📢 Publish Your Research for Free - Full APC Waiver, No Hidden Charges. Submit Your Article Today! Submit Now →
JImage

ARTICLE TYPE : CASE REPORT

Published on :   29 Jan 2026, Volume - 2
Journal Title :   WebLog Journal of Endocrinology and Diabetes | WebLog J Endocrinol Diabetes
Source URL:   weblog iconhttps://weblogoa.com/articles/wjed.2026.a2902
Permanent Identifier (DOI) :  doi iconhttps://doi.org/10.5281/zenodo.18464102

Double Diabetes: Clinical Features, Pathophysiological Mechanisms, and Therapeutic Challenges Case Series of Three Patients and Literature Review

Gorgi K 1 *
Chaouche M 2
1Department of Endocrinology and Metabolic Diseases, Ibn Sina University Hospital, Rabat, Morocco
2Department of Dermatology, Mohammed VI University Hospital, Agadir, Morocco

Abstract

Double diabetes refers to the coexistence, in the same patient, of immunological features of type 1 diabetes (T1D) and clinical and metabolic manifestations of type 2 diabetes (T2D), especially insulin resistance. This entity, still insufficiently recognized, poses diagnostic and therapeutic challenges, particularly in adults. We report a series of three cases of double diabetes in adult female patients, illustrating the clinical heterogeneity of this condition, and discuss the pathophysiological mechanisms, therapeutic challenges, and the importance of early screening in light of recent literature data.

Keywords: Double Diabetes; Type 1 Diabetes; Type 2 Diabetes; Insulin Resistance; Autoimmunity; Anti-GAD

Citation

K. Gorgi, M. Chaouche. Double Diabetes: Clinical Features, Pathophysiological Mechanisms, and Therapeutic Challenges Case Series of Three Patients and Literature Review. WebLog J Endocrinol Diabetes. wjed.2026.a2902. https://doi.org/10.5281/zenodo.18464102
Read Full Article