Propiophenones”, Rev. Chim. (Bucharest), 2019, 70 (4), 1311-1314.
• Sarbu, L. G., Bahrin, L. G., Babii, C., Stefan, M., Birsa, M. L., “Synthetic flavonoids with antimicrobial activity: a review”, J. App. Microbiol., 2019, 127 (5), 1282-1290. DOI:10.1111/jam.14271
• Sarbu, L. G., Shova, S., Peptanariu, D., Sandu, I. A., Birsa, L. M., Bahrin, L. G., “The Cytotoxic Properties of Some Tricyclic 1,3-Dithiolium Flavonoids”, Molecules, 2019, 24 (13), 1-12. DOI 10.3390/molecules24132459
• Duinea. M. I., Carac, G., Dabuleanu, I. D., Petcu, M. A., Sarbu, L. G., Birsa, M. L., Reiss, A., Chirita, P., “Troilite (FeS) Oxidation in the Presence of a Newly Synthesized TRIS-based Base”, Rev. Chim. (Bucharest), 2019, 70 (7), 2639-2642.
• Sarbu, L. G., Bahrin, L. G., Hopf, H., Birsa, L. M., „Chalchogenide induced intramolecular interactions in [2.2]paracyclophanes: a review“, Studia Chem., 2019, 64 (3), 7-16. DOI: 10.24193/subbchem.2019.3.01
• Sarbu, L. G., Hopf, H., Jones, P. G., Bahrin, L. G., Birsa, M. L., „Methylamine-induced ring opening of 1,3-dithiolium cations “, Arkivoc, 2019, 4, 174-179. DOI: https://doi.org/10.24820/ark.5550190.p011.064
• Chirita, P., Duinea, M. I., Sarbu, L. G., Birsa, M. L., Baibarac, M., Sava, F., Matei, E., “Oxidation of chalcopyrite in air-equilibrated acidic solution: inhibition with phenacyl derivatives” Trans. Nonferrous Met. Soc. China, 2020, 30, 1928-1942. DOI: 10.1016/S1003-6326(20)65351-1
• Bahrin, L. G., Hopf, H., Jones, P. G., Birsa, M. L., Sarbu, L. G.*, “An Approach to Paracyclophane-Based Tetrathiafulvalenes: Synthesis and Characterization of a Pseudo-Geminal [2.2]Paracyclophane 1,3-Dithia-2-Thione” Molecules, 2020, 25 (22), 5262. DOI: 10.3390/molecules25225262
• Bahrin, L. G., Nicolescu, A., Shova, S., Marangoci, N. L., Birsa, M. L., Sarbu, L. G.*, “Nitrogen-Based Linkers with a Mesitylene Core: Synthesis and Characterization” Molecules, 2021, 26 (19), 5952. https://doi.org/10.3390/molecules26195952
• Babii, C., Savu, M., Motrescu, I., Birsa, M. L., Sarbu, L. G., Stefan, M., “Antibacterial synthetic flavonoid BrCl-flav exhibits important anti-Candida activity by damaging cell membrane integrity” Pharmaceuticals, 2021, 14, 1130. DOI 10.3390/ph14111130
• Moldovan, C. V., Savu, M., Dussert, E., Aboubacar, H., Sarbu, L. G., Matiut, S., Cudennec, B., Krier, F., Ravallec, R., Birsa, M. L., Stefan, M., "Synthetic Flavonoid BrCl-Flav-An Alternative Solution to Combat ESKAPE Pathogens", Antibiotics (Basel), 11, 1389 (2022). doi: 10.3390/antibiotics11101389
• Birsa, M. L., Sarbu, L.G., "An Improved Synthetic Method for Sensitive Iodine Containing Tricyclic Flavonoids", Molecules, 27, 8430 (2022).
• Birsa, M. L., Sarbu, L. G.*, Hydroxy Chalcones and Analogs with Chemopreventive Properties, International Journal of Molecular Sciences, 2023, 24 (13), 10667.
• Birsa, M. L., Hopf, H., Jones, P. G., Sarbu, L. G.*, Bahrin, L. G., [2.2]Paracyclophane Derivatives as Building Blocks for Coordination Polymers, Materials, 2023, 16 (11), 4051.
• Birsa, M. L., Sarbu, L. G.*, Health Benefits of Key Constituents in Cichorium intybus L., Nutrients, 2023, 15 (6), 1322.

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