Dr. Yinuo Li is a research fellow in the Department of Radiation Oncology and the Proton Beam Therapy Center at the University of Tsukuba Hospital, Japan. She received her MD degree from Shandong First Medical University and earned her PhD in Radiation Oncology from the University of Tsukuba. Her academic background combines clinical medicine with translational cancer research, with particular expertise in radiation oncology, proton beam therapy, and boron neutron capture therapy (BNCT). Her research has focused on improving the efficacy and safety of cancer treatment through high-precision radiotherapy and interdisciplinary strategies integrating molecular biology, nanomaterials, and drug delivery systems. She has been involved in studies on pediatric tumors, brain tumors, and advanced local treatment approaches aimed at enhancing tumor control while minimizing normal tissue toxicity.

• Radiation Oncology
• Proton Beam Therapy
• Boron Neutron Capture Therapy (BNCT)
• Radiosensitization Strategies
• Precision Medicine in Oncology

• Li, Y., Mizumoto, M., Oshiro, Y., Maruo, K., Inaba, K., Saito, T., Hosaka, S., Iizumi, T., Fukushima, H., Suzuki, R., Nitta, H., Shimizu, S., Nakai, K., & Sakurai, H. (2025). Systematic review and meta-analysis of proton beam therapy versus photon radiotherapy for medulloblastoma: TRP-Medulloblastoma 2025. Cancers, 17(13), 2191.
• Li, Y., Mizumoto, M., Nitta, H., et al. (2024). Late changes in renal volume and function after proton beam therapy in pediatric and adult patients: Children show significant renal atrophy, but in both groups deterioration of renal function is minimal in the long-term. Cancers. https://doi.org/10.3390/cancers16091634 (doi.org in Bing)
• Li, Y., Mizumoto, M., Oshiro, Y., et al. (2023). A retrospective study of renal growth changes after proton beam therapy for pediatric malignant tumor. Current Oncology. https://doi.org/10.3390/curroncol30020120 (doi.org in Bing)
• Li, Y., Matsumoto, Y., Chen, L., et al. (2023). Smart nanofiber mesh with locally sustained drug release enabled synergistic combination therapy for glioblastoma. Nanomaterials (Basel). https://doi.org/10.3390/nano13030414 (doi.org in Bing)
• Li, Y., Shimizu, S., et al. (2022). Proton beam therapy for multifocal hepatocellular carcinoma (HCC) showing complete response in pathological anatomy after liver transplantation. Cureus. https://doi.org/10.7759/cureus.25744 (doi.org in Bing)
• Nakamura, M., Mizumoto, M., Saito, T., Shimizu, S., Li, Y., et al. (2024). A systematic review and meta-analysis of radiotherapy and particle beam therapy for skull base chondrosarcoma: TRP-Chondrosarcoma 2024. Frontiers in Oncology. https://doi.org/10.3389/fonc.2024.1380716 (doi.org in Bing)
• Nitta, H., Mizumoto, M., Li, Y., Oshiro, Y., et al. (2024). An analysis of muscle growth after proton beam therapy for pediatric cancer. Journal of Radiation Research. https://doi.org/10.1093/jrr/rrad105 (doi.org in Bing)
• Niitsu, H., Mizumoto, M., Li, Y., Nakamura, M., et al. (2024). Tumor response on diagnostic imaging after proton beam therapy for hepatocellular carcinoma. Cancers. https://doi.org/10.3390/cancers16020357 (doi.org in Bing)
• Jin, Y., Shimizu, S., Li, Y., Yao, Y., et al. (2023). Proton therapy (PT) combined with concurrent chemotherapy for locally advanced non-small cell lung cancer with negative driver genes. Radiation Oncology. https://doi.org/10.1186/s13014-023-02372-8 (doi.org in Bing)
• Shimizu, S., Nakai, K., Li, Y., et al. (2023). Boron neutron capture therapy for recurrent glioblastoma multiforme: Imaging evaluation of a case with long-term local control and survival. Cureus. https://doi.org/10.7759/cureus.33898 (doi.org in Bing)
• Kumada, H., Li, Y., Yasuoka, K., et al. (2022). Current development status of iBNCT001, demonstrator of a LINAC-based neutron source for BNCT. Journal of Neutron Research. https://doi.org/10.3233/JNR-220029
• Shimizu, S., Mizumoto, M., Okumura, T., Li, Y., et al. (2021). Proton beam therapy for a giant hepatic hemangioma: A case report and literature review. Clinical and Translational Radiation Oncology. https://doi.org/10.1016/j.ctro.2021.01.014
• Nitta, H., Mizumoto, M., Maruo, K., Oshiro, Y., Li, Y., Inaba, M., Saito, T., Hosaka, S., Iizumi, T., Fukushima, H., Suzuki, R., Shimizu, S., Nakai, K., & Sakurai, H. (2026). Proton beam therapy versus photon radiotherapy for pediatric neuroblastoma: A systematic review and meta-analysis (TRP-2025 Neuroblastoma). Cancer Medicine, 15(3), e71701.
• Hosaka, S., Mizumoto, M., Fukushima, H., Iizumi, T., Saito, T., Inaba, M., Suzuki, R., Li, Y., Nakai, K., Shimizu, S., Oshiro, Y., Maruo, K., Takada, H., & Sakurai, H. (2025). A systematic review and meta-analysis of x-ray therapy versus proton beam therapy for pediatric central nervous system germ cell tumors: TRP-Germinoma 2025. International Journal of Clinical Oncology, 30, 1906–1915.
• Niitsu, H., Mizumoto, M., Li, Y., Sumiya, T., Baba, K., Murakami, M., Nakamura, M., Ishida, T., Iizumi, T., Saito, T., Numajiri, H., Makishima, H., Nakai, K., Oshiro, Y., & Sakurai, H. (2025). Tumor shrinkage after simultaneous proton therapy for multiple hepatocellular carcinomas. Journal of Radiation Research, rraf044.
• Muyasha, A., Dai, S., Ebara, M., Sugawara, Y., Li, Y., Sakurai, H., & Matsumoto, Y. (2025). Current research trends and hotspots in radiotherapy combined with nanomaterials for cancer treatment: A bibliometric and visualization analysis. Nanomaterials, 15(15), 1205.
• Mizumoto, M., Oshiro, Y., Maruo, K., Li, Y., Harada, M., Niitsu, H., Ishida, T., Sumiya, T., Baba, K., Murakami, M., Nakamura, M., Iizumi, T., Saito, T., Numajiri, H., Nakai, K., & Sakurai, H. (2025). Role of particle therapy for intrahepatic cholangiocarcinoma; meta-analysis for comparison with standard therapy: TRP-Intrahepatic cholangiocarcinoma 2025. Liver Cancer, 15(1), 135–148.
• Fukushima, H., Mizumoto, M., Hosaka, S., Li, Y., Maruo, K., Oshiro, Y., Nitta, H., Iizumi, T., Saito, T., Inaba, M., Suzuki, R., Nakai, K., Shimizu, S., & Sakurai, H. (2025). Systematic review and meta-analysis of photon radiotherapy versus proton beam therapy for pediatric rhabdomyosarcoma: TRP-Rhabdomyosarcoma 2024. International Journal of Clinical Oncology.
• Jin, Y., Dong, N., Shimizu, S., Li, Y., Yao, Y., Qiao, H., Liu, X., Liu, S., Guo, C., & Wang, L. (2025). Hesperidin enhanced anti-breast cancer effect and alleviated cisplatin-induced nephrotoxicity through silk fibroin delivery system. Toxicology and Applied Pharmacology, 495, 117234.
• Han, W., Jin, Y., Wang, J., Zhang, S., Hashimoto, S., Wang, Z., Wang, W., Li, Y., Wang, W., Yang, L., & Shimizu, S. (2024). Proton beam therapy for a rare anaplastic pleomorphic xanthoastrocytoma: Case report and literature review. International Journal of Particle Therapy, 15, 100736.
• Shen, Z., Ge, R., Zhou, D., Jin, Y., Wang, J., Zhang, S., Liu, C., Wang, Z., Wang, W., Li, Y., Wang, W., & Shimizu, S. (2025). Gamma knife radiosurgery for a rare rosette-forming glioneuronal tumor in the brainstem region: A case report and literature review. Medicine, 11, e41869.
• Shen, Z., Mizumoto, M., Oshiro, Y., Jin, Y., Wang, J., Zhang, S., Liu, C., Wang, Z., Wang, W., Li, Y., Wang, W., Zhao, J., & Shimizu, S. (2024). Effective local control of a giant calvarial hemangioma in a child by proton beam therapy: A case report and literature review. Experimental and Therapeutic Medicine, 29(1), 14.
• Mizumoto, M., Hosaka, S., Nakai, K., Li, Y., Oshiro, Y., Iizumi, T., Saito, T., Inaba, M., Fukushima, H., Suzuki, R., Shimizu, S., Maruo, K., & Sakurai, H. (2024). Systematic review and meta-analysis of photon radiotherapy versus proton beam therapy for pediatric intracranial ependymoma: TRP-Ependymoma 2024. Heliyon, 10(22), e40372.
• Bai, J., Muyasha, A., Jin, Y., Wang, J., Zhang, S., Liu, C., Wang, Z., Wang, W., Li, Y., Wang, W., Lu, Y., & Shimizu, S. (2024). Proton beam therapy in a patient with secondary glioblastoma (32 years after postoperative irradiation of medulloblastoma): Case report and literature review. Radiation Oncology, 19, 136.
• Saito, T., Mizumoto, M., Oshiro, Y., Shimizu, S., Li, Y., Nakamura, M., Hosaka, S., Nakai, K., Iizumi, T., Inaba, M., Fukushima, H., Suzuki, R., Maruo, K., & Sakurai, H. (2024). Systematic review and meta-analysis of particle beam therapy versus photon radiotherapy for skull base chordoma: TRP-Chordoma 2024. Cancers, 16(14), 2569.

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