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Review Article | Open Access

Published on: 05 Mar 2026

Article ID: wjggr.2026.c0507

Pathogenicity, Species, and Resistance: Fixed Categories or Functional Constructs? A Call for Relational Microbiology
Max Roberto Batista Araújo* 1 Vasco Azevedo 2

Classical microbiology has long relied on discrete categories to define bacterial species, pathogenicity, and antimicrobial resistance. However, comparative genomics of neglected species reveals the limitations of these rigid frameworks. Using Corynebacterium glucuronolyticum as a paradigm, we argue that these concepts are better understood as functional constructs that depend on genomic, ecological, and clinical contexts rather than fixed biological entities. This perspective challenges…

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