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ARTICLE TYPE : RESEARCH ARTICLE

Published on :   28 Jan 2026, Volume - 2
Journal Title :   WebLog Journal of Dermatology | WebLog J Dermatol
Source URL:   weblog iconhttps://weblogoa.com/articles/wjd.2026.a2803
Permanent Identifier (DOI) :  doi iconhttps://doi.org/10.5281/zenodo.18463354

Increased Risk of Adverse Cardiovascular Outcome in Psoriasis: A Retrospective Analysis Using a Large Database

Zinabu S 1
Hubbard D 1
Beyene E 1
Bisrat M 1 *
Beyene M 1
Karodeh N 1
Henry S 1
Young J 1
Ugarte A 1
Sen A 1
Michael M 1
1Howard University College of Medicine, Washington, DC 20059, USA

Abstract

Background: Psoriasis, a chronic inflammatory skin condition, is linked to an increased risk of cardiovascular diseases due to shared inflammatory pathways. However, the direct impact of psoriasis on cardiovascular risk factors remains underexplored. This study investigates the relationship between psoriasis and cardiovascular events, including Myocardial Infarction (MI), stroke, heart failure, arrhythmias, and thromboembolic diseases.

Methods: A nationwide retrospective cohort study was conducted using de-identified Electronic Health Records (EHRs) from 93 healthcare organizations over 20 years. Two cohorts were analyzed: psoriasis patients and non-psoriasis controls, aged 18-60 years. Propensity Score Matching (PSM) balanced baseline characteristics, and the primary outcome was the occurrence of cardiovascular events within 10 years. Survival analyses and Risk Ratios (RR) were used to assess the relationship between psoriasis and cardiovascular outcomes.

Results: After matching, each cohort included 120,527 patients. Psoriasis patients had a significantly higher risk of cardiovascular outcomes, with a 28% increased risk of acute MI (RR: 1.28), 23% higher stroke risk (RR: 1.23), 40% higher heart failure risk (RR: 1.40), 60% higher arrhythmia risk (RR: 1.60), and 46% higher thromboembolism risk (RR: 1.46). Psoriasis patients also had higher risks of ischemic heart disease and transient ischemic attacks. Survival analyses showed lower survival probabilities for psoriasis patients across most outcomes.

Conclusion: Psoriasis is significantly associated with an increased risk of cardiovascular events, underscoring the need for proactive cardiovascular risk management in psoriasis patients.

Keywords: Psoriasis; Cardiovascular Events; Myocardial Infarction (MI); Stroke; Heart Failure; Arrhythmias; Thromboembolic Diseases

Citation

Zinabu S, Hubbard D, Beyene E, Bisrat M, Beyene M, Karodeh N, et al. Increased Risk of Adverse Cardiovascular Outcome in Psoriasis: A Retrospective Analysis Using a Large Database. WebLog J Dermatol. wjd.2026.a2803. https://doi.org/10.5281/zenodo.18463354
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