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ARTICLE TYPE : CASE SERIES

Published on :   17 Jan 2026, Volume - 2
Journal Title :   WebLog Journal of Endocrinology and Diabetes | WebLog J Endocrinol Diabetes
Source URL:   weblog iconhttps://weblogoa.com/articles/wjed.2026.a1710
Permanent Identifier (DOI) :  doi iconhttps://doi.org/10.5281/zenodo.18392743

Is Epilepsy a Complication of Type 1 Diabetes? A Series of Four Cases and Review of the Literature

K. Gorgi 1 *
M. Chaouche 2
K. Rifai 1
H. Iraqi 1
M.H. Gharbi 1
1Department of Endocrinology and Metabolic Diseases, Ibn Sina University Hospital, Rabat, Morocco
2Department of Dermatology, Mohammed VI University Hospital, Agadir, Morocco

Abstract

Introduction: The association between type 1 diabetes (T1D) and epilepsy has been reported more frequently than in the general population. However, the exact pathophysiological link remains poorly understood.

Objective: To describe the clinical characteristics of patients presenting with an association of T1D and epilepsy and to discuss the possible pathophysiological mechanisms in light of data from the literature.

Methods: A retrospective descriptive study of four patients followed for type 1 diabetes and epilepsy.

Results: All patients had poorly controlled type 1 diabetes, with frequent hypoglycemia in three cases. Epilepsy was generalized in three cases and focal in one case. Brain imaging and EEG were normal in all patients.

Conclusion: The association between T1D and epilepsy appears to be multifactorial, involving autoimmune, metabolic, and possibly genetic mechanisms.

Keywords: Type 1 Diabetes; Epilepsy; Autoimmunity; Anti-GAD; Hypoglycemia

Citation

K. Gorgi, M. Chaouche, K. Rifai, H. Iraqi, M.H. Gharbi. Is Epilepsy a Complication of Type 1 Diabetes? A Series of Four Cases and Review of the Literature. WebLog J Endocrinol Diabetes. wjed.2026.a1710. https://doi.org/10.5281/zenodo.18392743
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