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ARTICLE TYPE : CASE REPORT

Published on :   22 Dec 2025, Volume - 1
Journal Title :   WebLog Journal of Pharmacology and Therapeutics | WebLog J Pharmacol Ther
Source URL:   weblog iconhttps://weblogoa.com/articles/wjpt.2025.l2201
Permanent Identifier (DOI) :  doi iconhttps://doi.org/10.5281/zenodo.18058157

Sertraline-Induced Lipase-Sparing Acute Interstitial Edematous Pancreatitis: A Case Report

Zaparackaite I 1
Singh H 2
Singh SJ 3
Swamy KB 4
Midha PK 5
Patel RV 2,5 *
1Department of Pediatric Surgery, Emergency’s Children’s Surgical Hospital, Entebbe/ Evelina Children’s Hospital, London
2Department of Pediatric Surgery, PGICHR and KTCGUH, Rajkot 360001, Gujarat, India
3Department of Pediatric Surgery, Nottingham University Hospitals, Nottingham, UK
4Lincoln University College, Lincoln University, Kuala Lumpur, Malaysia
5J. Watumull Global Hospital & Research Centre, Delwara Road, Mount Abu, Rajasthan 307501, India Affiliated to Medical Faculty of God Fatherly Spiritual University, Mount Abu, Rajasthan, India

Abstract

Sertraline, a selective serotonin reuptake inhibitor (SSRI), has been associated with rare cases of acute pancreatitis. We report a case of sertraline-induced, lipase-sparing acute interstitial edematous pancreatitis in a young professional, initially misdiagnosed as acute cholecystitis. On rechallenge, the patient developed recurrent symptoms with elevated inflammatory markers but normal ultrasound findings. Contrast-enhanced computed tomography confirmed acute interstitial edematous pancreatitis with associated venous thrombosis. Withdrawal of sertraline and substitution with an alternative antidepressant led to complete resolution. This case highlights the diagnostic challenge of lipase-sparing pancreatitis and underscores the importance of considering drug-induced etiologies.

Keywords: Acute Pancreatitis; Antidepressant; Cholecystitis; Drug-Induced; Lipase; Sertraline; Ssris; Adverse Effects

Citation

Zaparackaite I, Singh H, Singh SJ, Swamy KB, Midha PK, Patel RV. Sertraline-Induced Lipase Sparing Acute Interstitial Edematous Pancreatitis: A Case Report. WebLog J Pharmacol Ther. wjpt.2025.l2201. https://doi.org/10.5281/zenodo.18058157
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