Dr. Tiezhu Liu, Ph.D.

Associate Research Fellow, Chinese Center for Disease Control and Prevention (China CDC)

MPH Supervisor | Visiting Scholar (Designate), University of California, Los Angeles (UCLA)

Key Roles

• Deputy Leader, 7th China CDC Expert Team Aiding Sierra Leone
• Member, Chinese Government Expert Team for Post-Earthquake Health and Epidemic Prevention in Myanmar
• Youth Editorial Board Member, Journal of Zunyi Medical University
• Outstanding Reviewer: Virologica Sinica, Chinese Journal of Experimental and Clinical Virology

Education & Career

• M.S. in Pathogen Biology, China CDC (2016)
• Ph.D. in Immunology, China CDC (2019)
• Associate Research Fellow, Institute for Viral Disease Control, China CDC (Aug 2019–Present)

• Infection Mechanisms and Prognostic Biomarkers of Dabie Bandavirus

• Tiezhu Liu, Jiajia Li, Xueqi Wang, Tao Huang, Wei Wu, Aqian Li, Chuan Li, Xiaoxia Huang, Qin Wang, Dexin Li, Shiwen Wang*, Mifang Liang*，Knockout of CLTC gene reduces but not completely block SFTSV infection(2023). PLoS One 18(8): e0285673.
• Tiezhu Liu, Tao Huang, Jiajia Li, Aqian Li, Chuan Li, Xiaoxia Huang, Dexin Li, Shiwen Wang*, Mifang Liang* Optimization of differentiation and transcriptomic profile of THP-1 cells into macrophage by PMA (2023). PLoS One 18(7): e0286056.
• Tiezhu Liu,Fuzhen Wang, Shuang Zhang, Feng Wang, Qingling Meng, Guomin Zhang, Fuqiang Cui, Dorji Dunzhu,Wenjiao Yin, Shengli Bi, Liping Shen*, (2017) Whole-gene analysis of two groups of hepatitis B virus C/D inter-genotype recombinant strains isolated in Tibet, China. PLoS One (2017) 12(6): e0179846.
• Tiezhu Liu, Jiajia Li, Yang Liu, Yuanyuan Qu, Aqian Li, Chuan Li, Quanfu Zhang, Wei Wu, Jiandong Li, Yan Liu, Dexin Li, Shiwen Wang*, Mifang Liang*, 2019, SNX11 Identified as an Essential Host Factor for SFTS Virus Infection by CRISPR Knockout Screening, Virologica Sinica (2019) 34:508–520.
• Tiezhu Liu, Xueqi Wang, Yang Fang, Ping Zhang, Qiang Sun, Jiandong Li,* and Shiwen Wang,* SNX11 Deletion Inhibits Dabie bandavirus Infection by Interfering with the Assembly of V-ATPase，Pathogens 2025, 14, 677.
• Tao Huang, Xueqi Wang, Yuqian Mi, Wei Wu, Xiao Xu, Chuan Li, Yanhan Wen, Boyang Li, Yang Li, Lina, Sun, Jiandong Li, Mengxuan Wang, Tiezhu Liu*, Shiwen Wang*, Mifang Liang*. Time-Course Transcriptome Analysis Reveals Distinct Phases and Identifies Two Key Genes during Severe Fever with Thrombocytopenia Syndrome Virus Infection in PMA-Induced THP-1 Cells. Viruses 2024, 16, 59.
• Minghao Geng, Xueqi Wang, Yamei Wei, Yan Li, Yanan Cai, Jiandong Li, Caixiao Jiang,Xinyang Zhang, Wentao Wu, Nana Guo, Guangyue Han, Xu Han, Tiezhu Liu*, Qi Li* and Shiwen Wang*, Identiffcation of a Novel Genotype of Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) in Northern Hebei Province, China. Viruses 2025, 17, 1534.
• Feiran Wang,Tiezhu Liu, Liying Liao, Yan Chai, Jianxun Qi, Feng Gao, Mifang Liang*, George Gao*, and Yan Wu* Molecular insight into the neutralization mechanism of human-origin monoclonal antibody AH100 against Hantaan virus, J Virol. 2024 Aug 20;98(8):e0088324.
• 刘铁柱，黄涛，李阿茜，李川，梁米芳，王世文，基于慢病毒包装和CRISPR技术建立病毒感染关键基因CLTC敲除细胞系病毒学报 2023，39（3）：800-804.
• 刘铁柱，沈立萍，尹文娇，王锋，王富珍，张国民，郑徽，顿珠多吉，张爽，毕胜利，崔富强，西藏部分地区12株藏族人群C/D重组型乙肝病毒全基因序列分析病毒学报 2016，32（2）：156-160.
• 刘铁柱，李阿茜，李川，梁米芳，王世文，基于CRISPR/Cas9 系统建立SNX11 基因敲除A549 细胞系病毒学报 2022，38（3）：652-657.
• 刘铁柱，李建东，马尔堡病毒病原学和诊断方法的研究进展中国热带医学杂志 2022，22（5）：1-6.
• 刘铁柱，李阿茜，李乃哲，曲园园，李川，张全福，刘洋，李德新，梁米芳，王世文，基于CRISPR/Cas９文库筛选的慢病毒库包装方法研究中华实验和临床病毒学杂志 2019，33（2）：207-211.
• 刘铁柱，梁米芳，王世文，SFTSV感染周期和抗病毒药物的研究进展中华实验和临床病毒学杂志 2022，36（3）：391-396.
• 刘铁柱，李建东，登革热病原学和实验室检测技术研究进展病毒学报，2024，40（3）：589-597.
• 刘铁柱，李建东，奥罗普切热：一个潜在全球卫生安全威胁？病毒学报，2024，40（5）：1105-1110.
• 刘铁柱，李建东，王世文，登革热疫苗研究进展病毒学报，2025，41（2），592-598.
• 王雪琪，王世文，刘铁柱*，李颀*，2018—2024 年北京市某儿童医院普通外科住院疾病谱分析中华实验和临床病毒学杂志 2025,Vol. 39（1）：59-63.
• 王雪琪，刘铁柱*，苏秋东*，儿童外科住院患者乙型肝炎血清学特征分析中华实验和临床病毒学杂志 2025年10月第39卷第 5 期，588-591.

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