Introduction: The use of sedatives in frail older adults represents a significant challenge in clinical and nursing practice due to age-related pharmacokinetic and pharmacodynamic changes that increase susceptibility to adverse drug reactions. Physiological alterations such as reduced hepatic metabolism, decreased renal clearance, altered protein binding, and increased blood-brain barrier permeability enhance drug accumulation and central nervous system sensitivity.…

Introduction: Familial non-medullary thyroid carcinoma accounts for 3-7% of differentiated thyroid cancers. It is defined by the occurrence of papillary thyroid carcinoma in at least two first degree relatives in the absence of a known hereditary syndrome.

Case Presentation: We report the case of a 56-year-old mother and her 35-year-old daughter, both diagnosed with papillary thyroid carcinoma discovered in EU-TIRADS V classified nodules.…

The interaction between the central nervous system and respiratory musculature is pivotal in managing critically ill patients. This review examines the functional anatomy of primary and accessory respiratory muscles and evaluates the role of Neurophysiological Respiratory Facilitation (NPF). We discuss how external tactile and proprioceptive stimuli trigger reflex respiratory movement sequences, potentially through the activation of "Central Pattern Generators" (CPGs) and medullary…

Hydrogels represent a class of highly versatile, three-dimensional polymer networks renowned for their exceptional water absorption capacity, biocompatibility, and tunable physicochemical properties. This review comprehensively examines the diverse landscape of hydrogels, delineating the fundamental characteristics and applications of synthetic, natural, and advanced hybrid systems. It highlights the superior mechanical strength of synthetic hydrogels and the enhanced biocompatibility of…

Background: Severe thrombocytopenia in the postpartum period is a life-threatening condition requiring urgent differentiation between thrombotic thrombocytopenic purpura (TTP), disseminated intravascular coagulation (DIC), and HELLP syndrome. Early recognition significantly impacts survival.

Case Presentation: A 20-year-old previously healthy primiparous woman presented 7 days after spontaneous vaginal delivery with dyspnea, fatigue, abdominal…

Background: Preeclampsia is a major contributor to maternal and perinatal morbidity and mortality. While known risk factors include chronic hypertension, diabetes, and autoimmune disease, emerging evidence suggests a potential association between Chlamydia trachomatis infection and hypertensive disorders of pregnancy.

Objective: To evaluate whether Chlamydia trachomatis infection is associated with an increased risk of…

Systemic lupus erythematosus is an autoimmune disease resulting from a multifactorial disturbance of the immune system and responsible for systemic disorders (respiratory, cardiac, cutaneous, renal, hematological, etc.).

Pleural involvement in systemic lupus erythematosus is frequent. It represents a poor prognostic factor in the evolution of this pathology and has been part of its diagnostic criteria since the 1971 primary classification of systemic lupus erythematosus…

COVID-19 and its impact on dermatological health was reviewed from theoretical and statistical frameworks in the present study. A cross-sectional and retrospective work was documented with a selection of sources indexed to Scopus, considering the period from 2019 to 2021, as well as the search by keywords. Approaches were discussed in order to outline a comprehensive model that considered the differences between the parties involved, as well as their relationships in a risk context. The…

Crime scene management forms the cornerstone of forensic investigation, directly influencing the integrity, admissibility, and probative value of physical evidence. Improper scene handling can irreversibly compromise investigative outcomes. This narrative review discusses the theoretical foundations, procedural frameworks, and practical dimensions of crime scene management, integrating established forensic principles with field observations from operational experience at a regional forensic…

Objectives: To systematically review randomized controlled trials that have evaluated elasticated thrombo-embolic graduated compression stockings as prophylaxis of deep venous thrombosis in various health situations.

Design: Searches were carried out in the Cochrane Central Register of Controlled Trials, Medline, EMBASE and CINAHL and the results hand searched for trials registered up to March 2021.

Participants: A…