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ARTICLE TYPE : CASE REPORT

Published on :   01 Jan 2026, Volume - 1
Journal Title :   WebLog Journal of Clinical Case Reports | WebLog J Clin Case Rep
Source URL:   weblog iconhttps://weblogoa.com/articles/wjccr.2026.a0101
Permanent Identifier (DOI) :  doi iconhttps://doi.org/10.5281/zenodo.18204117

Neonatal Hypoganglionosis Presenting as Acute Appendicitis in a 3‑year‑old Girl: A Case Report

Govani DR 1
Mehta AR 2
Midha PK 3
Govani ND 1
Panchasara NG 1
Patel RR 1
Patel RV 1 *
1Department of Pediatrics and Pediatric Surgery, Postgraduate Institute of Child Health & Research and KT Children Govt. University Teaching Hospital, Rajkot 360001, Gujarat, India
2Formerly Head, Department of Surgery at Tata Memorial Hospital, Mumbai, India
3J. Watumull Global Hospital & Research Centre, Delwara Road, Mount Abu, Rajasthan 307501, India Affiliated to Medical Faculty of God Fatherly Spiritual University, Mount Abu, Rajasthan, India

Abstract

Neonatal hypoganglionosis is a rare congenital dysganglionosis typically presenting in the neonatal period with intestinal obstruction. Initial symptoms may include intermittent massive abdominal distension and non-bilious vomiting. Presentation beyond infancy is common, often subtle and easily missed, while acute appendicitis following inadequate conservative therapy is exceptionally rare. We describe a 3-year-old girl who presented with atypical features of acute appendicitis, posing a diagnostic challenge. She underwent laparoscopic appendicectomy, and previously neonatal rectal suction biopsy histopathology revealed features consistent with hypoganglionosis involving the distal rectum. This case highlights the diagnostic complexity of atypical enteric neuropathies and underscores the importance of histological evaluation in neonatal distal partial functional bowel obstruction.

Keywords: Hypoganglionosis; Enteric Neuropathy; Acute Appendicitis; Paediatric Motility Disorder; Fecalith; Histopathology; Appendicectomy; Congenital Dysganglionosis; Hirschsprung Disease Differential; Bowel Regimen; Myenteric Plexus; Delayed Presentation; Neonatal Bowel Dysfunction; Paediatric Gastrointestinal Surgery

Citation

Govani DR, Mehta AR, Midha PK, Govani ND, Panchasara NG, Patel RR, et al. Neonatal Hypoganglionosis Presenting as Acute Appendicitis in a 3-year-old Girl: A Case Report. WebLog J Clin Case Rep. wjccr.2026.a0101. https://doi.org/10.5281/zenodo.18204117
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