ARTICLE TYPE : CASE SERIES
Published on : 10 Jan 2026, Volume - 1
Journal Title : WebLog Journal of Endocrinology and Diabetes | WebLog J Endocrinol Diabetes
Source URL: 
https://weblogoa.com/articles/wjed.2026.a1008
Permanent Identifier (DOI) : 
https://doi.org/10.5281/zenodo.18302899
Wolfram Syndrome: A Series of 4 Cases
2Department of Dermatology, Mohammed VI University Hospital, Agadir, Morocco
Abstract
Wolfram Syndrome (WS), also known as DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), is a rare neurodegenerative disorder [1, 2]. This condition features symptoms that typically appear progressively from childhood through adulthood [3, 4, 5]. Diagnosis is based on specific clinical criteria and confirmed by genetic testing for mutations in the WFS1 gene [6, 7]. Insulin therapy remains the mainstay treatment for diabetes mellitus, but incretin analogs may provide benefit if initiated early [8, 9]. Prognosis is generally poor, with a mean life expectancy of 39 years, often due to central respiratory complications [3, 10]. Gene therapyiscurrentlyexperimental but promising [11].
Citation
Gorgi K, Chaouche M, Rifai K, Iraqi H, Gharbi M.H. Wolfram Syndrome: A Series of 4 Cases. WebLog J Endocrinol Diabetes. wjed.2026.a1008. https://doi.org/10.5281/zenodo.18302899