Dr. Mariam Lotfy Khaled is a postdoctoral research fellow at Moffitt Cancer Center and an assistant professor of Biochemistry at Cairo University. She holds a Ph.D. in Cellular Biology and Anatomy from Augusta University and a B.Pharm from Cairo University, graduating with honors.

Dr. Khaled’s research focuses on the metabolic and immune mechanisms driving therapy resistance and neurodegeneration in leptomeningeal disease (LMD), with a particular emphasis on branched-chain ketoacids. Her work integrates spatial transcriptomics, single-cell sequencing, and advanced imaging.

She has received multiple awards, including the Junior Scientist Research Partnership Award and AACR Scholar-in-Trainee Awards, and has authored over 15 publications in leading journals such as Cell Reports Medicine and Cancer Research. Dr. Khaled is also an active mentor, educator, and scientific reviewer, with a strong commitment to translational research that improves patient outcomes in CNS metastases.

• Cancer Metabolism
• Neuro-Oncology
• Tumor Microenvironment & Immunology
• Spatial and Single-Cell Transcriptomics
• Translational Oncology
• Exosome Biology & Liquid Biopsy
• Genomics and Molecular Genetics

• Alhaddad, H. et al. Spatial transcriptomics analysis identifies a tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease. Cell Reports Medicine (2024).
• Hadvina, R. et al. Exosomes and their miRNA/protein profile in keratoconus-derived corneal stromal cells. Experimental eye research 236, 109642 (2023).
• Khaled, M. L. et al. Branched-chain keto acids exert an immune-suppressive and neurodegenerative microenvironment in CNS leptomeningeal lymphoma. Cancer Research 83, 1192-1192 (2023).
• Khaled, M. L. et al. Branched-chain keto acids promote an immune-suppressive and neurodegenerative microenvironment in leptomeningeal disease. bioRxiv (2023).
• Mariam Lotfy Khaled, A. A. T., Peter A. Forsyth, Inna Smalley & Piña, Y. Leptomeningeal Disease (LMD) in Patients with Melanoma Metastases. Cancers 15, 1884 (2023).
• Khaled, M. L. et al. PPIP5K2 and PCSK1 are candidate genetic contributors to familial keratoconus. Scientific Reports 9, 19406 (2019).
• Rabab Sharif, M. L. K., Tina B. McKay, Yutao Liu, & Karamichos, D. Transcriptional profiling of corneal stromal cells derived from patients with keratoconus. Scientific report 9, 12567 (2019).
• Khaled, M. L. & Liu, Y. in Genetics and Genomics of Eye Disease. 219-235 (Academic Press, 2020).
• Liu, Y. et al. PPIP5K2 mutations & Keratoconus in Human Patients and Mouse Models. Invest Ophthalmol Vis Sci 60, 4784-4784 (2019).
• Sharif, R., Khaled, M., She, J.-X., Liu, Y. & Karamichos, D. Exosomes and their miRNA/protein contents in Keratoconus. Invest Ophthalmol Vis Sci 60, 314-314 (2019).
• Khaled, M. L. et al. Homozygous mutation in the ELMO3 gene with keratoconus. Invest Ophthalmol Vis Sci 59, 743-743 (2018).
• Liu, Y. et al. Long Non-Coding RNAs in Keratoconus-affected Human Cornea. Invest Ophthalmol Vis Sci 59, 4391-4391 (2018).
• Khaled, M. L. et al. Differential expression of coding and long noncoding RNAs in keratoconusaffected corneas. Invest Ophthalmol Vis Sci 59, 2717-2728 (2018).
• Khaled, M. L. et al. Molecular and histopathological changes associated with keratoconus. BioMed research international 2017, 7803029 (2017).
• Helwa, I. et al. A comparative study of serum exosome isolation using differential ultracentrifugation and three commercial reagents. PloS one 12, e0170628 (2017).
• Bykhovskaya, Y. et al. TSC1 mutations in keratoconus patients with or without tuberous sclerosis. Invest Ophthalmol Vis Sci 58, 6462-6469 (2017).
• Mariam Lotfy Khaled, Ethan Vallebuona, Yuan Ren, Ronak Kundalia1, Hasan Alhaddad, Zhihua Chen, Gerald C. Wallace, Brittany Evernden, Oscar E. Ospina, MacLean Hall, Min Liu, Lancia. Darville, Victoria Izumi, Ann Chen, Shari Pilon-Thomas, Paul A. Stewart, John M. Koomen, Salvatore A. Corallo, Michael D. Jain, Sheri Holmen, Ana P. Gomes, Timothy J. Robinson, Fredrick L. Locke, Peter A. Forsyth, Inna Smalley, A pan-cancer atlas of leptomeningeal disease reveals metabolic determinants of immunosuppression and neurodegeneration, Submitted.
• Ronak Kundalia, Ethan Vallebuona, Mariam Khaled, Oscar Ospina, Karl Nyman, Gerald Wallace, Peter Forsyth, Pina Yolanda, Inna Smalley. A retrospective analysis of the incidence, clinical characteristics and outcomes of leptomeningeal disease in patients with metastatic melanoma, Ready for Submission.
• Yuan Ren, Mariam Khaled, Ethan Vallebuona, Inna Smalley. Macrophages provide a protective microenvironment for tumor progression in Leptomeningeal Disease, in Prep.
• M.Baraa Bozoo, Mariam Khaled, Oscar Ospina, Ethan Vallebuona, Inna Smalley. A retrospective analysis of the incidence, clinical characteristics and outcomes of leptomeningeal disease in patients with Lung Cancer, in Prep.

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• https://orcid.org/0009-0009-2088-3801
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