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ARTICLE TYPE : CASE PRESENTATION

Published on :   03 Jan 2026, Volume - 1
Journal Title :   WebLog Journal of Neurology | WebLog J Neurol
Source URL:   weblog iconhttps://weblogoa.com/articles/wjn.2026.a0305
Permanent Identifier (DOI) :  doi iconhttps://doi.org/10.5281/zenodo.18213203

Amlodipine: Guardian or Provocateur? Exploring Its Role in Parkinsonism

Vansh Gulati 2
Elizabeth Beyene 1
Leon Seymour 2
Samrawit Zinabu 1
Ayushi Sen 2
Martin Borissov 3
Syed Fahad Gillan 1
Girma Ayale 1
Mekdem Bisrat 1 *
Miriam Michael 1,3
1Department of Internal Medicine, Howard University, Washington DC, USA
2American University of Antigua, School of Medicine, Antigua W.I.
3Department of Internal Medicine, University of Maryland School of Medicine, Baltimore, MD, USA

Abstract

Drug-induced parkinsonism (DIP) is a debilitating side effect associated with several classes of medications. Amlodipine is a widely used dihydropyridine calcium channel blocker (CCB) commonly prescribed for hypertension and angina. We present a case of a 62-year-old man who underwent liver transplantation and developed parkinsonism shortly after initiation of amlodipine for hypertension. After ruling out other causes for his neurological presentation, discontinuation of amlodipine resulted in a rapid improvement of symptoms, confirming the diagnosis of DIP. This report highlights the importance of recognizing amlodipine as a potential cause of new onset parkinsonism and underscores the need for further research to understand its effects on the dopaminergic pathway.

Keywords: Amlodipine; Parkinson’s Disease; Drug-Induced Parkinsonism; Calcium Channel Blockers; Antihypertensives

Citation

Gulati V, Beyene E, Seymour L, Zinabu S, Sen A, Borissov M, et al. Amlodipine: Guardian or Provocateur? Exploring Its Role in Parkinsonism. WebLog J Neurol. wjn.2026.a0305. https://doi.org/10.5281/zenodo.18213203
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