Jiaxin Fan, PostDoc.

The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China.

Email: jiaxin_fan@126.com, fjxmedic@xjtu.edu.cn

EMPLOYMENT AND EDUCATION

07/2025-Current Resident doctor/Research assistant in Neurology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China.

04/2023-06/2025 PostDoc in Neurology, Shaanxi Provincial People’s Hospital, Xi’an, China.

09/2019-03/2023 M.D. in Neurology, Xi’an Jiaotong University, Xi’an, China.

09/2016-06/2019 M.S. in Neurology, Xi’an Jiaotong University, Xi’an, China.

09/2011-07/2016 Bachelor of Medicine in Clinic, Yan’an University, Xi’an, China.

• Experimental study of cerebral ischemia reperfusion/ischemic stroke and aging, focus on the ferroptosis regulatory mechanism based on rat MCAO/R model and cell OGD/R model, exploring the neuroprotective effect of dynorphin A (1-8) and anti-aging effect of erythropoietin.
• Genetic data analysis of ischemic stroke, identify the genetic biomarkers indicating diagnostic significance and explore their roles in transcriptional regulatory process based on public database.
• Omics study of ischemic stroke, including transcriptomics, metabolomics, proteomics, as well as multi-omics analyses.
• Big data mining and application in Neurology: construct the optimal diagnostic prediction model for asymptomatic atherosclerosis patients based on multiple algorithms.

• Fan J (Jiaxin Fan), Guo X, Cao S, Li R, Zhan S. Development of advanced lung cancer inflammation index-based machine learning models for predicting stroke and mortality: A comparative and interpretable study. Comput Methods Programs Biomed. 2026 Feb;275:109201. doi: 10.1016/j.cmpb.2025.109201. Epub 2025 Dec 3. PMID: 41371087. [IF=4.80 Q2]
• Fan J (Jiaxin Fan), Cao S, Peng H, Zhi Y, Zhan S, Li R. Explainable machine learning-driven models for predicting Parkinson's disease and its prognosis: obesity patterns associations and models development using NHANES 1999-2018 data. Lipids Health Dis. 2025 Jul 17;24(1):241. doi: 10.1186/s12944-025-02664-w. PMID: 40676536; PMCID: PMC12273281. [IF=4.20 Q2]
• Fan J (Jiaxin Fan), Wang Y, Guo X, Cao S, Zhan S, Li R. Association between life's essential 8 and Parkinson's disease: a case-control study. BMC Public Health. 2025 Feb 1;25(1):411. doi: 10.1186/s12889-025-21648-0. PMID: 39893440; PMCID: PMC11786534. [IF=3.60 Q2]
• Fan J (Jiaxin Fan), Chen M, Cao S, Yao Q, Zhang X, Du S, Qu H, Cheng Y, Ma S, Zhang M, Huang Y, Zhang N, Shi K, Zhan S. Identification of a ferroptosis-related gene pair biomarker with immune infiltration landscapes in ischemic stroke: a bioinformatics-based comprehensive study. BMC Genomics. 2022 Jan 16;23(1):59. doi: 10.1186/s12864-022-08295-0. PMID: 35033021; PMCID: PMC8761271. [IF=3.70 Q2]
• Fan J (Jiaxin Fan), Chen M, Luo J, Yang S, Shi J, Yao Q, Zhang X, Du S, Qu H, Cheng Y, Ma S, Zhang M, Xu X, Wang Q, Zhan S. The prediction of asymptomatic carotid atherosclerosis with electronic health records: a comparative study of six machine learning models. BMC Med Inform Decis Mak. 2021 Apr 5;21(1):115. doi: 10.1186/s12911-021-01480-3. PMID: 33820531; PMCID: PMC8020544. [IF=3.80 Q3]
• Zhang X, Fan J (Jiaxin Fan), Ma S, Zhang N, Shi K, Chen M, Duan M, Yao Q, Cheng Y, Du S, Qu H, Yang H, Gao T, Zhan S. Catestatin attenuates cerebral ischemia/reperfusion injury and suppresses endoplasmic reticulum stress. Neuropeptides. 2025 Sep;113:102550. doi: 10.1016/j.npep.2025.102550. Epub 2025 Aug 11. PMID: 40811885. [IF=2.70 Q4]
• Ma S, Zhang X, Fan J (Jiaxin Fan), Chen M, Yao Q, Zhang N, Shi K, Du S, Cheng Y, Qu H, Duan M, Yang H, Gao T, Zhan S. Exosomal circ_0093708 as a potential ferroptosis biomarker in cerebral ischemia-reperfusion injury. Front Neurol. 2025 Aug 1;16:1633393. doi: 10.3389/fneur.2025.1633393. PMID: 40823304; PMCID: PMC12354519. [IF=2.80 Q3]
• Ma S, Zhang X, Fan J (Jiaxin Fan), Chen M, Yao Q, Zhang N, Shi K, Duan M, Yang H, Gao T, Ma X, Wang J, Li W, Zhou C, Zhan S. DUSP1-mediated suppression of p38 MAPK signaling pathway reduces ferroptosis in cerebral ischemia-reperfusion injury. Neurochem Int. 2025 Oct;189:106024. doi: 10.1016/j.neuint.2025.106024. Epub 2025 Jul 31. PMID: 40752646. [IF=4.00 Q3]
• Wang H, Fan J (Jiaxin Fan), Chen M, Yao Q, Gao Z, Zhang G, Wu H, Yu X. rhEPO Enhances Cellular Anti-oxidant Capacity to Protect Long-Term Cultured Aging Primary Nerve Cells. J Mol Neurosci. 2017 Aug;62(3-4):291-303. doi: 10.1007/s12031-017-0937-6. Epub 2017 Jun 21. PMID: 28634693. [IF=2.70 Q4]
• Cao S, Liu H, Fan J (Jiaxin Fan), Yang K, Yang B, Wang J, Li J, Meng L, Li H. An Oxidative Stress-Related Gene Pair (CCNB1/PKD1), Competitive Endogenous RNAs, and Immune-Infiltration Patterns Potentially Regulate Intervertebral Disc Degeneration Development. Front Immunol. 2021 Nov 9;12:765382. doi: 10.3389/fimmu.2021.765382. PMID: 34858418; PMCID: PMC8630707. [IF=5.90 Q2]
• Chen M, Zhang X, Fan J (Jiaxin Fan), Sun H, Yao Q, Shi J, Qu H, Du S, Cheng Y, Ma S, Zhang M, Zhan S. Dynorphin A (1-8) inhibits oxidative stress and apoptosis in MCAO rats, affording neuroprotection through NMDA receptor and κ-opioid receptor channels. Neuropeptides. 2021 3 Oct;89:102182. doi: 10.1016/j.npep.2021.102182. Epub 2021 Jul 16. PMID: 34298371. [IF=2.70 Q4]
• Ren H, Li Y, Liu H, Fan J (Jiaxin Fan), Li J, Li H, Wei H, Meng L, Cao S. A crucial exosome-related gene pair (AAMP and ABAT) is associated with inflammatory cells in intervertebral disc degeneration. Front Immunol. 2023 Apr 14;14:1160801. doi: 10.3389/fimmu.2023.1160801. PMID: 37122729; PMCID: PMC10140513. [IF=5.90 Q2]
• Ma S, Zhang M, Qu H, Cheng Y, Du S, Fan J (Jiaxin Fan), Yao Q, Zhang X, Chen M, Zhang N, Shi K, Huang Y, Zhan S. Combination of High-Density Lipoprotein Cholesterol and Lipoprotein(a) as a Predictor of Collateral Circulation in Patients With Severe Unilateral Internal Carotid Artery Stenosis or Occlusion. J Clin Neurol. 2022 Jan;18(1):14-23. doi: 10.3988/jcn.2022.18.1.14. PMID: 35021272; PMCID: PMC8762497. [IF=3.10 Q4]
• Wu H, Zhao J, Chen M, Wang H, Yao Q, Fan J (Jiaxin Fan), Zhang M. The Anti-Aging Effect of Erythropoietin via the ERK/Nrf2-ARE Pathway in Aging Rats. J Mol Neurosci. 2017 Mar;61(3):449-458. doi: 10.1007/s12031-017-0885-1. Epub 2017 Feb 6. PMID: 28168414. [IF=2.70 Q4]
• Zhang X, Chen M, Yao Q, Zhang N, Fan J (Jiaxin Fan), Shi J, Du S, Qu H, Cheng Y, Ma S, Zhang M, Huang Y, Shi K, Zhan S. Correlation between microalbuminuria and atherosclerotic intracranial and extracranial arterial stenosis in patients with cerebral infarction. J Clin Neurosci. 2022 Jul;101:118-123. doi: 10.1016/j.jocn.2022.05.011. Epub 2022 May 17. PMID: 35594832. [IF=2.12 Q4]
• Qu H, Zhang N, Cheng Y, Du S, Zhang X, Chen M, Fan J (Jiaxin Fan), Yao Q, Ma S, Zhang M, Shi K, Huang Y, She M, Xie R, Zhan S. Age and body mass index are associated with type Ⅲ aortic arch in patients undergoing digital subtraction angiography. Clin Neurol Neurosurg. 2025 Oct;257:109036. doi: 10.1016/j.clineuro.2025.109036. Epub 2025 Jul 1. PMID: 40616974. [IF=1.60 Q4]
• Wang H, He K, Li J, Cao S, Liu H, Dong C, Fan J (Jiaxin Fan), Bai Y, Wei H. Biomechanical properties of double-headed pedicle screws and parallel connectors in thoracolumbar extension revision fixation: a finite element analysis. BMC Musculoskelet Disord. 2026 Feb 2;27(1):187. doi: 10.1186/s12891-026-09545-y. PMID: 41629917; PMCID: PMC12952119. [IF=2.40 Q3]
• Duan M, Zhang N, Ma S, Zhang X, Shi K, Gao T, Yang H, Ma X, Cheng Y, Qu H, Fan J (Jiaxin Fan), Yao Q, Zhan S. Association between Remnant Cholesterol and In-Stent Restenosis in Intracranial and Extracranial Vessels. J Stroke Cerebrovasc Dis. 2025 Dec;34(12):108499. doi: 10.1016/j.jstrokecerebrovasdis.2025.108499. Epub 2025 Nov 20. PMID: 41274587. [IF=1.80 Q4]
• Zhang N, Shi K, Ma S, Zhang X, Duan M, Zhang M, Liu Y, Gao T, Yang H, Ma X, Huang Y, Cheng Y, Qu H, Fan J (Jiaxin Fan), Yao Q, Zhan S. Correlation between lipoprotein(a) and recurrent ischemic events post-cerebral vascular stent implantation. J Stroke Cerebrovasc Dis. 2024 Nov;33(11):107882. doi: 10.1016/j.jstrokecerebrovasdis.2024.107882. Epub 2024 Jul 20. PMID: 39038628. [IF=1.80 Q4]

No content available to display!!!

No content available to display!!!