ARTICLE TYPE : REVIEW ARTICLE
Published on : 06 Jun 2026,
Volume - 2
Journal Title :
WebLog Journal of Pediatrics
| WebLog J Pediatr
| WJP
Journal ISSN: 3071-4311
Source URL:
https://weblogoa.com/articles/wjp.2026.f0605
Permanent Identifier (DOI) :
Spontaneous Resolution of Inguinal Hernias and the Role of Gut-related Secretomotor Disorders via the PNEI Axis in Early vs Late Inguinal Hernia Repair in Preterm Infants
2Pediatric Emergency Department, Shree Swaminarayan Vishwa Mangal Gurukul PSM Hospital, Ahmedabad, India
3Department of Pediatric Surgery, Evelina Children’s Hospital, London, UK
4Department of Pediatric Surgery, Nottingham University Hospitals, Nottingham, UK
5Lincoln Uni College, 2, Jalan Stadium, 47301 Petaling Jaya, Selangor, Malaysia
6J. Watumull Global Hospital & Research Centre, Delwara Road, Mount Abu, Rajasthan, India
7Department of Pediatric Surgery, PGICHR and KTCGUH, Rajkot, Gujarat, India
Abstract
Inguinal hernia remains one of the most frequent surgical conditions in preterm infants. While early repair has traditionally been advocated to prevent incarceration, emerging evidence suggests that delayed intervention may allow for spontaneous resolution in select cases. This review synthesizes updated systematic reviews and meta-analyses, incorporating Trial Sequential Analysis (TSA), to evaluate the balance between early versus late repair. Particular attention is given to the role of gut related secretomotor disorders mediated through the Psycho-Neuro-Endocrine-Immune (PNEI) axis, which may underpin spontaneous regression of hernias in preterm infants.
Citation
More AB, Khatri LK, Zaparackaite I, Singh SJ, Swamy KB, Mehta AR, et al. Spontaneous Resolution of Inguinal Hernias and the Role of Gut-related Secretomotor Disorders via the PNEI Axis in Early vs Late Inguinal Hernia Repair in Preterm Infants. WebLog J Pediatr. wjp.2026.f0605. https://doi.org/10.5281/zenodo.20907240