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ARTICLE TYPE : RESEARCH ARTICLE

Published on :   01 May 2026, Volume - 2
Journal Title :   WebLog Journal of Cancer and Clinical Research | WebLog J Cancer Clin Res | WJCACR
Source URL:   weblog icon https://weblogoa.com/articles/wjcacr.2026.e0101
Permanent Identifier (DOI) :   doi icon https://doi.org/10.5281/zenodo.20002546

An Investigation of the Association Between Periodontal Disease and Cutaneous Melanoma: A Case-Control Study in Greek Adults

Nikolaos Andreas Chrysanthakopoulos 1,2,3 *
Eleftheria Vryzaki 4
Vassiliki Vazintari 5
1Dental Surgeon (DDSc), Oncologist (MSc), Specialized in Clinical Oncology, Cytology and Histopathology, Department of Pathological Anatomy, Medical School, University of Athens, Athens, Greece
2Resident in Maxillofacial and Oral Surgery, 401 General Military Hospital of Athens, Athens, Greece
3Ph.D in Oncology (cand), Registrar in Dentistry, NHS of Greece, Greece
4MD, Ph.D, Department of Dermatology, Rio University Hospital of Patras, Greece
5MD, Registrar in Pathology, Ilioupoli Health Centre - NHS of Greece, Athens, Greece

Abstract

Background/Aim: Previous investigations have showed biological linkages between Periodontal Disease and various types of cancer, such as oral/head and neck cancer, gastric cancer, esophageal cancer, kidney cancer, lung cancer, prostate cancer, hematological malignancies, and cutaneous melanoma. This research investigation aimed to assess the possible association between Periodontal Disease indices and the risk of Cutaneous Melanoma.

Materials and Methods: The current case-control study was consisted of 86 individuals suffered from Cutaneous Melanoma and 172 matching healthy ones, who were recruited from one Dental and two Medical private practices, and completed a standardized health questionnaire, and clinically examined. Periodontal status comprised the following clinical indices Probing Pocket Depth (PPD), Clinical Attachment Loss (CAL), Gingival Index (GI), and Plaque Index (PlI). The models of univariate and logistic regression adjusted for possible confounders were applied for data analysis.

Results: The presence of a CM family history (p=0.000, OR=5.442), deeper Periodontal Pockets (PPD) (p=0.040, OR=1.887), and moderate/severe Gingival Inflammation (GI) (p=0.045, OR=1.542), were statistically significantly associated with the risk of CM developing, compared to healthy individuals, after controlling for smoking, educational and socio-economic status.

Conclusions: The current research suggested positive associations of individuals with CM family history, deeper periodontal pockets, and moderate/severe gingival inflammation, with CM development.

Keywords: Periodontal Disease; Cutaneous Melanoma; Risk Factors; Adults

Citation

Chrysanthakopoulos NA, Vryzaki E, Vazintari V. An Investigation of the Association Between Periodontal Disease and Cutaneous Melanoma: A Case-Control Study in Greek Adults. WebLog J Cancer Clin Res. wjcacr.2026.e0101. https://doi.org/10.5281/zenodo.20002546
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