Dr. Shao-Wen Hung, DVM, Ph.D.

E-mail Address: 1032169@mail.atri.org.tw

Education Background:

2002.9-2007.6 - Ph.D. of Veterinary Medicine - Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung 402, Taiwan.
Working Experiences:
Present - Researcher/Chief - Division of Animal Industry, Animal Technology Research Center, Agricultural Technology Research Institute.
Skills:
Establishment of the diseased models; Cell culture; Histopathology; Western blot and PCR; Flow cytometry; Bacteriology; Research of anti-cancer drugs (protein drugs: recombinant viral capsid proteins and fibrillar proteins).

• Fish & Shellfish Immunology
• Oncology & Cancer Medicine
• Veterinary Medicine & Immunology
• Fish Diseases & Therapy
• Flow Cytometry
• Experimental Animal
• Animal Welfare
• Epilepsy

• Hung SW, Chen YP, *Chu RM. 2001. Surface antigen expressions of canine peripheral blood lymphocytes in different breeds, sex, and seasons. Taiwan Veterinary Journal 27: 137-142. (in Chinese)
• *Chu RM, Lin CY, Liu CC, Yang SY, Hsiao YW, Hung SW, Pao HN, Liao KW. 2001. Proliferation characteristics of canine transmissible venereal tumor. Anticancer Research 21: 4017-4024.
• Hsiao YW, Liao KW, Hung SW, *Chu RM. 2002. Effect of tumor infiltrating lymphocytes on the expression of MHC molecules in canine transmissible venereal tumor cells. Veterinary Immunology and Immunopathology 87: 19-27.
• 1Liao KW, 1Hung SW, Hsiao YW, Bennett M, *Chu RM. 2003. Canine transmissible venereal tumor cell depletion of B lymphocytes: molecule(s) specifically toxic for B cells. Veterinary Immunology and Immunopathology 92: 149-162. 1Contributed equally to this work
• Hsiao YW, Liao KW, Hung SW, *Chu RM. 2004. Tumor-infiltrating lymphocyte secretion of IL-6 antagonizes tumor-derived TGF-beta 1 and restores the lymphokine-activated killing activity. Journal of Immunology 172: 1508-1514.
• Huang YC, Hung SW, Jan TJ, Liao KW, Wang YS, Cheng CH, *Chu RM. 2008. CD5-low expression lymphocytes in canine peripheral blood show characteristics of natural killer cells. Journal of Leukocyte Biology 84: 1501-1510.
• Lin CC, Hung SW, Tu CY, Tsou LT, Shieh MT, Lin SL, Liu PC, *Wang WS. 2008. Spontaneous stomach lymphoma and liver metastases in flower horn fish (hybrid cichlid). Bulletin of the European Association of Fish Pathologists 28: 115-120.
• Chen TA, Wang JL, Hung SW, Chu CL, Cheng YC, *Liang SM. 2011. Recombinant VP1, an Akt inhibitor, suppresses progression of hepatocellular carcinoma by inducing apoptosis and modulation of CCL2 production. PLoS One 6: e23317.
• Peng JM, Chen YH, Hung SW, Chiu CF, Ho MY, Lee YJ, Lai TC, Hsiao M, *Liang CM, *Liang SM. 2012. Recombinant viral protein promotes apoptosis and suppresses invasion of ovarian adenocarcinoma cells by targeting α5β1 integrin to downregulate Akt and MMP-2. British Journal of Pharmacology 165: 479-493.
• Chiu CF, Peng JM, Hung SW, *Liang CM, *Liang SM. 2012. Recombinant viral capsid protein VP1 suppresses migration and invasion of human cervical cancer by modulating phosphorylated prohibitin in lipid rafts. Cancer Letters 320: 205-214.
• Hung SW, Chiu CF, Chen TA, Chu CL, Huang CC, Shyur LF, *Liang CM, *Liang SM. 2012. Recombinant Viral Protein VP1 Suppresses HER-2 Expression and Migration/Metastasis of Breast Cancer. Breast Cancer Research and Treatment 136: 89-105.
• Chiu CF, Ho MY, Peng JM, Hung SW, Lee WH, *Liang CM, *Liang SM. 2013. Raf activation by Ras and promotion of cellular metastasis require phosphorylation of prohibitin in the raft domain of plasma membrane. Oncogene 32: 777-787.
• Ho MY, *Liang SM, Hung SW, *Liang CM. 2013. MIG-7 controls COX-2/PGE2-mediated lung cancer metastasis. Cancer Research 73: 439-449.
• Ho MY, Hung SW, *Liang SM, *Liang CM. 2014. Recombinant viral capsid protein VP1 suppresses lung cancer metastasis by inhibiting COX-2/PGE2 and MIG-7. Oncotarget 5: 3931-3943.
• *Hung SW, Chen CC, Chiu CC, Lin JW, Yang CY. 2018. Establishment of anti-lung adenocarcinoma drug screening platform in mice. Ilan University Journal of Bioresources 14: 41-66. (in Chinese).
• Hung SW, Lin CJ, Lin YS, Tu CY, Shih CW, *Wang WS. 2003. Case report: Pseudodactylogyridiasis and anguillicolosis in swamp eels. Taiwan Veterinary Journal 29: 276-281. (in Chinese)
• Tu CY, Lin YH, Wei YL, Shih CW, Hung SW, *Wang WS. 2003. In vitro and in vivo replication of aquatic birnavirus in tilapia (Oreochromis aureus) tissues. Taiwan Veterinary Journal 29: 323-332. (in Chinese)
• *Wang WS, Hung SW, Ooi HK, Lin YH, Shih CW, Tu CY, Hsing HL. 2004. Case report: A parasitosis case of gunther, Acrossocheilus paradoxus (Cyprinidae) infected with Clinostomum sp. (Trematoda: Clinostomidae). Taiwan Veterinary Journal 30: 263-270. (in English)
• *Wang WS, Hung SW, Lin YH, Shih CW, Tu CY, Tung KC, Chen PR, Ooi HK. 2006. Parasitosis of short-finned eel, Anguilla australis schmidti, in Taiwan. Bulletin of the European Association of Fish Pathologists 26: 106-111.
• Hung SW, Tu CY, Tsou LT, Chang CH, Lin CC, *Wang WS. 2006. A case of swollen abdomen disease in giant grouper, Epinephelus lanceolatus, remedied by vitamin C and E supplementation. Bulletin of the European Association of Fish Pathologists 26: 267-270.
• Hung SW, Tu CY, *Wang WS. 2007. In vivo effects of adding singular or combined anti-oxidative vitamins and/or minerals to diets on the immune system of tilapia (Oreochromis hybrids) peripheral blood monocyte-derived, anterior kidney-derived, and spleen-derived macrophages. Veterinary Immunology and Immunopathology 115: 87-99.
• Hung SW, Kong PH, Shih CW, Tu CY, Ho SP, *Wang WS. 2007. The antibiotic susceptibility and expression of amoxicillin-resistant genes in Vibrio strains isolated from hard clams, Meretrix meretrix in Taiwan. Taiwan Veterinary Journal 33: 20-29. (in English)
• *Wang WS, Hung SW, Lin YH, Tu CY, Wong ML, Chiou SH, Shieh MT. 2007. The effects of five different glycans on innate immune responses by phagocytes of hybrid tilapia and Japanese eels Anguilla japonica. Journal of Aquatic Animal Health 19: 49-59.
• Hung SW, Tu CY, *Wang WS. 2007. In vitro effects of singular or combined anti-oxidative vitamins and/or minerals on tilapia (Oreochromis hybrids) peripheral blood monocyte-derived, anterior kidney-derived, and spleen-derived macrophages. Fish & Shellfish Immunology 23: 1-15.
• Tu CY, Hung SW, Tsou LT, Chang YC, *Wang WS. 2007. Simultaneous flow cytometric assessment for cellular types and phagocytic abilities of the haemocytes of the hard clam, Meretrix Lusoria. Fish & Shellfish Immunology 23: 16-23.
• Hung SW, Lin YH, Tu CY, Wong ML, Chiou SH, *Wang WS. 2007. Effects of cytokines and lipopolysaccharide on the functions of tilapia head kidney-derived macrophages. Taiwan Veterinary Journal 33: 96-103. (in Chinese)
• *Wang WS, Hung SW, Lin YH, Tu CY, Wong ML, Chiou SH, Shieh MT. 2007. Purification and localization of nitric oxide synthases from hybrid tilapia (Nile Tilapia × Mozambique Tilapia). Journal of Aquatic Animal Health 19: 168-178.
• Hung SW, Wang SL, Tu CY, Tsai YC, Chuang ST, Shieh MT, *Wang WS. 2007. The antimicrobial susceptibility of Streptococci obtained from cattle and fish in Taiwan from 2003-2004. BioFormosa 42: 63-72. (in Chinese)
• Hung SW, Wang SL, Tu CY, Tsai YC, Chuang ST, Shieh MT, Liu PC, *Wang WS. 2008. Antibiotic susceptibility and prevalence of erythromycin ribosomal methylase gene, erm(B) in Streptococcus spp. Veterinary Journal 176: 197-204.
• Liu PC, Lin CC, Lin SL, Chen MH, Lee OH, Chen YK, Tung KC, Chen YP, Tu CY, Hung SW, *Wang WS. 2011. Vesicular diseases associated with poxvirus-like infection in cultured soft shell turtles (Pelodiscus sinensis) in Taiwan. Bulletin of the European Association of Fish Pathologists 31: 73-80.
• Cheng CF, Hung SW, Lin YH, Liu PC, Chen MH, Tu CY, Chang CH, Chiou SH, *Wang WS. 2011. Effects of adding nitric oxide donors and immuno-stimulators on anterior kidney-derived macrophages of tilapia (Oreochromis hybrids) toward apoptosis. Taiwan Veterinary Journal 37: 169-179. (in Chinese)
• Chen MH, Hung SW, Lin YH, Cheng CF, Tu CY, Chang CH, Wong ML, *Wang WS. 2011. Non-specific immune responses of hybrid tilapia (Oreochromis Niloticus × Oreochromis Mossambicus) anterior kidney-derived macrophage against different aquatic bacteria. Taiwan Veterinary Journal 37: 203-213. (in Chinese)
• Liu PC, Hung SW, Chen MH, Cheng CF, Lin CC, Chang CH, Lin SL, Tu CY, Lin YH, *Wang WS. 2011. Highly virulent Photobacterium damselae subsp. piscicida isolated from Taiwan paradise fish, Macropodus opercularis (L.), in Taiwan. African Journal of Microbiology Research 5: 2107-2113.
• Hung SW, Liu PC, Lin SL, Tung KC, Chang CH, Chan CY, *Wang WS. 2011. Case report: A case of Haplorchis pumilio infection in golden severum, Heros severus var., in Taiwan. Taiwan Veterinary Journal 37: 246-252. (in English)
• Hung SW, Chang YC, Chen MH, Cheng CF, Tu CY, Lin YH, Lin SL, Liu PC, Chang CH, Tsou LT, *Wang WS. 2011. Classification and Morphology Observation of Hemocytes in Bivalves. BioFormosa 46: 13-20. (in Chinese)
• Liu PC, Wang CY, Lin SL, Lin CC, Hung SW, Chang CH, Tu CY, Chen MH, Yi-Peng Chen YP, *Wang WS. 2012. Establishment of a soft shell turtle, Pelodiscus sinensis, embryo primary cell culture for studies of soft shell turtle poxvirus-like virus replication and characteristics. African Journal of Microbiology Research 6: 960-967.
• Chen MH, Hung SW, Shyu CL, Lin CC, Liu PC, Chang CH, Shia WY, Cheng CF, Lin SL, Tu CY, Lin YH, *Wang WS. 2012. Lactococcus lactis subsp. lactis infection in Bester sturgeon, a cultured hybrid of Huso huso × Acipenser ruthenus, in Taiwan. Research in Veterinary Science 93: 581-588.
• Cheng CF, Hung SW, Chang YC, Chen MH, Chang CH, Tsou LT, Tu CY, Lin YH, Liu PC, Lin SL, *Wang WS. 2012. Purification and characterization of hemagglutinating proteins from Poker-chip Venus (Meretrix lusoria) and Corbicula clam (Corbicula fluminea). Scientific World Journal 2012: 906737.
• Cheng CF, Hung SW, Tsou LT, Hsu TH, Chen MH, Chang CH, Tu CY, Lin YH, Lin SL, *Wang WS. 2012. A simple and rapid method for analysis of the immunological effects of beta-glycans in serum and intra-haemocytic components of mangrove crab (Scylla serrata). African Journal of Microbiology Research 6: 6340-6347.
• Chen MH, Hung SW, Chang CH, Wang JL, Lin CC, Lin SL, Cheng CF, Tu CY, Lin YH, Hsu TH, *Wang WS. 2012. Long term malnutrition and multiple chronic granuloma in discus fish (Symohysodon sp.). BioFormosa 47: 15-20. (in Chinese)
• Hung SW, Lin YH, Hsu TH, Hsing SL, Chang CH, Cheng CF, Chen MH, Tu CY, Lin SL, *Wang WS. 2012. The complicated infection of Photobacterium damselae subsp. piscicida and Edwardsiella ictaluri in paradise fish (Maclopodus opercukaris Linnaeus). BioFormosa 47: 35-41. (in Chinese)
• Chen MH, Hung SW, Chang CH, Chen PY, Lin CC, Liu PC, Cheng CF, Lin SL, Tu CY, Tsang CL, Lin YH, *Wang WS. 2013. Red sea bream iridovirus infection in marble goby (Bleeker, Oxyeleotris marmoratus) in Taiwan. African Journal of Microbiology Research 7: 1009-1014.
• Hung SW, Hsieh YC, Chang CH, Tu CY, Lin YH, Cheng CF, Chen MH, Hsu TH, Lin SL, *Wang WS. 2014. Development and application of monoclonal antibodies to peripheral blood monocyte derived macrophages of hybrid tilapia (Oreochromis niloticus × Oreochromis mossambicus). BioFormosa 49: 1-12. (in Chinese)
• Chiu CT, Kuo SN, Hung SW, *Yang CY. 2017. Combined treatment with hyaluronic acid and mesalamine protects rats from inflammatory bowel disease induced by intracolonic administration of trinitrobenzene sulfonic acid. Molecules 22: 904.
• Chang YC, Ching YH, Chiu CC, Liu JY, Hung SW, Huang WC, Huang YT, *Chuang HL. 2017. TLR2 and interleukin-10 are involved in Bacteroides fragilis-mediated prevention of DSS-induced colitis in gnotobiotic mice. PLoS ONE 12(7): e0180025.
• *Hung SW, Lin JW, Chen CC, Hung RC, Lin HW, Lin CY, Chiu CC, *Yang CY. 2017. Evaluation of the relevance degree on histopathological changes and eosinophils expression under establishment of a mouse model with asthma via ovalbumin induction. Journal of the Chinese Society of Animal Science 46: 121-136. (in Chinese)
• Chen YH, Chiu CC, Hung SW, Liu JY, Wang YC, Qiang LV, Hsu CC, Huang YW, Huang WC, *Chuang HL, *Chen TH. 2017. Effects of plant- and animal-based high-fat diets on lipid storage and distribution in environmental bacteria-colonized gnotobiotic mice. Biochemical and Biophysical Research Communications 493: 1075-1081.
• Hung SW, Tsai YC, Ho SP, Tu CY, Wang SL, *Wang WS. 2005. A study for amoxicillin residue detection technique. Taiwan Veterinary Journal 31: 46-55. (in Chinese)
• *Wang WS, Shih CW, Hung SW, Ling YF, Tu CY, Chen BR, Tsou LT, Ho SP. 2006. Development and application of the enzyme-linked immunosorbent assay residual detection kits for fluoroquinolones. Taiwan Veterinary Journal 32: 391-403. (in Chinese)
• Tu CY, Ho SP, Hung SW, Chen BR, Tsou LT, *Wang WS. 2006. Development of a technique to detect the residue of oxolinic acid in the serum and muscle of Chinese mitten crab, Eriocheir Sinensis. Journal of Food and Drug Analysis 14: 391-397.
• Ling YF, Hung SW, Chen BR, Tsou LT, Tu CY, Chang CH, Ho SP, *Wang WS. 2007. Development of the enzyme-linked immunosorbent assay residual detection kit for ciprofloxacin. BioFormosa 42: 73-80. (in Chinese)
• Tu CY, Ho SP, Hung SW, Chen BR, Tsou LT, Lin YF, Chung CS, *Wang WS. 2007. Determination of oxolinic acid residue in the hepatopancreas and gonad of Chinese mitten crab, Eriocheir Sinensis. Taiwan Veterinary Journal 33: 56-65. (in Chinese)
• Hung SW, Shih CW, Chen BR, Ling YF, Tsou LT, Tu CY, Ho SP, *Wang WS. 2007. A new detection technique for fluoroquinolone-conjugated proteins by high performance liquid chromatography with UV/fluorescence detectors. Journal of Food and Drug Analysis 15: 71-74.
• Wang WS, Chen BR, Lin YH, Chang CH, Hsieh YC, Tu CY, Hsu TH, *Hung SW. 2015. Using ciprofloxacin monoclonal antibody to develop the enzyme-linked immunosorbent assay detection kit. Journal of the Chinese Society of Animal Science 44: 304-319. (in Chinese)
• Wang WS, Chen BR, Lin YH, Chang CH, Hsieh YC, Tu CY, Hsu TH, *Hung SW. 2016. Development of the enzyme-linked immunosorbent assay kits for oxolinic acid. Journal of the Chinese Society of Animal Science 45: 27-44. (in Chinese)
• Lin YH, Wang WS, Ling YF, Chang CH, Tu CY, Hsu TH, *Hung SW. 2016. Development of enzyme-linked immunosorbent assay residual detection kits for β-lactam antibiotics. Journal of the Chinese Society of Animal Science 45: 197-222. (in Chinese)
• Hung YW, Lin YH, Lin YF, Wang WS, Chiu CF, Chiu CC, Chiu HW, *Hung SW. 2018. Estimation of beta-lactam antibiotics-serum albumin conjugated proteins by high performance liquid chromatography with ultraviolet detector. Journal of Antibiotics Research 2(1): 103.
• Hung YW, Lin YH, Chen MH, Wang WS, Chiu CF, Chiu CC, Chiu HW, Tsai WH, *Hung SW. 2018. Pharmacokinetic study of florfenicol in Bester sturgeon, a cultured hybrid of Huso huso × Acipenser ruthenus by high performance liquid chromatography equipped with UV detector. Aquaculture 495: 558-567.
• 1Hung YW, 1Hung SW, Wu YC, Wong LK, Lai MT, Shih YH, *Lee TS, *Lin YY. 2015. Soluble epoxide hydrolase activity regulates inflammatory responses and seizure generation in two mouse models of temporal lobe epilepsy. Brain Behavior and Immunity 43: 118-129. 1Contributed equally to this work.
• 1Chiu CC, 1Wang YC, Huang WC, Chen YH, Hung SW, Huang YT, Chuang HL, *ChangYC. 2017. Differences in genetic background contribute to Pseudomonas exotoxin A-induced hepatotoxicity in rats. Toxins 9: 224. (1: Equal contribution to the work).
• Lin JW, Chen CC, Chiu CC, Yang CY, *Hung SW. 2017. A study to establish a mouse genotoxicity model by mitomycin C induction. Journal of the Chinese Society of Animal Science 46: 193-207. (in Chinese).

No content available to display!!!

No content available to display!!!