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ARTICLE TYPE : CASE PRESENTATION

Published on :   13 Mar 2026, Volume - 2
Journal Title :   WebLog Journal of Endocrinology and Diabetes | WebLog J Endocrinol Diabetes
Source URL:   weblog iconhttps://weblogoa.com/articles/wjed.2026.c1302
Permanent Identifier (DOI) :  doi iconhttps://doi.org/10.5281/zenodo.19269590

Compressive Dyshormonogenetic Goiter in Adults: Two Case Reports and an Updated Literature Review

K. Gorgi 1 *
M Chaouche 2
1Department of Endocrinology, CHP of Tata, Morocco
2Department of Dermatology, Mohammed VI University Hospital, Agadir, Morocco

Abstract

Introduction: Dyshormonogenetic goiter is a rare cause of congenital hypothyroidism secondary to a defect in thyroid hormonogenesis. Despite early replacement therapy, a compressive multinodular goiter may appear in adulthood.

Observations: We report two patients aged 19 and 28 years, followed since childhood for congenital hypothyroidism, who developed a compressive multinodular goiter treated by total thyroidectomy. Histopathological examination confirmed the diagnosis.

Discussion: Dyshormonogenetic goiter poses a diagnostic problem due to its histological similarities with thyroid carcinomas. The risk of malignant transformation, although rare, justifies prolonged follow-up.

Conclusion: Surgery is indicated in compressive forms. The diagnosis is based on histology.

Keywords: Dyshormonogenesis; Congenital Hypothyroidism; Multinodular Goiter; T hyroidectomy

Citation

Gorgi K, Chaouche M. Compressive Dyshormonogenetic Goiter in Adults: Two Case Reports and an Updated Literature Review. wjed.2026.c1302. https://doi.org/10.5281/zenodo.19269590
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