ARTICLE TYPE : CASE REPORT
Published on : 05 Mar 2026, Volume - 2
Journal Title :
WebLog Journal of Obstetrics and Gynecology | WebLog J Obstet Gynecol
Source URL: 
https://weblogoa.com/articles/wjog.2026.c0505
Permanent Identifier (DOI) : 
https://doi.org/10.5281/zenodo.19079618
Dual Cause of Recurrent Pregnancy Loss: Hashimoto's Thyroiditis and Inherited Protein S Deficiency
2Sfax Faculty of Medicine, University of Sfax, Sfax 3029, Tunisia
3Department of Obstetrics and Gynecology, University Hospital of Gabes, Mtorrech 6014, Tunisia
Abstract
Recurrent pregnancy loss (RPL) is a rare occurrence in routine medical practice complicating 1-3% of all pregnancies. They represent a real diagnostic challenge due to the multitude of possible etiologies, and remain unexplained in more than 50% of cases. We report the original observation of a 32-year-old Tunisian woman investigated for six recurrent early miscarriages. The investigations concluded with a dual etiology: Hashimoto's thyroiditis (free thyroxine at 6 pmol/, thyroid stimulating hormone at 12.4 µIU/mL, positive anti-thyroglobulin antibodies at 32.8 IU/ml, and positive anti-thyroperoxidase (anti-TPO) antibodies at 677 IU/ml) with inherited thrombophilia (protein S deficiency of 41%).
This association, however rare and unusual, deserves to be recognized by clinicians to avoid diagnostic delays and ensure proper management of recurrent miscarriages.
Keywords: Recurrent Pregnancy Loss; Hashimoto's Thyroiditis; Protein S Deficiency; Inherited T hrombophilia; Recurrent Miscarriages; Anti-Thyroperoxidase (Anti-TPO) Antibodies
Citation
Bouomrani S, Letaïef W, Masmoudi I, Ben Teber S, Mahdhaoui W. Dual Cause of Recurrent Pregnancy Loss: Hashimoto's Thyroiditis and Inherited Protein S Deficiency. WebLog J Obstet Gynecol. wjog.2026.c0505. https://doi.org/10.5281/zenodo.19079618