Our DFT calculation provided the first theoretical investigation on Pd(OAc)2-catalyzed spiro cyclisation of sulfonamide with maleimide. Initially, Pd(OAc)2 is coordinated with quinoline leading to first N-Pd bond. Subsequently, via coordination of sulfonamide to Pd, the second N-Pd bond is generated after liberation of first acetic acid AcOH. Then C-Pd bond is formed by activation of γ-C(sp3)−H bond during formation of key five-membered ring intermediate together with leaving of second AcOH.…

This study aims to compare the applications and impacts of quantitative and qualitative research in the social sciences. Quantitative research, through the collection and statistical analysis of numerical data, can provide objective and reproducible results, making it suitable for large sample studies and hypothesis testing. Its strengths lie in the ability to conduct broad comparisons and inferences through quantitative indicators, while its limitations may include overlooking complex…

Introduction: Arginine may be associated with the latent herpesvirus reactivation and L-lysine has been shown to inhibit certain viral replication phases by antagonizing arginine.

Case Presentation: Man with latent HHV-1 experienced work-related stress but only after an arginine overloud, an initial recurrent labial herpes was observed. A loading dose of L-lysine was prescribed that day, followed by a maintenance dose for 30 days. Arginine-rich…

This study investigates the mechanism by which college students' Future Time Perspective influences their Learning Engagement. We conducted a survey with 550 Chinese undergraduates using three reliable and valid scales measuring Future Time Perspective, Learning Engagement, and Self-Efficacy. The results revealed that: (1) Future Time Perspective significantly and positively predicts Learning Engagement; (2) Self-Efficacy positively predicts Learning Engagement; and (3) Future Time…

Borderline Personality Disorder is a severe psychological disorder characterized by emotional instability, chaotic interpersonal relationships, and a disturbed self-image. This study adopts a qualitative research approach, using literature analysis to explore the underlying causes of Borderline Personality Disorder, the interpersonal difficulties faced by individuals with Borderline Personality Disorder, current treatment methods, and existing challenges in treatment. The findings…

With the acceleration of socialization, people's work pressure is getting bigger and bigger, which has become an important influencing factor for the decline of sleep quality, and more and more people are suffering from the decline of sleep quality. In the clinic, many people begin to receive long-term medication, in spite of this, the problem of sleep quality has not been well improved. This study will systematically analyze the relationship between sleep quality and health, the…

This study reviews the academic literature on the causes and impacts of Narcissistic Personality Disorder (NPD), as well as the resistance and challenges encountered in clinical treatment, providing new therapeutic approaches for future clinical interventions. Individuals with NPD tend to exaggerate their self-importance, maintain a persistent focus on their self-image, lack empathy, and show insensitivity to the needs of others. NPD has profound negative effects on both individuals and…

Thyroid disorders, including hypothyroidism and hyperthyroidism, are among the most prevalent endocrine conditions in India, often leading to persistent psychological symptoms such as perceived stress. While pharmacological treatments address hormonal imbalances, many patients continue to experience emotional distress. This study investigates the relationship between physical activity and perceived stress among Indian thyroid patients, aiming to explore the potential of exercise as a…

A 14-years-old man, contact lens carrier, initially presented to the emergency room with a corneal ulcer and recurrent inflammation in his left eye. He was initially treated with antibiotics, later adding topical and systemic antivirals when it was mistakenly considered, like herpetic keratitis. After fifteen days, he had intense photophobia and loss of vision. On ophthalmological examination superior perineuritis, annular infiltrate with epithelial defect, superficial punctate…

A 16-year-old man presented for consultation for second opinion for diagnosis of polyps in tarsal eyelid. Personal history of seasonal conjunctivitis and treatment with topical Tobramycin and Dexamethasone. Visual acuity is 20/20 in both eyes. On ophthalmologic examination, enormous papillae are observed in lower and upper tarsus (arrows) and conjunctival hyperemia (Figure 1). Rest of anterior segment and fundus examination are normal. Patient was diagnosed with vernal conjunctivitis,…