Editor Profile
Dr. Fankai Xiao, M.D., Ph.D.
Associate Professor
Present
The First Affiliated Hospital of Zhengzhou University
Zhengzhou
China
Dr. Fankai Xiao, M.D., Ph.D.
Associate Professor, Attending Physician, Department of Oncology, First Affiliated Hospital of Zhengzhou University
EDUCATION
09/2008 - 07/2013 - BMed (M.D. equivalent in US), Tianjin medical University, Tianjin, China
09/2013 - 02/2015 - M.Sc. (major in cancer cell and molecular biology), University of Leicester, Leicester, UK
09/2015 - 07/2019 07– Joint Ph.D. (major in oncology), Zhengzhou university, Zhengzhou China& Medical college of Wisconsin, Wisconsin, US
POSTGRADUATE TRAINING AND FACULTY APPOINTMENTS
09/2016 – 09/2018–Research Assistant, Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, US
09/2019 - Present - Research Associate, attending physician, Department of oncology, first affiliated hospital of Zhengzhou University, Zhengzhou
08/2024- Present - Postdoctoral Research Associate, Oncology, Zhengzhou University &Chinese Academy of Sciences.
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES
Editor memberof‘World Journal of Gastrointestinal Oncology’ (SCI)
Young scientist editor of‘gastrointestinal tumors (ESCI)
Young scientist editor of Heart and Mind (ESCI)
Reviewer memberof‘Medicine’ (SCI)
Reviewer member of Scientificreports(SCI)
Reviewer memberof Discovery Medicine (SCI)
COMMITTEE SERVICE
Committee member of‘Tumor Cell Professional Committee of Henan Society of Cell Biology’
Committee member of ‘Behavioral Medicine Branch of Henan Medical Association’
Committee member of’ Hypertension Branch of Henan Medical Association’
RESEARCH INTERESTS
Human genome/epigenome variations and cancers, cancer biology, bioinformatics, focusing on biomarker study for personalized medicine through large scale RNA/DNA sequencing analysis.
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS
Youth Foundation of Henan Scientific Committee (202300410416) Role: Principal Investigator
Henan province medical science, technology breakthrough plan project (LHGJ20190033)Role: Principal Investigator
Henan Scientific and technological project (212102310797) Role:Co-Investigator
National Institute of Health (R01 CA157881) Role: Faculty Participants (US)
863 High-tech Key Projects (2012AA02A503, 2012AA02A209 and 2012AA02A201)Role: Faculty Participants
National Natural Science Foundations of China (30971133, 81071783)Role: Faculty Participants
National High-Tech Research and Development Program of China (SQ2015AA0202183)Role: Faculty Participants
Henan Soft Science Research Plan project (242400410409)Role: Faculty Participants
Henan Medical Science and technology research project (2018020537)Role: Faculty Participants
Top Talent Support Project of Zhengzhou University (ZDGD 13001)Role: Faculty Participants
Innovation Scientists and Technicians Troop Construction Projects of Henan Province (Grant No. 3047)Role: Faculty Participants
- Human genome/epigenome variations and cancers
- Cancer biology
- Bioinformatics
- Focusing on biomarker study for personalized medicine through large scale RNA/DNA sequencing analysis
- Xiao F, Zhang P, Wang Y, Tian Y, James M, Huang CC, Wang L, Wang L. Single-nucleotide polymorphism rs13426236 contributes to an increased prostate cancer risk via regulating MLPH splicing variant 4. Mol Carcinog. 2020 Jan;59(1):45-55. doi: 10.1002/mc.23127. Epub 2019 Oct 29. PMID: 31659808; PMCID: PMC7219604.
- Xiao FK, Wang L, Zhang WC, Wang LD, Zhao LS. Preoperative Prognostic Nutritional Index is a Significant Predictor of Survival in Esophageal Squamous Cell Carcinoma Patients. Nutr Cancer. 2021;73(2):215-220. doi: 10.1080/01635581.2020.1757129. Epub 2020 Apr 25. PMID: 32336142.
- Xiao FK, Yang JX, Li XM, Zhao XK, Zheng PY, Wang LD. Interaction of 22 risk SNPs with Helicobacter pylori infection and risk of gastric cardia adenocarcinoma. Future Oncol. 2019 Nov;15(31):3579-3585. doi: 10.2217/fon-2019-0319. Epub 2019 Oct 25. PMID: 31650851.
- Xiao FK, Li P, Han ZY, Jing L, Hua S, Zhao LS. Patients with Dipper and Nondipper High-Normal Blood Pressure Were Associated with Left Ventricular Mass. Int J Hypertens. 2021 Dec 21;2021:6946418. doi: 10.1155/2021/6946418. PMID: 35070446; PMCID: PMC8769863.
- Xiao FK, Guo S, Yang F, Zhao LS, Wang LD. MDM2 and its functional polymorphism SNP309 contribute to the development of esophageal carcinoma. J Gene Med. 2019 May;21(5):e3086. doi: 10.1002/jgm.3086. Epub 2019 Apr 8. PMID: 30861607.
- Xiao FK, Wang L. Comprehensive Analysis of Expression and Pathway for CD27 in Esophageal Cancer. Mol Biotechnol. 2023 Aug 16. doi: 10.1007/s12033-023-00850-8. Epub ahead of print. PMID: 37584826.
- Xiao FK, Li P, Li XM, Mi Y. MEX3A promotes hepatocellular carcinoma cell proliferation and migration via the Wnt/β-catenin and EMT pathways. World J Gastrointest Oncol 2025; 17(10): 106410 [DOI: 10.4251/wjgo.v17.i10.106410]
- Li P, Wang L, Yang F, Yu H, Xiao FK. Association of ST2, Galectin-3, and NT- Probnp in Elderly Hypertensive Patients and Heart Failure with a Preserved Ejection Fraction. Current Vascular Pharmacology. 2025 Jan. DOI: 10.2174/0115701611315697241230075727. PMID: 39865803.
- Yang D, Li Y, Ma P, Xiao F. Integrated analysis of ARHGAP6 potential function and prognostic value in acute myeloid leukemia. PLoS One. 2025 Oct 7;20(10):e0333409. doi: 10.1371/journal.pone.0333409. PMID: 41056221; PMCID: PMC12503237.
- Xiao FK, Li P, Li XM, Mi Y. MEX3A promotes hepatocellular carcinoma cell proliferation and migration via the Wnt/β-catenin and EMT pathways. World J Gastrointest Oncol. 2025 Oct 15;17(10):106410. doi: 10.4251/wjgo.v17.i10.106410. PMID: 41114094; PMCID: PMC12531806.
- Mi, Y., Dong, M., Zuo, X., Cao, Q., Gu, X., Mi, H & Xiao, F. (2024). Genome-wide identification and analysis of epithelial-mesenchymal transition-related RNA-binding proteins and alternative splicing in a human breast cancer cell line. Scientific Reports, 14(1), 11753.
- Guo S, Liu Y, Gao L, Xiao F, Shen J, Xing S, Yang F, Zhang W, Shi Q, Li Y, Zhao L. TBC1D25 Regulates Cardiac Remodeling Through TAK1 Signaling Pathway. Int J Biol Sci. 2020 Feb 21;16(8):1335-1348. doi: 10.7150/ijbs.41130. PMID: 32210723; PMCID: PMC7085222.
- Wei MX, Lei LL, Xu RH, Liu YX, Wang R, Han WL, Fan ZM, Xiao FK, Sheyhidin I, Ma L, Ku JW, Yin MZ, Ji AF, Bao QD, Gao SG, Han XN, Li XM, Chen PN, Zhao XK, Song X, Wang LD. Ethnic genomic differences in esophageal squamous cell carcinoma: Whole-exome sequencing of Han and Kazakh populations in China. World J Gastroenterol. 2025 Dec 14;31(46):112664. doi: 10.3748/wjg.v31.i46.112664. PMID: 41479646; PMCID: PMC12754140.
- Wang L D, Ding Q Q & Xiao FK,etal. Clinical pathological characteristics and expression of 328 proteins and their impact on survival in over 20,000 cases of esophageal squamous cell carcinoma and colorectal adenocarcinoma[J]. Ke Xue Tong Bao, 2024, 59(5): 593-597.
