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ARTICLE TYPE : CASE PRESENTATION

Published on :   27 Mar 2026, Volume - 2
Journal Title :   WebLog Journal of Endocrinology and Diabetes | WebLog J Endocrinol Diabetes
Source URL:   weblog iconhttps://weblogoa.com/articles/wjed.2026.c2702
Permanent Identifier (DOI) :  doi iconhttps://doi.org/10.5281/zenodo.19317524

Non-Syndromic Familial Papillary Thyroid Carcinoma: Early Onset and Multifocal Presentation in a mother and Daughter – A Case Report and Updated Literature Review

K. Gorgi 1 *
M. Chaouche 2
1Department of Endocrinology, CHP of Tata, Morocco
2Department of Dermatology, Mohammed VI University Hospital, Agadir, Morocco

Abstract

Introduction: Familial non-medullary thyroid carcinoma accounts for 3-7% of differentiated thyroid cancers. It is defined by the occurrence of papillary thyroid carcinoma in at least two first degree relatives in the absence of a known hereditary syndrome.

Case Presentation: We report the case of a 56-year-old mother and her 35-year-old daughter, both diagnosed with papillary thyroid carcinoma discovered in EU-TIRADS V classified nodules. Histopathological examination revealed multifocal follicular-variant papillary microcarcinomas in the mother and an infiltrative papillary microcarcinoma in the daughter.

Conclusion: Non-syndromic familial papillary thyroid carcinoma may present with earlier onset and multifocal disease. Careful family history assessment and targeted screening of first-degree relatives may allow diagnosis at an early stage.

Keywords: Familial Papillary Carcinoma; Non-Medullary Thyroid Cancer; Multifocality; Family Screening

Citation

Gorgi K, Chaouche M. Compressive Dyshormonogenetic Goiter in Adults: Two Case Reports and an Updated Literature Review. WebLog J Endocrinol Diabetes. wjed.2026.c2702. https://doi.org/10.5281/zenodo.19317524
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